Different damaging effects of volatile anaesthetics alone or in combination with 1 and 2 Gy gamma-irradiation in vivo on mouse liver DNA: a preliminary study

1. International Agency for Research on Cancer (IARC). Monographs on the Evaluation of Carcinogenic Risks to Humans. Radiation. Volume 100D, 2012 [displayed 14 August 2022]. Available at https://publications.iarc.fr/Book-And-Report-Series/Iarc-Monographs-On-The-Identification-Of-Carcinogenic-Hazards-To-Humans/Radiation-2012 International Agency for Research on Cancer (IARC) . Monographs on the Evaluation of Carcinogenic Risks to Humans . Radiation . Volume 100D , 2012 [displayed 14 August 2022]. Available at https://publications.iarc.fr/Book-And-Report-Series/Iarc-Monographs-On-The-Identification-Of-Carcinogenic-Hazards-To-Humans/Radiation-2012 Search in Google Scholar

2. The Royal College of Radiologists. Radiology Dose Fractionation. Third edition. London: RCR; 2019 [displayed 14 August 2022]. Available at https://www.rcr.ac.uk/system/files/publication/field_publication_files/brfo193_radiotherapy_dose_fractionation_third-edition.pdf The Royal College of Radiologists . Radiology Dose Fractionation. Third edition . London : RCR ; 2019 [displayed 14 August 2022]. Available at https://www.rcr.ac.uk/system/files/publication/field_publication_files/brfo193_radiotherapy_dose_fractionation_third-edition.pdf Search in Google Scholar

3. Rafat M, Ali R, Graves EE. Imaging radiation response in tumor and normal tissue. Am J Nucl Med Mol Imaging 2015;5:317–32. PMID: 26269771 Rafat M Ali R Graves EE . Imaging radiation response in tumor and normal tissue . Am J Nucl Med Mol Imaging 2015 ; 5 : 317 – 32 . PMID: 26269771 Search in Google Scholar

4. Arunkumar R, Rebello E, Owusu-Agyemang P. Anesthetic techniques for unique cancer surgery procedures. Best Pract Res Clin Anaesthesiol 2013;27:513–26. doi: 10.1016/j.bpa.2013.09.002 Arunkumar R Rebello E Owusu-Agyemang P . Anesthetic techniques for unique cancer surgery procedures . Best Pract Res Clin Anaesthesiol 2013 ; 27 : 513 – 26 . doi: 10.1016/j.bpa.2013.09.002 Open DOISearch in Google Scholar

5. Ntoukas SM, Ritchie T, Awrey S, Hodgson DC, Laperriere N, Yee R, Ramaswamy V, Millar BA, Becker N, Tsang DS. Minimizing general anesthetic use in pediatric radiation therapy. Pract Radiat Oncol 2020;10:e159–65. doi: 10.1016/j.prro.2019.12.001 Ntoukas SM Ritchie T Awrey S Hodgson DC Laperriere N Yee R Ramaswamy V Millar BA Becker N Tsang DS . Minimizing general anesthetic use in pediatric radiation therapy . Pract Radiat Oncol 2020 ; 10 : e159 – 65 . doi: 10.1016/j.prro.2019.12.001 Open DOISearch in Google Scholar

6. Campagna JA, Miller KW, Forman SA. Mechanisms of actions of inhaled anesthetics. N Engl J Med 2003;348:2110–24. doi: 10.1056/NEJMra021261 Campagna JA Miller KW Forman SA . Mechanisms of actions of inhaled anesthetics . N Engl J Med 2003 ; 348 : 2110 – 24 . doi: 10.1056/NEJMra021261 Open DOISearch in Google Scholar

7. Brozovic G, Orsolic N, Rozgaj R, Kasuba V, Knezevic F, Horvat Knezevic A, Benkovic V, Lisicic D, Borojevic N, Dikic D. DNA damage and repair after exposure to sevoflurane in vivo, evaluated in Swiss albino mice by the alkaline comet assay and micronucleus test. J Appl Genet 2010;51:79–86. doi: 10.1007/BF03195714 Brozovic G Orsolic N Rozgaj R Kasuba V Knezevic F Horvat Knezevic A Benkovic V Lisicic D Borojevic N Dikic D . DNA damage and repair after exposure to sevoflurane in vivo, evaluated in Swiss albino mice by the alkaline comet assay and micronucleus test . J Appl Genet 2010 ; 51 : 79 – 86 . doi: 10.1007/BF03195714 Open DOISearch in Google Scholar

