Open Access

The assessment of parameters of convalescent plasma and their impact on COVID-19 symptoms

, , , , , ,  and   
Apr 17, 2025

Cite
Download Cover

COVID-19 Map - Johns Hopkins Coronavirus Resource Center 2021. Available at: https://coronavirus.jhu.edu/map.html (Accessed November 06, 2022). COVID-19 Map - Johns Hopkins Coronavirus Resource Center 2021 Available at: https://coronavirus.jhu.edu/map.html (Accessed November 06, 2022). Search in Google Scholar

Fischer JC, Zänker K, Van Griensven M, Schneider M, Kindgen-Milles D, Knoefel WT, Lichtenberg A, Tamaskovics B, Djiepmo-Njanang FJ, Budach W, et al. The role of passive immunization in the age of SARS-CoV-2: An update. European Journal of Medical Research. 2020;25(1). FischerJC ZänkerK Van GriensvenM SchneiderM Kindgen-MillesD KnoefelWT LichtenbergA TamaskovicsB Djiepmo-NjanangFJ BudachW The role of passive immunization in the age of SARS-CoV-2: An update European Journal of Medical Research 2020 25 1 Search in Google Scholar

Centers for Disease Control and Prevention (CDC). COVID-19 Treatments and Medications 2022. Available at: https://archive.cdc.gov/www_cdc_gov/coronavirus/2019-ncov/your-health/treatments-for-severe-illness.html (Accessed November 06, 2022). Centers for Disease Control and Prevention (CDC) COVID-19 Treatments and Medications 2022 Available at: https://archive.cdc.gov/www_cdc_gov/coronavirus/2019-ncov/your-health/treatments-for-severe-illness.html (Accessed November 06, 2022). Search in Google Scholar

Franchini M, Glingani C, De Donno G, Lucchini G, Beccaria M, Amato M, Castelli GP, Bianciardi L, Pagani M, Ghirardini M, et al. Convalescent plasma for hospitalized COVID-19 patients: A single-center experience. Life. 2022;12(3). FranchiniM GlinganiC De DonnoG LucchiniG BeccariaM AmatoM CastelliGP BianciardiL PaganiM GhirardiniM Convalescent plasma for hospitalized COVID-19 patients: A single-center experience Life 2022 12 3 Search in Google Scholar

Tobaiqy M, Qashqary M, Al-Dahery S, Mujallad A, Hershan AA, Kamal MA, Helmi N. Therapeutic management of patients with COVID-19: a systematic review. Infection Prevention in Practice. 2020;2(3). TobaiqyM QashqaryM Al-DaheryS MujalladA HershanAA KamalMA HelmiN Therapeutic management of patients with COVID-19: a systematic review Infection Prevention in Practice 2020 2 3 Search in Google Scholar

Heustess AM, Allard MA, Thompson DK, Fasinu PS. Clinical management of covid-19: A review of pharmacological treatment options. Pharmaceuticals. 2021;14(6). HeustessAM AllardMA ThompsonDK FasinuPS Clinical management of covid-19: A review of pharmacological treatment options Pharmaceuticals 2021 14 6 Search in Google Scholar

Mair-Jenkins J, Saavedra-Campos M, Baillie JK, Cleary P, Khaw FM, Lim WS, Makki S, Rooney KD, Nguyen-Van-Tam JS, Beck CR, et al. The effectiveness of convalescent plasma and hyperimmune immunoglobulin for the treatment of severe acute respiratory infections of viral etiology: A systematic review and exploratory meta-analysis. Journal of Infectious Diseases. 2015;211(1):80–90. Mair-JenkinsJ Saavedra-CamposM BaillieJK ClearyP KhawFM LimWS MakkiS RooneyKD Nguyen-Van-TamJS BeckCR The effectiveness of convalescent plasma and hyperimmune immunoglobulin for the treatment of severe acute respiratory infections of viral etiology: A systematic review and exploratory meta-analysis Journal of Infectious Diseases 2015 211 1 80 90 Search in Google Scholar

