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Formulation and Evaluation of Tablets Compressed from Granules Prepared by Thermoplastic Granulation

D. Kľoc

D. Kľoc

Department of Pharmaceutical Technology, Pharmacognosy and Botany, University of Veterinary Medicine and Pharmacy in KošiceKošice, Slovak Republic
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Kľoc, D.
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T. Wolaschka

T. Wolaschka

Department of Pharmaceutical Technology, Pharmacognosy and Botany, University of Veterinary Medicine and Pharmacy in KošiceKošice, Slovak Republic
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Wolaschka, T.
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F. Ruttkay

F. Ruttkay

Department of Pharmaceutical Technology, Pharmacognosy and Botany, University of Veterinary Medicine and Pharmacy in KošiceKošice, Slovak Republic
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Ruttkay, F.
  
Jul 30, 2021
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Article Category: Special Issue Article
Published Online: Jul 30, 2021
Page range: 72 - 75
Received: Jun 15, 2021
Accepted: Jun 17, 2021
DOI: https://doi.org/10.2478/afpuc-2021-0003
Keywords
© 2021 D. Kľoc et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Figure 1

Dissolution profile of tablets A3, B3 in the acidic medium.
Dissolution profile of tablets A3, B3 in the acidic medium.

Figure 2

Dissolution profile of tablets A4, B4 in the acidic medium.
Dissolution profile of tablets A4, B4 in the acidic medium.

Figure 3

Dissolution profile of tablets A3, B3 during the whole time dissolution.
Dissolution profile of tablets A3, B3 during the whole time dissolution.

Figure 4

Dissolution profile of tablets A4, B4 during the whole time dissolution.
Dissolution profile of tablets A4, B4 during the whole time dissolution.

Composition of granules in percentages by weight_

A3 (%) A4 (%) B3 (%) B4 (%)
LAC 33 28 33 28
MCC 33 28 33 28
PEG 1500 28 38 - -
CSA - - 28 38
Stearic acid 1.5 1.5 1.5 1.5
CSD 1.5 1.5 1.5 1.5
Propranolol 3 3 3 3
Language:
English
Publication timeframe:
2 times per year
Journal Subjects:
Pharmacy, Pharmacy, other
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