8. Chiao S, Zuo Z. A double-edged sword: volatile anesthetic effects on the neonatal brain. Brain Sci 2014;4:273–94. doi: 10.3390/brainsci4020273 Chiao S Zuo Z . A double-edged sword: volatile anesthetic effects on the neonatal brain . Brain Sci 2014 ; 4 : 273 – 94 . doi: 10.3390/brainsci4020273 Open DOISearch in Google Scholar

9. Yılmaz S, Çalbayram NÇ. Exposure to anesthetic gases among operating room personnel and risk of genotoxicity: A systematic review of the human biomonitoring studies. J Clin Anesth 2016;35:326–31. doi: 10.1016/j.jclinane.2016.08.029 Yılmaz S Çalbayram NÇ . Exposure to anesthetic gases among operating room personnel and risk of genotoxicity: A systematic review of the human biomonitoring studies . J Clin Anesth 2016 ; 35 : 326 – 31 . doi: 10.1016/j.jclinane.2016.08.029 Open DOISearch in Google Scholar

10. Brozovic G, Orsolic N, Knezevic F, Horvat Knezevic A, Benkovic V, Sakic K, Borojevic N, Dikic D. The in vivo genotoxicity of cisplatin, isoflurane and halothane evaluated by alkaline comet assay in Swiss albino mice. J Appl Genet 2011;52:355–61. doi: 10.1007/s13353-011-0046-0 Brozovic G Orsolic N Knezevic F Horvat Knezevic A Benkovic V Sakic K Borojevic N Dikic D . The in vivo genotoxicity of cisplatin, isoflurane and halothane evaluated by alkaline comet assay in Swiss albino mice . J Appl Genet 2011 ; 52 : 355 – 61 . doi: 10.1007/s13353-011-0046-0 Open DOISearch in Google Scholar

11. Brozović G, Oršolić N, Rozgaj R, Knežević F, Horvat Knežević A, Maričić M, Krsnik D, Benković V. Sevoflurane and isoflurane genotoxicity in kidney cells of mice. Arh Hig Rada Toksikol 2017;68:228–35. doi: 10.1515/aiht-2017-68-2941 Brozović G Oršolić N Rozgaj R Knežević F Horvat Knežević A Maričić M Krsnik D Benković V . Sevoflurane and isoflurane genotoxicity in kidney cells of mice . Arh Hig Rada Toksikol 2017 ; 68 : 228 – 35 . doi: 10.1515/aiht-2017-68-2941 Open DOISearch in Google Scholar

12. Milić M, Rozgaj R, Kašuba V, Jazbec AM, Hrelia P, Angelini S. The influence of individual genome sensitivity in DNA damage repair assessment in chronic professional exposure to low doses of ionizing radiation. In: Chen CC, editor. Selected Topics in DNA Repair. IntechOpen, Croatia 2011 [displayed 14 July 2022]. Available at https://https://www.intechopen.com/chapters/22725. doi: 10.5772/20814 Milić M Rozgaj R Kašuba V Jazbec AM Hrelia P Angelini S . The influence of individual genome sensitivity in DNA damage repair assessment in chronic professional exposure to low doses of ionizing radiation . In: Chen CC , editor. Selected Topics in DNA Repair . IntechOpen , Croatia 2011 [displayed 14 July 2022]. Available at https://https://www.intechopen.com/chapters/22725. doi: 10.5772/20814 Open DOISearch in Google Scholar

13. Alcaraz M, Acevedo C, Castillo J, Benavente-Garcia O, Armero D, Vicente V, Canteras M. Liposoluble antioxidants provide an effective radioprotective barrier. Br J Radiol 2009;82:605–9. doi: 10.1259/bjr/30930369 Alcaraz M Acevedo C Castillo J Benavente-Garcia O Armero D Vicente V Canteras M . Liposoluble antioxidants provide an effective radioprotective barrier . Br J Radiol 2009 ; 82 : 605 – 9 . doi: 10.1259/bjr/30930369 Open DOISearch in Google Scholar

