<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>The aim of this formulation study was to determine the effect of the binder used in the preparation of granules by thermoplastic granulation on the release of propranolol from experimental tablets. Another aim was to select suitable excipients and their ratio in the granules to ensure a trouble-free formulation of the tablets. This study proved that the binder affects the flow properties of the granules, disintegration of the tablets and, subsequently, also the method of drug release, which can be used for the preparation of tablets with modified or prolonged drug release.</p>
</abstract>

The aim of this formulation study was to determine the effect of the binder used in the preparation of granules by thermoplastic granulation on the release of propranolol from experimental tablets. Another aim was to select suitable excipients and their ratio in the granules to ensure a trouble-free formulation of the tablets. This study proved that the binder affects the flow properties of the granules, disintegration of the tablets and, subsequently, also the method of drug release, which can be used for the preparation of tablets with modified or prolonged drug release.

Formulation and Evaluation of Tablets Compressed from Granules Prepared by Thermoplastic Granulation

Department of Pharmaceutical Technology, Pharmacognosy and Botany

University of Veterinary Medicine and Pharmacy in Košice

European Pharmaceutical Journal

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The aim of this formulation study was to determine the effect of the binder used in the preparation of granules by thermoplastic granulation on the release of...

	A3 (%)	A4 (%)	B3 (%)	B4 (%)
LAC	33	28	33	28
MCC	33	28	33	28
PEG 1500	28	38	-	-
CSA	-	-	28	38
Stearic acid	1.5	1.5	1.5	1.5
CSD	1.5	1.5	1.5	1.5
Propranolol	3	3	3	3

Formulation and Evaluation of Tablets Compressed from Granules Prepared by Thermoplastic Granulation

Article Category: Special Issue Article

Published Online: Jul 30, 2021

Page range: 72 - 75

Received: Jun 15, 2021

Accepted: Jun 17, 2021

DOI: https://doi.org/10.2478/afpuc-2021-0003

Keywords
thermoplastic granulation, propranolol dissolution, polyethylene glycol, cetyl stearyl alcohol

© 2021 D. Kľoc et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Figure 1

Figure 2

Figure 3

Figure 4

Composition of granules in percentages by weight.

Formulation and Evaluation of Tablets Compressed from Granules Prepared by Thermoplastic Granulation

Article Category: Special Issue Article

Published Online: Jul 30, 2021

Page range: 72 - 75

Received: Jun 15, 2021

Accepted: Jun 17, 2021

DOI: https://doi.org/10.2478/afpuc-2021-0003

Keywordsthermoplastic granulation, propranolol dissolution, polyethylene glycol, cetyl stearyl alcohol

© 2021 D. Kľoc et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Figure 1

Figure 2

Figure 3

Figure 4

Composition of granules in percentages by weight.

Keywords
thermoplastic granulation, propranolol dissolution, polyethylene glycol, cetyl stearyl alcohol