Marconato M, Abela IA, Hauser A, Schwarzmüller M, Katzensteiner R, Braun DL, Epp S, Audigé A, Weber J, Rusert P, et al. Antibodies from convalescent plasma promote SARS-CoV-2 clearance in individuals with and without endogenous antibody response. Journal of Clinical Investigation. 2022;132(12). MarconatoM AbelaIA HauserA SchwarzmüllerM KatzensteinerR BraunDL EppS AudigéA WeberJ RusertP Antibodies from convalescent plasma promote SARS-CoV-2 clearance in individuals with and without endogenous antibody response Journal of Clinical Investigation 2022 132 12 Search in Google Scholar

Zhou B, Zhong N, Guan Y. Treatment with convalescent plasma for influenza A (H5N1) infection. New England Journal of Medicine. 2007;357(14):1450–1. ZhouB ZhongN GuanY Treatment with convalescent plasma for influenza A (H5N1) infection New England Journal of Medicine 2007 357 14 1450 1 Search in Google Scholar

Ko JH, Seok H, Cho SY, Ha YE, Baek JY, Kim SH, Kim YJ, Park JK, Chung CR, Kang ES, et al. Challenges of convalescent plasma infusion therapy in Middle East respiratory coronavirus infection: A single centre experience. Antiviral Therapy. 2018;23(7):617–22. KoJH SeokH ChoSY HaYE BaekJY KimSH KimYJ ParkJK ChungCR KangES Challenges of convalescent plasma infusion therapy in Middle East respiratory coronavirus infection: A single centre experience Antiviral Therapy 2018 23 7 617 22 Search in Google Scholar

Cheng Y, Wong R, Soo YOY, Wong WS, Lee CK, Ng MHL, Chan P, Wong KC, Leung CB, Cheng G. Use of convalescent plasma therapy in SARS patients in Hong Kong. European Journal of Clinical Microbiology and Infectious Diseases. 2005;24(1):44–6. ChengY WongR SooYOY WongWS LeeCK NgMHL ChanP WongKC LeungCB ChengG Use of convalescent plasma therapy in SARS patients in Hong Kong European Journal of Clinical Microbiology and Infectious Diseases 2005 24 1 44 6 Search in Google Scholar

Hung IFN, To KKW, Lee CK, Lee KL, Chan K, Yan WW, Liu R, Watt CL, Chan WM, Lai KY, et al. Convalescent plasma treatment reduced mortality in patients with severe pandemic influenza A (H1N1) 2009 virus infection. Clinical Infectious Diseases. 2011;52(4):447–56. HungIFN ToKKW LeeCK LeeKL ChanK YanWW LiuR WattCL ChanWM LaiKY Convalescent plasma treatment reduced mortality in patients with severe pandemic influenza A (H1N1) 2009 virus infection Clinical Infectious Diseases 2011 52 4 447 56 Search in Google Scholar

van Griensven J, Edwards T, de Lamballerie X, Semple MG, Gallian P, Baize S, Horby PW, Raoul H, Magassouba N, Antierens A, et al. Evaluation of convalescent plasma for ebola virus disease in Guinea. New England Journal of Medicine. 2016;374(1):33–42. van GriensvenJ EdwardsT de LamballerieX SempleMG GallianP BaizeS HorbyPW RaoulH MagassoubaN AntierensA Evaluation of convalescent plasma for ebola virus disease in Guinea New England Journal of Medicine 2016 374 1 33 42 Search in Google Scholar

Marano G, Vaglio S, Pupella S, Facco G, Catalano L, Liumbruno GM, Grazzini G. Convalescent plasma: New evidence for an old therapeutic tool? Blood Transfusion. 2016;14(2):152–7. MaranoG VaglioS PupellaS FaccoG CatalanoL LiumbrunoGM GrazziniG Convalescent plasma: New evidence for an old therapeutic tool? Blood Transfusion 2016 14 2 152 7 Search in Google Scholar

Joyner MJ, Wright RS, Fairweather D, Senefeld JW, Bruno KA, Klassen SA, Carter RE, Klompas AM, Wiggins CC, Shepherd JRA, et al. Early safety indicators of COVID-19 convalescent plasma in 5000 patients. Journal of Clinical Investigation. 2020;130(9):4791–7. JoynerMJ WrightRS FairweatherD SenefeldJW BrunoKA KlassenSA CarterRE KlompasAM WigginsCC ShepherdJRA Early safety indicators of COVID-19 convalescent plasma in 5000 patients Journal of Clinical Investigation 2020 130 9 4791 7 Search in Google Scholar