14. Benković V, Borojević N, Šikić D, Horvat Knežević A, Milić M. DNA damage assessment in peripheral blood of Swiss albino mice after combined exposure to volatile anesthetics and 1 or 2 Gy radiotherapy in vivo. Int J Radiat Biol 2021;97:1425–35. doi: 10.1080/09553002.2021.1962565 Benković V Borojević N Šikić D Horvat Knežević A Milić M . DNA damage assessment in peripheral blood of Swiss albino mice after combined exposure to volatile anesthetics and 1 or 2 Gy radiotherapy in vivo . Int J Radiat Biol 2021 ; 97 : 1425 – 35 . doi: 10.1080/09553002.2021.1962565 Open DOISearch in Google Scholar

15. Zakon o zaštiti životinja [Animal protection act, in Croatian]. Narodne novine 102/2017. Zakon o zaštiti životinja [Animal protection act, in Croatian] . Narodne novine 102 / 2017 . Search in Google Scholar

16. Pravilnik o zaštiti životinja koje se koriste u znanstvene svrhe [Act on protection of animals used for scientific purposes, in Croatian]. Narodne novine 55/2013. Pravilnik o zaštiti životinja koje se koriste u znanstvene svrhe [Act on protection of animals used for scientific purposes, in Croatian] . Narodne novine 55 / 2013 . Search in Google Scholar

17. Pravilnik o izmjenama pravilnika o zaštiti životinja koje se koriste u znanstvene svrhe [Act on amendments to the Act on protection of animals used for scientific purposes, in Croatian]. Narodne novine 39/2017. Pravilnik o izmjenama pravilnika o zaštiti životinja koje se koriste u znanstvene svrhe [Act on amendments to the Act on protection of animals used for scientific purposes, in Croatian] . Narodne novine 39 / 2017 . Search in Google Scholar

18. Directive 2010/63/EU of the European Parliament and of the Council of 22 September 2010 on the protection of animals used for scientific purposes [displayed 7 March 2023]. Available at https://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:2010:276:0033:0079:En:PDF Directive 2010/63/EU of the European Parliament and of the Council of 22 September 2010 on the protection of animals used for scientific purposes [displayed 7 March 2023]. Available at https://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:2010:276:0033:0079:En:PDF Search in Google Scholar

19. Narendran N, Luzhna L, Kovalchuk O. Sex difference of radiation response in occupational and accidental exposure. Front Genet 2019;10:260. doi: 10.3389/fgene.2019.00260 Narendran N Luzhna L Kovalchuk O . Sex difference of radiation response in occupational and accidental exposure . Front Genet 2019 ; 10 : 260 . doi: 10.3389/fgene.2019.00260 Open DOISearch in Google Scholar

20. Collins A, Milic M, Bonassi S, Dusinska M. The comet assay in human biomonitoring: Technical and epidemiological perspectives. Mutat Res Genet Toxicol Environ Mutagen 2019;843:1–2. doi: 10.1016/j.mrgentox.2019.06.002 Collins A Milic M Bonassi S Dusinska M . The comet assay in human biomonitoring: Technical and epidemiological perspectives . Mutat Res Genet Toxicol Environ Mutagen 2019 ; 843 : 1 – 2 . doi: 10.1016/j.mrgentox.2019.06.002 Open DOISearch in Google Scholar

21. Xiao C, He N, Liu Y, Wang Y, Liu Q. Research progress on biodosimeters of ionizing radiation damage. Rad Med Protec 2020;1:127–32. doi: 10.1016/j.radmp.2020.06.002 Xiao C He N Liu Y Wang Y Liu Q . Research progress on biodosimeters of ionizing radiation damage . Rad Med Protec 2020 ; 1 : 127 – 32 . doi: 10.1016/j.radmp.2020.06.002 Open DOISearch in Google Scholar

