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Olanzapine poisoning in patients treated at the National Poison Control Centre in Belgrade, Serbia in 2017 and 2018: a brief review of serum concentrations and clinical symptoms

Snežana Đorđević

Snežana Đorđević

University of Defence, Military Medical Academy Medical Faculty, National Poison Control CentreBelgrade, Serbia
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Đorđević, Snežana
, 
Nataša Perković Vukčević

Nataša Perković Vukčević

University of Defence, Military Medical Academy Medical Faculty, National Poison Control CentreBelgrade, Serbia
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Vukčević, Nataša Perković
, 
Marko Antunović

Marko Antunović

University of Defence, Military Medical Academy Medical Faculty, National Poison Control CentreBelgrade, Serbia
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Antunović, Marko
, 
Vesna Kilibarda

Vesna Kilibarda

University of Defence, Military Medical Academy Medical Faculty, National Poison Control CentreBelgrade, Serbia
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Kilibarda, Vesna
, 
Gordana Vuković Ercegović

Gordana Vuković Ercegović

University of Defence, Military Medical Academy Medical Faculty, National Poison Control CentreBelgrade, Serbia
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Ercegović, Gordana Vuković
, 
Jasmina Jović Stošić

Jasmina Jović Stošić

University of Defence, Military Medical Academy Medical Faculty, National Poison Control CentreBelgrade, Serbia
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Stošić, Jasmina Jović
 and 
Slavica Vučinić

Slavica Vučinić

University of Defence, Military Medical Academy Medical Faculty, National Poison Control CentreBelgrade, Serbia
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Vučinić, Slavica
  
Jul 07, 2022
Olanzapine poisoning in patients treated at the National Poison Control Centre in Belgrade, Serbia in 2017 and 2018: a brief review of serum concentrations and clinical symptoms's Cover Image
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Article Category: Original article
Published Online: Jul 07, 2022
Page range: 126 - 130
Received: Feb 01, 2022
Accepted: May 01, 2022
DOI: https://doi.org/10.2478/aiht-2022-73-3635
Keywords
© 2022 Snežana Đorđević, Nataša Perković Vukčević, Marko Antunović, Vesna Kilibarda, Gordana Vuković Ercegović, Jasmina Jović Stošić, and Slavica Vučinić, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Figure 1

Total number of patients admitted to NPCC in 2017/18
Total number of patients admitted to NPCC in 2017/18

Figure 2

Olanzapine serum concentrations in patient 2 over four days of hospitalisation after the second admission for overdosing three months apart
Olanzapine serum concentrations in patient 2 over four days of hospitalisation after the second admission for overdosing three months apart

Figure 3

Olanzapine serum concentrations in overdosed patient 4 over six days with fatal outcome
Olanzapine serum concentrations in overdosed patient 4 over six days with fatal outcome

Figure 4

Olanzapine serum concentrations in a 50-year-old patient who ingested 120 mg of olanzapine
Olanzapine serum concentrations in a 50-year-old patient who ingested 120 mg of olanzapine

Figure 5

Creatinine kinase levels (IU/L) in hospitalised male (a) and female (b) patients with lines representing threshold values (300 IU/L for men and 200 IU/L for women)
Creatinine kinase levels (IU/L) in hospitalised male (a) and female (b) patients with lines representing threshold values (300 IU/L for men and 200 IU/L for women)

Patients with serum olanzapine concentrations above the lethal threshold of 1 mg/L

Patient Sex Age Ingested dose Time from ingestion to blood collection Concentration (mg/L) PSS
1 male 26 about 150 mg 6 h 3.40 2
2 female 26 1680 mg 5 h 2.44 3
unknown >12 h 1.75 3
3 female 59 560 mg 3 h 1.53* 4
4 male 43 unknown >24 h 1.18 3

Serum concentrations of co-ingested drugs (mg/L) during the hospitalisation

Day Olanzapine (mg/L) Clozapine (mg/L) Norclozapine (mg/L) Lamotrigine (mg/L) Midazolam (mg/L) Zolpidem (mg/L)
1 0.28 0.29 0.02 3.62 0.21 0.83
2 0.42 0.22 0.03 2.19 <LOD 0.19
3 0.59 0.49 <LOD 2.74 <LOD 0.15
4 1.53 0.68 <LOD 3.5 <LOD 0.14
5 0.31 0.7 <LOD < 1.0 <LOD 0.06
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Journal Subjects:
Medicine, Basic Medical Science, Basic Medical Science, other
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