Neurosteroids in Cognitive Disorder - From Well-Known Pharmacological Aspects to a Source of Controversy
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Aug 03, 2020
About this article
Published Online: Aug 03, 2020
Page range: 23 - 27
Received: Jan 25, 2019
Accepted: Feb 24, 2020
DOI: https://doi.org/10.2478/amtsb-2020-0007
Keywords
© 2020 Mădălina-Georgiana Bătrînu et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
The nervous system is not just a target organ for synthetic steroids. It is also controlled in a certain manner by steroids synthesized de novo in the brain, at the level of both neurones and glial cells. The impressive recent number of literature studies, clearly demonstrates the presence of enzymes necessary for syntheses of central neurosteroids and also the mechanism by which they act. Neurosteroids play a considerable part as an endogenous modulator of brain function and behaviour processes, and the decrease of their concentration can be associated with the pathophysiology of different neurological diseases accompanied by cognitive disorders such as depression, anxiety, schizophrenia, Alzheimer disease.