22. Milić M, Ceppi M, Bruzzone M, Azqueta A, Brunborg G, Godschalk R, Koppen G, Langie S, Møller P, Teixeira JP, Alija A, Anderson D, Andrade V, Andreoli C, Asllani F, Bangkoglu EE, Barančoková M, Basaran N, Boutet-Robinet E, Buschini A, Cavallo D, Costa Pereira C, Costa C, Costa S, Da Silva J, Del Bo’ C, Dimitrijević Srećković V, Djelić N, Dobrzyńska M, Duračková Z, Dvořáková M, Gajski G, Galati S, García Lima O, Giovannelli L, Goroshinskaya IA, Grindel A, Gutzkow KB, Hernández A, Hernández C, Holven KB, Ibero-Baraibar I, Ot-testad I, Kadioglu E, Kažimirová A, Kuznetsova E, Ladeira C, Laffon B, Lamonaca P, Lebailly P, Louro H, Mandina Cardoso T, Marcon F, Marcos R, Moretti M, Moretti S, Najafzadeh M, Nemeth Z, Neri M, Novotna B, Orlow I, Paduchova Z, Pastor S, Perdry H, Spremo-Potparević B, Ramadhani D, Riso P, Rohr P, Rojas E, Rossner P, Safar A, Sardas S, Silva MJ, Sirota N, Smolkova B, Staruchova M, Stetina R, Stopper H, Surikova EI, Ulven SM, Ursini CL, Valdiglesias V, Valverde M, Vodicka P, Volkovova K, Wagner KH, Živković L, Dušinská M, Collins AR, Bonassi S. The hCOMET project: International database comparison of results with the comet assay in human biomonitoring. Baseline frequency of DNA damage and effect of main confounders. Mutat Res Rev Mutat Res 2021;787:108371. doi: 10.1016/j.mrrev.2021.108371 Milić M Ceppi M Bruzzone M Azqueta A Brunborg G Godschalk R Koppen G Langie S Møller P Teixeira JP Alija A Anderson D Andrade V Andreoli C Asllani F Bangkoglu EE Barančoková M Basaran N Boutet-Robinet E Buschini A Cavallo D Costa Pereira C Costa C Costa S Da Silva J Del Bo’ C Dimitrijević Srećković V Djelić N Dobrzyńska M Duračková Z Dvořáková M Gajski G Galati S García Lima O Giovannelli L Goroshinskaya IA Grindel A Gutzkow KB Hernández A Hernández C Holven KB Ibero-Baraibar I Ot-testad I Kadioglu E Kažimirová A Kuznetsova E Ladeira C Laffon B Lamonaca P Lebailly P Louro H Mandina Cardoso T Marcon F Marcos R Moretti M Moretti S Najafzadeh M Nemeth Z Neri M Novotna B Orlow I Paduchova Z Pastor S Perdry H Spremo-Potparević B Ramadhani D Riso P Rohr P Rojas E Rossner P Safar A Sardas S Silva MJ Sirota N Smolkova B Staruchova M Stetina R Stopper H Surikova EI Ulven SM Ursini CL Valdiglesias V Valverde M Vodicka P Volkovova K Wagner KH Živković L Dušinská M Collins AR Bonassi S . The hCOMET project: International database comparison of results with the comet assay in human biomonitoring. Baseline frequency of DNA damage and effect of main confounders . Mutat Res Rev Mutat Res 2021 ; 787 : 108371 . doi: 10.1016/j.mrrev.2021.108371 Open DOISearch in Google Scholar

23. OECD. Test No. 489: In Vivo Mammalian Alkaline Comet Assay, OECD Guidelines for the Testing of Chemicals, Section 4. Paris: OECD; 2016 [displayed 14 July 2022]. Available at https://doi.org/10.1787/9789264264885-en OECD . Test No. 489: In Vivo Mammalian Alkaline Comet Assay, OECD Guidelines for the Testing of Chemicals, Section 4 . Paris : OECD ; 2016 [displayed 14 July 2022]. Available at https://doi.org/10.1787/9789264264885-en Search in Google Scholar