World Health Organization (WHO). IMAI District Clinician Manual: Hospital care for adolescents and adults. World Health Organization. 2011;2(January):780. World Health Organization (WHO) IMAI District Clinician Manual: Hospital care for adolescents and adults World Health Organization 2011 2 January 780 Search in Google Scholar

Müller-Olling M, Vahlensieck U, Hilger A. Heterogeneity in COVID-19 convalescent plasma clinical trials. Clinical Pharmacology and Therapeutics. 2022;111(5):995–1000. Müller-OllingM VahlensieckU HilgerA Heterogeneity in COVID-19 convalescent plasma clinical trials Clinical Pharmacology and Therapeutics 2022 111 5 995 1000 Search in Google Scholar

Lünemann JD, Nimmerjahn F, Dalakas MC. Intravenous immunoglobulin in neurology-mode of action and clinical efficacy. Nature Reviews Neurology. 2015;11(2):80–9. LünemannJD NimmerjahnF DalakasMC Intravenous immunoglobulin in neurology-mode of action and clinical efficacy Nature Reviews Neurology 2015 11 2 80 9 Search in Google Scholar

Khan TNS, Mukry SN, Masood S, Meraj L, Devrajani BR, Akram J, Fatima N, Maqsood S, Mahesar A, Siddiqui R, et al. Usefulness of convalescent plasma transfusion for the treatment of severely ill COVID-19 patients in Pakistan. BMC Infectious Diseases. 2021;21(1). KhanTNS MukrySN MasoodS MerajL DevrajaniBR AkramJ FatimaN MaqsoodS MahesarA SiddiquiR Usefulness of convalescent plasma transfusion for the treatment of severely ill COVID-19 patients in Pakistan BMC Infectious Diseases 2021 21 1 Search in Google Scholar

Duan K, Liu B, Li C, Zhang H, Yu T, Qu J, Zhou M, Chen L, Meng S, Hu Y, et al. Effectiveness of convalescent plasma therapy in severe COVID-19 patients. Proceedings of the National Academy of Sciences of the United States of America. 2020;117(17):9490–6. DuanK LiuB LiC ZhangH YuT QuJ ZhouM ChenL MengS HuY Effectiveness of convalescent plasma therapy in severe COVID-19 patients Proceedings of the National Academy of Sciences of the United States of America 2020 117 17 9490 6 Search in Google Scholar

Alsharidah S, Ayed M, Ameen RM, Alhuraish F, Rouheldeen NA, Alshammari FR, Embaireeg A, Almelahi M, Adel M, Dawoud ME, et al. COVID-19 convalescent plasma treatment of moderate and severe cases of SARS-CoV-2 infection: A multicenter interventional study. International Journal of Infectious Diseases. 2021;103:439–46. AlsharidahS AyedM AmeenRM AlhuraishF RouheldeenNA AlshammariFR EmbaireegA AlmelahiM AdelM DawoudME COVID-19 convalescent plasma treatment of moderate and severe cases of SARS-CoV-2 infection: A multicenter interventional study International Journal of Infectious Diseases 2021 103 439 46 Search in Google Scholar

Franchini M, Glingani C, Morandi M, Corghi G, Cerzosimo S, Beduzzi G, Storti A, Di Stasi V, Rastrelli G, Vignozzi L, et al. Safety and efficacy of convalescent plasma in elderly COVID-19 patients: The RESCUE trial. Mayo Clinic Proceedings: Innovations, Quality & Outcomes. 2021;5(2):403–12. FranchiniM GlinganiC MorandiM CorghiG CerzosimoS BeduzziG StortiA Di StasiV RastrelliG VignozziL Safety and efficacy of convalescent plasma in elderly COVID-19 patients: The RESCUE trial Mayo Clinic Proceedings: Innovations, Quality & Outcomes 2021 5 2 403 12 Search in Google Scholar

Xu TM, Lin B, Chen C, Liu LG, Xue Y. Non-optimal effectiveness of convalescent plasma transfusion and hydroxychloroquine in treating COVID-19: A case report. Virology Journal. 2020;17(1). XuTM LinB ChenC LiuLG XueY Non-optimal effectiveness of convalescent plasma transfusion and hydroxychloroquine in treating COVID-19: A case report Virology Journal 2020 17 1 Search in Google Scholar

