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Formulation and Evaluation of Tablets Compressed from Granules Prepared by Thermoplastic Granulation

D. Kľoc

D. Kľoc

Department of Pharmaceutical Technology, Pharmacognosy and Botany, University of Veterinary Medicine and Pharmacy in KošiceKošice, Slovak Republic
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Kľoc, D.
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T. Wolaschka

T. Wolaschka

Department of Pharmaceutical Technology, Pharmacognosy and Botany, University of Veterinary Medicine and Pharmacy in KošiceKošice, Slovak Republic
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Wolaschka, T.
 und 
F. Ruttkay

F. Ruttkay

Department of Pharmaceutical Technology, Pharmacognosy and Botany, University of Veterinary Medicine and Pharmacy in KošiceKošice, Slovak Republic
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Ruttkay, F.
  
30. Juli 2021
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Artikel-Kategorie: Special Issue Article
Online veröffentlicht: 30. Juli 2021
Seitenbereich: 72 - 75
Eingereicht: 15. Juni 2021
Akzeptiert: 17. Juni 2021
DOI: https://doi.org/10.2478/afpuc-2021-0003
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© 2021 D. Kľoc et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Figure 1

Dissolution profile of tablets A3, B3 in the acidic medium.
Dissolution profile of tablets A3, B3 in the acidic medium.

Figure 2

Dissolution profile of tablets A4, B4 in the acidic medium.
Dissolution profile of tablets A4, B4 in the acidic medium.

Figure 3

Dissolution profile of tablets A3, B3 during the whole time dissolution.
Dissolution profile of tablets A3, B3 during the whole time dissolution.

Figure 4

Dissolution profile of tablets A4, B4 during the whole time dissolution.
Dissolution profile of tablets A4, B4 during the whole time dissolution.

Composition of granules in percentages by weight_

A3 (%) A4 (%) B3 (%) B4 (%)
LAC 33 28 33 28
MCC 33 28 33 28
PEG 1500 28 38 - -
CSA - - 28 38
Stearic acid 1.5 1.5 1.5 1.5
CSD 1.5 1.5 1.5 1.5
Propranolol 3 3 3 3
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Englisch
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Fachgebiete der Zeitschrift:
Pharmazie, Pharmazie, andere
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