24. Møller P, Azqueta A, Boutet-Robinet E, Koppen G, Bonassi S, Milić M, Gajski G, Costa S, Teixeira JP, Costa Pereira C, Dusinska M, Godschalk R, Brunborg G, Gutzkow KB, Giovannelli L, Cooke MS, Richling E, Laffon B, Valdiglesias V, Basaran N, Del Bo’ C, Zegura B, Novak M, Stopper H, Vodicka P, Vodenkova S, de Andrade VM, Sramkova M, Gabelova A, Collins A, Langie SAS. Minimum Information for Reporting on the Comet Assay (MIRCA): recommendations for describing comet assay procedures and results. Nat Protoc 2020;15:3817–26. doi: 10.1038/s41596-020-0398-1 Møller P Azqueta A Boutet-Robinet E Koppen G Bonassi S Milić M Gajski G Costa S Teixeira JP Costa Pereira C Dusinska M Godschalk R Brunborg G Gutzkow KB Giovannelli L Cooke MS Richling E Laffon B Valdiglesias V Basaran N Del Bo’ C Zegura B Novak M Stopper H Vodicka P Vodenkova S de Andrade VM Sramkova M Gabelova A Collins A Langie SAS . Minimum Information for Reporting on the Comet Assay (MIRCA): recommendations for describing comet assay procedures and results . Nat Protoc 2020 ; 15 : 3817 – 26 . doi: 10.1038/s41596-020-0398-1 Open DOISearch in Google Scholar

25. Collins AR. The comet assay for DNA damage and repair: principles, applications, and limitations. Mol Biotechnol 2004;26:249–61. doi: 10.1385/MB:26:3:249 Collins AR . The comet assay for DNA damage and repair: principles, applications, and limitations . Mol Biotechnol 2004 ; 26 : 249 – 61 . doi: 10.1385/MB:26:3:249 Open DOISearch in Google Scholar

26. Singh NP, McCoy MT, Tice RR, Schneider EL. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 1988;175:184–91. doi: 10.1016/0014-4827(88)90265-0 Singh NP McCoy MT Tice RR Schneider EL . A simple technique for quantitation of low levels of DNA damage in individual cells . Exp Cell Res 1988 ; 175 : 184 – 91 . doi: 10.1016/0014-4827(88)90265-0 Open DOISearch in Google Scholar

27. Nair GG, Nair CKK. Protection of cellular DNA and membrane from γ-radiation-induced damages and enhancement in DNA repair by sesamol. Cancer Biother Radiopharm 2010;25:629–35. doi: 10.1089/cbr.2010.0803 Nair GG Nair CKK . Protection of cellular DNA and membrane from γ-radiation-induced damages and enhancement in DNA repair by sesamol . Cancer Biother Radiopharm 2010 ; 25 : 629 – 35 . doi: 10.1089/cbr.2010.0803 Open DOISearch in Google Scholar

28. Chatterjee N, Walker GC. Mechanisms of DNA damage, repair, and mutagenesis. Environ Mol Mutagen 2017;58:235–63. doi: 10.1002/em.22087 Chatterjee N Walker GC . Mechanisms of DNA damage, repair, and mutagenesis . Environ Mol Mutagen 2017 ; 58 : 235 – 63 . doi: 10.1002/em.22087 Open DOISearch in Google Scholar

29. Van Allen NR, Krafft PR, Leitzke AS, Applegate RL 2^nd, Tang J, Zhang JH. The role of volatile anesthetics in cardioprotection: a systematic review. Med Gas Res 2012:2(1):22. doi: 10.1186/2045-9912-2-22 Van Allen NR Krafft PR Leitzke AS Applegate RL 2nd Tang J Zhang JH . The role of volatile anesthetics in cardioprotection: a systematic review . Med Gas Res 2012 : 2 ( 1 ): 22 . doi: 10.1186/2045-9912-2-22 Open DOISearch in Google Scholar

30. Kharasch ED, Frink Jr EJ, Zager R, Bowdle TA, Artru A, Nogami WM. Assessment of low-flow sevoflurane and isoflurane effects on renal function using sensitive markers of tubular toxicity. Anesthesiology 1997;86:1238–53. doi: 10.1097/00000542-199706000-00004 Kharasch ED Frink EJ Jr Zager R Bowdle TA Artru A Nogami WM . Assessment of low-flow sevoflurane and isoflurane effects on renal function using sensitive markers of tubular toxicity . Anesthesiology 1997 ; 86 : 1238 – 53 . doi: 10.1097/00000542-199706000-00004 Open DOISearch in Google Scholar

