1. bookVolume 68 (2018): Issue 2 (June 2018)
Journal Details
License
Format
Journal
eISSN
1820-7448
First Published
25 Mar 2014
Publication timeframe
4 times per year
Languages
English
Open Access

MAC-Sparing Effect of Transdermal Fentanyl in Sevoflurane-Anesthetized Sheep

Published Online: 04 Jul 2018
Volume & Issue: Volume 68 (2018) - Issue 2 (June 2018)
Page range: 211 - 216
Received: 30 Jan 2018
Accepted: 26 Apr 2018
Journal Details
License
Format
Journal
eISSN
1820-7448
First Published
25 Mar 2014
Publication timeframe
4 times per year
Languages
English
Abstract

Transdermal fentanyl allows for consistent plasma concentrations of a potent synthetic μ-opioid receptor agonist and can provide constant post-operative analgesia for up to 72 h. The aim of this study was to determine the reduction of the minimum alveolar concentration of sevoflurane (MACSEVO) by transdermal fentanyl in nonpregnant ewes. Nine sheep were mask induced with sevoflurane (SEVO in oxygen). MACSEVO determinations involved electrical current applied to the lateral metacarpus as a supramaximal stimulus and measurements in duplicate. Seven days later, a fentanyl patch (75 μg/h) was applied to each sheep and 15.1 ± 1.8 h later the MAC re-determined (MACSF). MACSF was 1.99 ± 0.32 %, corresponding to 25.6 ± 8.1 % reduction from MACSEVO (P < 0.001). Transdermal fentanyl produces a significant MACSEVO-sparing effect with minimal effect on cardiovascular parameters.

Keywords

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