Joyner MJ, Senefeld JW, Klassen SA, Mills JR, Johnson PW, Theel ES, Wiggins CC, Bruno KA, Klompas AM, Lesser ER, et al. Effect of convalescent plasma on mortality among hospitalized patients with COVID-19: Initial three-month experience. medRxiv: the preprint server for health sciences. 2020. JoynerMJ SenefeldJW KlassenSA MillsJR JohnsonPW TheelES WigginsCC BrunoKA KlompasAM LesserER Effect of convalescent plasma on mortality among hospitalized patients with COVID-19: Initial three-month experience medRxiv: the preprint server for health sciences 2020 Search in Google Scholar

Arrieta A, Galvis AE, Morphew T, Ehwerhemuepha L, Osborne S, Enriquez C, Imfeld K, Hoang J, Nieves D, Ashouri N, et al. Safety and antibody kinetics of COVID-19 convalescent plasma for the treatment of moderate to severe cases of SARS-COV-2 infection in pediatric patients. Pediatric Infectious Disease Journal. 2021;40(7):606–11. ArrietaA GalvisAE MorphewT EhwerhemuephaL OsborneS EnriquezC ImfeldK HoangJ NievesD AshouriN Safety and antibody kinetics of COVID-19 convalescent plasma for the treatment of moderate to severe cases of SARS-COV-2 infection in pediatric patients Pediatric Infectious Disease Journal 2021 40 7 606 11 Search in Google Scholar

Kuś A, Wieczorek S, Dybko J, Szymczyk-Nużka M, Butrym A, Makuch S, Mazur G, Agrawal S. Potential of high-titre IgA convalescent plasma to improve survival and symptoms in COVID-19 patients. European Journal of Clinical Investigation. 2023;53(2):13928. KuśA WieczorekS DybkoJ Szymczyk-NużkaM ButrymA MakuchS MazurG AgrawalS Potential of high-titre IgA convalescent plasma to improve survival and symptoms in COVID-19 patients European Journal of Clinical Investigation 2023 53 2 13928 Search in Google Scholar

Verkerke H, Saeedi BJ, Boyer D, Allen JW, Owens J, Shin S, Horwath M, Patel K, Paul A, Wu SC, et al. Are we forgetting about IgA? A re-examination of coronavirus disease 2019 convalescent plasma. Transfusion. 2021;61(6):1740–8. VerkerkeH SaeediBJ BoyerD AllenJW OwensJ ShinS HorwathM PatelK PaulA WuSC Are we forgetting about IgA? A re-examination of coronavirus disease 2019 convalescent plasma Transfusion 2021 61 6 1740 8 Search in Google Scholar

Ghadami L, Hasibi M, Asadollahi-Amin A, asanjarani B, Farahmand M, Abdollahi H. Convalescent plasma therapy in patients with severe COVID-19, A single-arm, retrospective study. Microbial Pathogenesis. 2022;165. GhadamiL HasibiM Asadollahi-AminA asanjaraniB FarahmandM AbdollahiH Convalescent plasma therapy in patients with severe COVID-19, A single-arm, retrospective study Microbial Pathogenesis 2022 165 Search in Google Scholar

Wang X, Guo X, Xin Q, Pan Y, Hu Y, Li J, Chu Y, Feng Y, Wang Q. Neutralizing antibody responses to severe acute respiratory syndrome coronavirus 2 in coronavirus disease 2019 inpatients and convalescent patients. Clinical Infectious Diseases. 2020;71(10):2688–94. WangX GuoX XinQ PanY HuY LiJ ChuY FengY WangQ Neutralizing antibody responses to severe acute respiratory syndrome coronavirus 2 in coronavirus disease 2019 inpatients and convalescent patients Clinical Infectious Diseases 2020 71 10 2688 94 Search in Google Scholar

Jin JM, Bai P, He W, Wu F, Liu XF, Han DM, Liu S, Yang JK. Gender differences in patients with COVID-19: Focus on severity and mortality. Frontiers in Public Health. 2020;8. JinJM BaiP HeW WuF LiuXF HanDM LiuS YangJK Gender differences in patients with COVID-19: Focus on severity and mortality Frontiers in Public Health 2020 8 Search in Google Scholar