31. Braz MG, Mazzoti MÁ, Giacobino J, Braz LG, de Assis Golim M, Ferrasi AC, de Carvalho LR, Braz JR, Salvadori DM. Genotoxicity, cytotoxicity and gene expression in patients undergoing elective surgery under isoflurane anesthesia. Mutagenesis 2011;26:415–20. doi: 10.1093/mutage/geq109 Braz MG Mazzoti MÁ Giacobino J Braz LG de Assis Golim M Ferrasi AC de Carvalho LR Braz JR Salvadori DM . Genotoxicity, cytotoxicity and gene expression in patients undergoing elective surgery under isoflurane anesthesia . Mutagenesis 2011 ; 26 : 415 – 20 . doi: 10.1093/mutage/geq109 Open DOISearch in Google Scholar

32. Braz MG, Braz JG, Braz JR, Pierine DT, Correa CR, Ferreira AL, Carvalho LR, Yeum KJ, Salvadori DM. Comparison of oxidative stress in ASA physical status I patients scheduled for minimally invasive surgery under balanced or intravenous anesthesia. Minerva Anestesiol 2013;79:1030–8. PMID: 23598734 Braz MG Braz JG Braz JR Pierine DT Correa CR Ferreira AL Carvalho LR Yeum KJ Salvadori DM . Comparison of oxidative stress in ASA physical status I patients scheduled for minimally invasive surgery under balanced or intravenous anesthesia . Minerva Anestesiol 2013 ; 79 : 1030 – 8 . PMID: 23598734 Search in Google Scholar

33. Rocha TL, Dias-Junior CA, Possomato-Vieira JS, Gonçalves-Rizzi VH, Nogueira FR, de Souza KM, Braz LG, Braz MG. Sevoflurane induces DNA damage whereas isoflurane leads to higher antioxidative status in anesthetized rats. Biomed Res Int 2015;2015:264971. doi: 10.1155/2015/264971 Rocha TL Dias-Junior CA Possomato-Vieira JS Gonçalves-Rizzi VH Nogueira FR de Souza KM Braz LG Braz MG . Sevoflurane induces DNA damage whereas isoflurane leads to higher antioxidative status in anesthetized rats . Biomed Res Int 2015 ; 2015 : 264971 . doi: 10.1155/2015/264971 Open DOISearch in Google Scholar

34. Hoetzel A, Schmidt R. Regulatory role of anesthetics on heme oxygenase-1. Curr Drug Targets 2010;11:1495–503. doi: 10.2174/1389450111009011495 Hoetzel A Schmidt R . Regulatory role of anesthetics on heme oxygenase-1 . Curr Drug Targets 2010 ; 11 : 1495 – 503 . doi: 10.2174/1389450111009011495 Open DOISearch in Google Scholar

35. Karabiyik L, Sardaş S, Polat U, KocabaS NA, Karakaya AE. Comparison of genotoxicity of sevoflurane and isoflurane in human lymphocytes studied in vivo using the comet assay. Mutat Res 2001;492:99–107. doi: 10.1016/s1383-5718(01)00159-0 Karabiyik L Sardaş S Polat U KocabaS NA Karakaya AE . Comparison of genotoxicity of sevoflurane and isoflurane in human lymphocytes studied in vivo using the comet assay . Mutat Res 2001 ; 492 : 99 – 107 . doi: 10.1016/s1383-5718(01)00159-0 Open DOISearch in Google Scholar

36. Benković V, Oršolić N, Knežević AH, Borojević N, Brozović G, Milić M. Kidney cell DNA damage caused by combined exposure to volatile anesthetics and 1 Gy or 2 Gy radiotherapy dose in vivo. Arh Hig Rada Toksikol 2022;73:62–70. doi: 10.2478/aiht-2022-73-3600 Benković V Oršolić N Knežević AH Borojević N Brozović G Milić M . Kidney cell DNA damage caused by combined exposure to volatile anesthetics and 1 Gy or 2 Gy radiotherapy dose in vivo . Arh Hig Rada Toksikol 2022 ; 73 : 62 – 70 . doi: 10.2478/aiht-2022-73-3600 Open DOISearch in Google Scholar

