<abstract xmlns="http://www.w3.org/1999/xhtml">Transdermal fentanyl allows for consistent plasma concentrations of a potent synthetic μ-opioid receptor agonist and can provide constant post-operative analgesia for up to 72 h. The aim of this study was to determine the reduction of the minimum alveolar concentration of sevoflurane (MACSEVO) by transdermal fentanyl in nonpregnant ewes. Nine sheep were mask induced with sevoflurane (SEVO in oxygen). MACSEVO determinations involved electrical current applied to the lateral metacarpus as a supramaximal stimulus and measurements in duplicate. Seven days later, a fentanyl patch (75 μg/h) was applied to each sheep and 15.1 ± 1.8 h later the MAC re-determined (MACSF). MACSF was 1.99 ± 0.32 %, corresponding to 25.6 ± 8.1 % reduction from MACSEVO (<italic>P</italic> &lt; 0.001). Transdermal fentanyl produces a significant MACSEVO-sparing effect with minimal effect on cardiovascular parameters.</abstract>

Transdermal fentanyl allows for consistent plasma concentrations of a potent synthetic μ-opioid receptor agonist and can provide constant post-operative analgesia for up to 72 h. The aim of this study was to determine the reduction of the minimum alveolar concentration of sevoflurane (MACSEVO) by transdermal fentanyl in nonpregnant ewes. Nine sheep were mask induced with sevoflurane (SEVO in oxygen). MACSEVO determinations involved electrical current applied to the lateral metacarpus as a supramaximal stimulus and measurements in duplicate. Seven days later, a fentanyl patch (75 μg/h) was applied to each sheep and 15.1 ± 1.8 h later the MAC re-determined (MACSF). MACSF was 1.99 ± 0.32 %, corresponding to 25.6 ± 8.1 % reduction from MACSEVO (P < 0.001). Transdermal fentanyl produces a significant MACSEVO-sparing effect with minimal effect on cardiovascular parameters.

MAC-Sparing Effect of Transdermal Fentanyl in Sevoflurane-Anesthetized Sheep

Department of Clinical Studies, New Bolton Center

University of Pennsylvania, School of Veterinary Medicine

Centro di Ricerca di Chirurgia Comparata (CRCC)

Acta Veterinaria

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"MAC-Sparing Effect of Transdermal Fentanyl in Sevoflurane-Anesthetized Sheep"}

Transdermal fentanyl allows for consistent plasma concentrations of a potent synthetic μ-opioid receptor agonist and can provide constant post-operative...

MAC-Sparing Effect of Transdermal Fentanyl in Sevoflurane-Anesthetized Sheep

Published Online: Jul 04, 2018

Page range: 211 - 216

Received: Jan 30, 2018

Accepted: Apr 26, 2018

DOI: https://doi.org/10.2478/acve-2018-0015

Keywords
Minimum alveolar concentration (MAC), sevoflurane, sheep, transdermal fentanyl

© 2018 Duffee Lauren et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

MAC-Sparing Effect of Transdermal Fentanyl in Sevoflurane-Anesthetized Sheep

Published Online: Jul 04, 2018

Page range: 211 - 216

Received: Jan 30, 2018

Accepted: Apr 26, 2018

DOI: https://doi.org/10.2478/acve-2018-0015

KeywordsMinimum alveolar concentration (MAC), sevoflurane, sheep, transdermal fentanyl

© 2018 Duffee Lauren et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
Minimum alveolar concentration (MAC), sevoflurane, sheep, transdermal fentanyl