Olanzapine poisoning in patients treated at the National Poison Control Centre in Belgrade, Serbia in 2017 and 2018: a brief review of serum concentrations and clinical symptoms
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Ritter J, Flower R, Henderson G, Loke YK, MacEwan D, Rang H. Rang & Dale’s Pharmacology. 9th ed. Amsterdam: Elsevier Science; 2019.RitterJFlowerRHendersonGLokeYKMacEwanDRangHAmsterdamElsevier Science2019Search in Google Scholar
Fulton B, Goa KL. Olanzapine. A review of its pharmacological properties and therapeutic efficacy in the management of schizophrenia and related psychoses. Drugs 1997;53:281–98. doi: 10.2165/00003495-199753020-00007FultonBGoaKLOlanzapine. A review of its pharmacological properties and therapeutic efficacy in the management of schizophrenia and related psychoses1997532819810.2165/00003495-199753020-000079028746Open DOISearch in Google Scholar
Moffat AC, Osselton D, Widdop B, Watts J. Clarke’s Analysis of Drugs and Poisons. 4th ed. London: Pharmaceutical Press; 2011.MoffatACOsseltonDWiddopBWattsJLondonPharmaceutical Press;2011Search in Google Scholar
Robertson M, McMullin M. Olanzapine concentrations in clinical serum and postmortem blood specimens-when does therapeutic become toxic? J Forensic Sci 2000;45:418–21. doi: 10.1520/JFS14697JRobertsonMMcMullinMOlanzapine concentrations in clinical serum and postmortem blood specimens-when does therapeutic become toxic?2000454182110.1520/JFS14697JOpen DOISearch in Google Scholar
Palenzona S, Meier PJ, Kupferschmidt H, Rauber-Luethy C. The clinical picture of olanzapine poisoning with special reference to fluctuating mental status. J Toxicol Clin Toxicol 2004;42:27–32. doi: 10.1081/clt-120028741PalenzonaSMeierPJKupferschmidtHRauber-LuethyCThe clinical picture of olanzapine poisoning with special reference to fluctuating mental status200442273210.1081/clt-12002874115083933Open DOISearch in Google Scholar
Singh LK, Praharai SK, Sahu M. Nonfatal suicidal overdose of olanzapine in an adolescent. Curr Drug Saf 2012;7:328–9. doi: 10.2174/157488612804096605SinghLKPraharaiSKSahuMNonfatal suicidal overdose of olanzapine in an adolescent20127328910.2174/157488612804096605Open DOISearch in Google Scholar
Arora M, Praharai SK. Nonfatal suicidal olanzapine overdose: a case report. Clin Neuropharmacol 2006;29:190–1. doi: 10.1097/01.WNF.0000228175.90959.43AroraMPraharaiSKNonfatal suicidal olanzapine overdose: a case report200629190110.1097/01.WNF.0000228175.90959.4316855419Open DOISearch in Google Scholar
McAllister RK, Tutt CD, Colvin CS. Lipid 20 % emulsion ameliorates the symptoms of olanzapine toxicity in a 4-year-old. Am J Emerg Med 2012;30(6):1012.e1–2. doi: 10.1016/j.ajem.2011.03.025McAllisterRKTuttCDColvinCSLipid 20 % emulsion ameliorates the symptoms of olanzapine toxicity in a 4-year-old20123061012e1–210.1016/j.ajem.2011.03.02521641141Open DOISearch in Google Scholar
Boz Z, Hu M, Yu Y, Huang XF. N-acetylcysteine prevents olanzapine-induced oxidative stress in mHypoA-59 hypothalamic neurons. Sci Rep 2020;10:19185. doi: 10.1038/s41598-020-75356-3BozZHuMYuYHuangXFN-acetylcysteine prevents olanzapine-induced oxidative stress in mHypoA-59 hypothalamic neurons2020101918510.1038/s41598-020-75356-3764471533154380Open DOISearch in Google Scholar
Keyal N, Shrestha GS, Pradhan S, Maharjan R, Acharya PS, Marhatta MN. Olanzapine overdose presenting with acute muscle toxicity. Int J Crit Illn Ini Sci 2017;7:69–71. doi: 10.4103/2229-5151.201962KeyalNShresthaGSPradhanSMaharjanRAcharyaPSMarhattaMNOlanzapine overdose presenting with acute muscle toxicity20177697110.4103/2229-5151.201962536477128382261Open DOISearch in Google Scholar