37. Benković V, Milić M, Oršolić N, Horvat Knežević A, Brozović G, Borojević N. Brain DNA damaging effects of volatile anesthetics, 1 and 2 Gy gamma-irradiation in vivo: Preliminary results. Toxicol Ind Health 2023;39:67–80. doi: 10.1177/0748233722114559 Benković V Milić M Oršolić N Horvat Knežević A Brozović G Borojević N . Brain DNA damaging effects of volatile anesthetics, 1 and 2 Gy gamma-irradiation in vivo: Preliminary results . Toxicol Ind Health 2023 ; 39 : 67 – 80 . doi: 10.1177/0748233722114559 Open DOISearch in Google Scholar

38. Brozovic G, Orsolic N, Knezevic F, Horvat Knezevic A, Benkovic V, Vrdoljak DV, Saric A. Evaluation of DNA damage in vivo induced by combined application of cisplatin and sevoflurane. Eur J Anaesthesiol 2008;25:642–7. doi: 10.1017/S0265021508004171 Brozovic G Orsolic N Knezevic F Horvat Knezevic A Benkovic V Vrdoljak DV Saric A . Evaluation of DNA damage in vivo induced by combined application of cisplatin and sevoflurane . Eur J Anaesthesiol 2008 ; 25 : 642 – 7 . doi: 10.1017/S0265021508004171 Open DOISearch in Google Scholar

39. Davis PJ, Bosenberg A, Davidson A, Jimenez N, Kharasch E, Lynn AM, Tofovic SP, Woelfel S. Pharmacology of pediatric anesthesia. In: Davis PJ, Cladis FP, Motoyama EK, editors. Smith’s Anesthesia for Infants and Children. 8^th ed. Elsevier, Mosby 2011. p. 179–61. Davis PJ Bosenberg A Davidson A Jimenez N Kharasch E Lynn AM Tofovic SP Woelfel S . Pharmacology of pediatric anesthesia . In: Davis PJ Cladis FP Motoyama EK , editors. Smith’s Anesthesia for Infants and Children . 8^th ed. Elsevier , Mosby 2011 . p. 179 – 61 . Search in Google Scholar

40. Edgington TL, Muco E, Maani CV. Sevoflurane. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; Updated 2022 Jun 19 [displayed 14 July 2022]. Available at https://www.ncbi.nlm.nih.gov/books/NBK534781 Edgington TL Muco E Maani CV . Sevoflurane . In: StatPearls [Internet] . Treasure Island (FL) : StatPearls Publishing ; Updated 2022 Jun 19 [displayed 14 July 2022]. Available at https://www.ncbi.nlm.nih.gov/books/NBK534781 Search in Google Scholar

41. Martin Jr. JL, Njoku DB. Metabolism and toxicity of modern inhaled anesthetics. In: Miller´s anesthesia. 6^th ed. Philadelphia: Elsevier; 2005. p. 231–72. Martin JL Jr. Njoku DB . Metabolism and toxicity of modern inhaled anesthetics . In: Miller´s anesthesia . 6th ed. Philadelphia : Elsevier ; 2005 . p. 231 – 72 . Search in Google Scholar

42. Tanko B, Molnar L, Fuksedi B, Molnar C. Occupational hazards of halogenated volatile anesthetics and their prevention: review of the literature. J Anesth Clin Res 2014;5:7. doi: 10.4172/2155-6148.1000426 Tanko B Molnar L Fuksedi B Molnar C . Occupational hazards of halogenated volatile anesthetics and their prevention: review of the literature . J Anesth Clin Res 2014 ; 5 : 7 . doi: 10.4172/2155-6148.1000426 Open DOISearch in Google Scholar