Schmidt AE, Vogel P, Chastain CA, Barnes T, Roth NJ, Simon TL. Analysis of 52 240 source plasma donors of convalescent COVID-19 plasma: Sex, ethnicity, and age association with initial antibody levels and rate of dissipation. Journal of Clinical Apheresis. 2022;37(5):449–59. SchmidtAE VogelP ChastainCA BarnesT RothNJ SimonTL Analysis of 52 240 source plasma donors of convalescent COVID-19 plasma: Sex, ethnicity, and age association with initial antibody levels and rate of dissipation Journal of Clinical Apheresis 2022 37 5 449 59 Search in Google Scholar

Jain S, Garg K, Tran SM, Rask IL, Tarczon M, Nandi V, Kessler DA, Strauss D, Sachais BS, Yazdanbakhsh K, et al. Characteristics of coronavirus disease 19 convalescent plasma donors and donations in the New York metropolitan area. Transfusion. 2021;61(8):2374–83. JainS GargK TranSM RaskIL TarczonM NandiV KesslerDA StraussD SachaisBS YazdanbakhshK Characteristics of coronavirus disease 19 convalescent plasma donors and donations in the New York metropolitan area Transfusion 2021 61 8 2374 83 Search in Google Scholar

Mehew J, Johnson R, Roberts D, Harvala H. Convalescent plasma for COVID-19: Male gender, older age and hospitalisation associated with high neutralising antibody levels, England, 22 April to 12 May 2020. Eurosurveillance. 2020;25(45). MehewJ JohnsonR RobertsD HarvalaH Convalescent plasma for COVID-19: Male gender, older age and hospitalisation associated with high neutralising antibody levels, England, 22 April to 12 May 2020 Eurosurveillance 2020 25 45 Search in Google Scholar

Fairweather DL, Rose NR. Women and autoimmune diseases. Emerging Infectious Diseases. 2004;10(11):2005–11. FairweatherDL RoseNR Women and autoimmune diseases Emerging Infectious Diseases 2004 10 11 2005 11 Search in Google Scholar

Foo YZ, Nakagawa S, Rhodes G, Simmons LW. The effects of sex hormones on immune function: a meta-analysis. Biological Reviews. 2017;92(1):551–71. FooYZ NakagawaS RhodesG SimmonsLW The effects of sex hormones on immune function: a meta-analysis Biological Reviews 2017 92 1 551 71 Search in Google Scholar

Rahimi-Levene N, Shapira J, Tzur I, Shiloah E, Peer V, Levin E, Izak M, Shinar E, Ziv-Baran T, Weinberger M, et al. Predictors of mortality in COVID-19 patients treated with convalescent plasma therapy. PLoS ONE. 2022;17(7 July). Rahimi-LeveneN ShapiraJ TzurI ShiloahE PeerV LevinE IzakM ShinarE Ziv-BaranT WeinbergerM Predictors of mortality in COVID-19 patients treated with convalescent plasma therapy PLoS ONE 2022 17 7 July Search in Google Scholar

Bloch EM, Shoham S, Casadevall A, Sachais BS, Shaz B, Winters JL, Van Buskirk C, Grossman BJ, Joyner M, Henderson JP, et al. Deployment of convalescent plasma for the prevention and treatment of COVID-19. Journal of Clinical Investigation. 2020;130(6):2757–65. BlochEM ShohamS CasadevallA SachaisBS ShazB WintersJL Van BuskirkC GrossmanBJ JoynerM HendersonJP Deployment of convalescent plasma for the prevention and treatment of COVID-19 Journal of Clinical Investigation 2020 130 6 2757 65 Search in Google Scholar

Hartmann J, Bloch EM, Burnouf T. Experience with COVID-19 convalescent plasma provides vital guidance to future pandemics. Transfusion. 2022;62(3):681–4. HartmannJ BlochEM BurnoufT Experience with COVID-19 convalescent plasma provides vital guidance to future pandemics Transfusion 2022 62 3 681 4 Search in Google Scholar

Language:
English
Publication timeframe:
1 times per year
Journal Subjects:
Life Sciences, Molecular Biology, Microbiology and Virology, Medicine, Basic Medical Science, Immunology