Nelson L, Howland MA, Lewin N, Smith S, Goldfrank L, Hoffman R. Goldfrank’s Toxicologic Emergencies. 11th ed. New York: McGraw Hill Education; 2019.NelsonLHowlandMALewinNSmithSGoldfrankLHoffmanRNew YorkMcGraw Hill Education;2019Search in Google Scholar
Tse G, Warner M, Waring S. Prolonged toxicity after massive olanzapine overdose: two cases with confirmatory laboratory data. J Toxicol Sci 2008;33:363–5. doi: 10.2131/jts.33.363TseGWarnerMWaringSProlonged toxicity after massive olanzapine overdose: two cases with confirmatory laboratory data200833363510.2131/jts.33.36318670167Open DOISearch in Google Scholar
Morgan M, Hacket LP, Isbisiter GK. Olanzapine overdose: a series of analytically confirmed cases. Int Clin Psychopharmacol 2007;22:183–6. doi: 10.1097/YIC.0b013e32805aedf5MorganMHacketLPIsbisiterGKOlanzapine overdose: a series of analytically confirmed cases200722183610.1097/YIC.0b013e32805aedf517414746Open DOISearch in Google Scholar
Johal BK, Shelly MP. Olanzapine overdose. Anaesthesia 2000;55:929. doi: 10.1046/j.1365-2044.2000.01664-25.xJohalBKShellyMPOlanzapine overdose20005592910.1046/j.1365-2044.2000.01664-25.x10947781Open DOISearch in Google Scholar
Persson H, Sjöberg G, Haines J, de Garbino J. Poisoning severity score. Grading of acute poisoning. J Clin Toxicol 1998;36:205–13. doi: 10.3109/15563659809028940PerssonHSjöbergGHainesJdeGarbino JPoisoning severity score. Grading of acute poisoning1998362051310.3109/155636598090289409656975Open DOISearch in Google Scholar
Yeniocak S, Kalkan A, Metin D, Demirel A, Sut R, Akkoc I. Successful intravenous lipid emulsion therapy: Olanzapine intoxication. Acute Med 2018;17:96–7. PMID: 29882560YeniocakSKalkanAMetinDDemirelASutRAkkocISuccessful intravenous lipid emulsion therapy: Olanzapine intoxication201817967PMID: 2988256010.52964/AMJA.0706Search in Google Scholar
Yurtlu B, Hanci V, Gür A, Turan I. Intravenous lipid infusion restores consciousness associated with olanzapine overdose. Anesth Analg 2012;114:914–5. doi: 10.1213/ANE.0b013e318213f377YurtluBHanciVGürATuranIIntravenous lipid infusion restores consciousness associated with olanzapine overdose2012114914510.1213/ANE.0b013e318213f37722434897Open DOISearch in Google Scholar
Chue P, Singer P. A review of olanzapine-associated toxicity and fatality in overdose. J Psychiatry Neurosci 2003;28:253–61. PMCID: PMC165790ChuePSingerPA review of olanzapine-associated toxicity and fatality in overdose20032825361PMCID: PMC165790Search in Google Scholar
Lennestål R, Asplund C, Nilsson M, Lakso HA, Mjörndal T, Hägg S. Serum levels of olanzapine in a non-fatal overdose. J Anal Toxicol 2007;31:119–21. doi: 10.1093/jat/31.2.119LennestålRAsplundCNilssonMLaksoHAMjörndalTHäggSSerum levels of olanzapine in a non-fatal overdose2007311192110.1093/jat/31.2.11917536749Open DOISearch in Google Scholar
Ballestros S, Martínez M, Ballestros M, de la Torre C, Rodríguez-Borregán J. A severe case of olanzapine overdose with analytical data. Clin Toxicol (Phila) 2007;45:412–5. doi: 10.1080/15563650601072183BallestrosSMartínezMBallestrosMdela Torre CRodríguez-Borregán J. A severe case of olanzapine overdose with analytical data200745412510.1080/1556365060107218317486484Open DOISearch in Google Scholar
Hopkins L, Sunkersing J, Jaques A. Too many pills to swallow: A case of a mixed overdose. J Intensive Care Soc 2017;18:247–50. doi: 10.1177/1751143717693860HopkinsLSunkersingJJaquesAToo many pills to swallow: A case of a mixed overdose2017182475010.1177/1751143717693860566513229118840Open DOISearch in Google Scholar
Lung D, Wu A, Gerona R. Cardiotoxicity in a citalopram and olanzapine overdose. J Emerg Med 2013;45:554–8. doi: 10.1016/j.jemermed.2013.04.033LungDWuAGeronaRCardiotoxicity in a citalopram and olanzapine overdose201345554810.1016/j.jemermed.2013.04.03323871479Open DOISearch in Google Scholar