43. Gyorfi MJ, Kim PY. Halothane Toxicity. Treasure Island (FL): StatPearls Publishing; 2022 [displayed 14 July 2022]. Available at https://www.ncbi.nlm.nih.gov/books/NBK545281/ Gyorfi MJ Kim PY . Halothane Toxicity . Treasure Island (FL) : StatPearls Publishing ; 2022 [displayed 14 July 2022]. Available at https://www.ncbi.nlm.nih.gov/books/NBK545281/ Search in Google Scholar

44. Alleva R, Tomasetti M, Solenghi MD, Stagni F, Gamberini F, Bassi A, Fornasari PM, Fanelli G, Borghi B. Lymphocyte DNA damage precedes DNA repair or cell death after orthopedic surgery under general anaesthesia. Mutagenesis 2003;18:423–8. doi: 10.1093/mutage/geg013 Alleva R Tomasetti M Solenghi MD Stagni F Gamberini F Bassi A Fornasari PM Fanelli G Borghi B . Lymphocyte DNA damage precedes DNA repair or cell death after orthopedic surgery under general anaesthesia . Mutagenesis 2003 ; 18 : 423 – 8 . doi: 10.1093/mutage/geg013 Open DOISearch in Google Scholar

45. Kadioglu E, Sardas S, Erturk S, Ozatamer O, Karakaya AE. Determination of DNA damage by alkaline halo and comet assay in patients under sevoflurane anesthesia. Toxicol Ind Health 2009;25:205–12. doi: 10.1177/0748233709106445 Kadioglu E Sardas S Erturk S Ozatamer O Karakaya AE . Determination of DNA damage by alkaline halo and comet assay in patients under sevoflurane anesthesia . Toxicol Ind Health 2009 ; 25 : 205 – 12 . doi: 10.1177/0748233709106445 Open DOISearch in Google Scholar

46. Szyfter K, Szulc R, Mikstacki A, Stachecki I, Rydzanicz M, Jałoszyński P. Genotoxicity of inhalation anaesthetics: DNA lesions generated by sevoflurane in vitro and in vivo. J Appl Genet 2004;45:369–74. PMID: 15306730 Szyfter K Szulc R Mikstacki A Stachecki I Rydzanicz M Jałoszyński P . Genotoxicity of inhalation anaesthetics: DNA lesions generated by sevoflurane in vitro and in vivo . J Appl Genet 2004 ; 45 : 369 – 74 . PMID: 15306730 Search in Google Scholar

47. Wiesner G, Schiewe-Langgartner F, Lindner R, Gruber M. Increased formation of sister chromatid exchanges, but not of micronuclei, in anaesthetists exposed to low levels of sevoflurane. Anaesthesia 2008;63:861–4. doi: 10.1111/j.1365-2044.2008.05498.x Wiesner G Schiewe-Langgartner F Lindner R Gruber M . Increased formation of sister chromatid exchanges, but not of micronuclei, in anaesthetists exposed to low levels of sevoflurane . Anaesthesia 2008 ; 63 : 861 – 4 . doi: 10.1111/j.1365-2044.2008.05498.x Open DOISearch in Google Scholar

48. Braz MG, Braz LG, Barbosa BS, Giacobino J, Orosz JE, Salvadori DM, Braz JR. DNA damage in patients who underwent minimally invasive surgery under inhalation or intravenous anesthesia. Mutat Res 2011;726:251–4. doi: 10.1016/j.mrgentox.2011.09.007 Braz MG Braz LG Barbosa BS Giacobino J Orosz JE Salvadori DM Braz JR . DNA damage in patients who underwent minimally invasive surgery under inhalation or intravenous anesthesia . Mutat Res 2011 ; 726 : 251 – 4 . doi: 10.1016/j.mrgentox.2011.09.007 Open DOISearch in Google Scholar

49. Pokhrel LR, Grady KD. Risk assessment of occupational exposure to anesthesia Isoflurane in the hospital and veterinary settings. Sci Total Environ 2021:783:146894. doi: 10.1016/j.scitotenv.2021.146894 Pokhrel LR Grady KD . Risk assessment of occupational exposure to anesthesia Isoflurane in the hospital and veterinary settings . Sci Total Environ 2021 : 783 : 146894 . doi: 10.1016/j.scitotenv.2021.146894 Open DOISearch in Google Scholar