This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Y. Vinik, H. Shatz-Azoulay and Y. Zick, Molecular mechanisms underlying the role of galectin-8 as a regulator of cancer growth and metastasis, Trends Glycosci. Glycotechnol.30(172) (2018) SE119– SE128; https://doi.org/10.4052/tigg.1742.1SESearch in Google Scholar
Y. R. Hadari, K. Paz, R. Dekel, T. Mestrovic, D. Accili and Y. Zick, Galectin-8: A new rat lectin, re-lated to galectin-4, J. Biol. Chem.270(7) (1995) 3447–3453; https://doi.org/10.1074/jbc.270.7.3447Search in Google Scholar
Y. R. Hadari, R. Arbel-Goren, Y. Levy, A. Amsterdam, R. Alon, R. Zakut and Y. Zick, Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis, J. Cell Sci.113(13) (2000) 2385–2397; https://doi.org/10.1242/jcs.113.13.2385Search in Google Scholar
R. V. Gopalkrishnan, T. Roberts, S. Tuli, D. C. Kang, K. A. Christiansen and P. B. Fisher, Molecular characterization of prostate carcinoma tumor antigen-1, PCTA-1, a human galectin-8 related gene, Oncogene19(38) (2000) 4405–4416; https://doi.org/10.1038/sj.onc.1203767Search in Google Scholar
R. D. Cummings, F.-T. Liu, G. A. Rabinovich, S. R. Stowell and G. R. Vasta, Galectins, in Carbohydrates in Chemistry and Biology4–4, Wiley Online Library, 2022, pp. 625–647; https://doi.org/10.1002/9783527618255Search in Google Scholar
E. Purić, U. J. Nilsson and M. Anderluh, Galectin-8 inhibition and functions in immune response and tumor biology, Med. Res. Rev.44(5) (2024) 2236–2265; https://doi.org/10.1002/med.22041Search in Google Scholar
P. Sörme, B. Kahl-Knutson, U. Wellmar, U. J. Nilsson and H. Leffler, Fluorescence polarization to study galectin-ligand interactions, Methods Enzymol.362 (2003) 504–512; https://doi.org/10.1016/S0076-6879(03)01033-4Search in Google Scholar
P. Sörme, B. Kahl-Knutson, M. Huflejt, U. J. Nilsson and H. Leffler, Fluorescence polarization as an analytical tool to evaluate galectin-ligand interactions, Anal. Biochem.334 (2004) 36–47; https://doi.org/10.1016/j.ab.2004.06.042Search in Google Scholar
S. Carlsson, C. T. Öberg, M. C. Carlsson, A. Sundin, U. J. Nilsson, D. Smith, R. D. Cummings, J. Almkvist, A. Karlsson and H. Leffler, Affinity of galectin-8 and its carbohydrate recognition do-mains for ligands in solution and at the cell surface, Glycobiology17(6) (2007) 663–676; https://doi.org/10.1093/glycob/CWM026Search in Google Scholar
C. T. Öberg, S. Carlsson, E. Fillion, H. Leffler and U. J. Nilsson, Efficient and expedient two-step pyranose-retaining fluorescein conjugation of complex reducing oligosaccharides: Galectin oligo-saccharide specificity studies in a fluorescence polarization assay, Bioconjug. Chem.14(6) (2003) 1289–1297; https://doi.org/10.1021/bc034130JSearch in Google Scholar
W. A. Lea and A. Simeonov, Fluorescence polarization assays in small molecule screening, Expert Opin. Drug Discov.6(1) (2011) 17–32; https://doi.org/10.1517/17460441.2011.537322Search in Google Scholar
M. D. Hall, A. Yasgar, T. Peryea, J. C. Braisted, A. Jadhav, A. Simeonov and N. P. Coussens, Fluores-cence polarization assays in high-throughput screening and drug discovery: A review, Methods Appl. Fluoresc.4(2) (2016) Article ID 022001; https://doi.org/10.1088/2050-6120/4/2/022001Search in Google Scholar
E. A. Howe, A. De Souza, D. L. Lahr, S. Chatwin, P. Montgomery, B. R. Alexander, D. T. Nguyen, Y. Cruz, D. A. Stonich, G. Walzer, J. T. Rose, S. C. Picard, Z. Liu, J. N. Rose, X. Xiang, J. Asiedu, D. Dur-kin, J. Levine, J. J. Yang, S. C. Schürer, J. C. Braisted, N. Southall, M. R. Southern, T. D. Y. Chung, S. Brudz, C. Tanega, S. L. Schreiber, J. A. Bittker, R. Guha and P. A. Clemons, BioAssay Research Data-base (BARD): chemical biology and probe-development enabled by structured metadata and result types, Nucleic Acids Res.43 (2015) D1163–D1170; https://doi.org/10.1093/nar/gku1244Search in Google Scholar
E. Purić, M. Hassan, F. Sjövall, T. Tomašič, M. Pevec, J. Lah, J. A. Forteza, A. Sundin, H. Leffler, U. J. Nilsson, D. T. Logan and M. Anderluh, Nanomolar inhibitor of the galectin-8 N-terminal domain binds via a non-canonical cation-π interaction, Commun. Chem.8(1) (2025) Article ID 59 (11 pages); https://doi.org/10.1038/s42004-025-01458-6Search in Google Scholar
K. B. Pal, M. Mahanti, X. Huang, S. Persson, A. P. Sundin, F. R. Zetterberg, S. Oredsson, H. Leffler and U. J. Nilsson, Quinoline-galactose hybrids bind selectively with high affinity to a galectin-8 N-terminal domain, Org. Biomol. Chem.16(34) (2018) 6295–6305; https://doi.org/10.1039/C8OB01354CSearch in Google Scholar
M. Hassan, S. van Klaveren, M. Håkansson, C. Diehl, R. Kovačič, F. Baussière, A. P. Sundin, J. Dernovšek, B. Walse, F. Zetterberg, H. Leffler, M. Anderluh, T. Tomašič, Ž. Jakopin and U. J. Nilsson, Benzimidazole-galactosides bind selectively to the galectin-8 N-terminal domain: Structure-based design and optimisation, Eur. J. Med. Chem.223 (2021) Article ID 113664 (13 pages); https://doi.org/10.1016/j.ejmech.2021.113664Search in Google Scholar
M. Hassan, F. Baussière, S. Guzelj, A. P. Sundin, M. Håkansson, R. Kovačič, H. Leffler, T. Tomašič, M. Anderluh, Ž. Jakopin and U. J. Nilsson, Structure-guided design of d -galactal derivatives with high affinity and selectivity for the galectin-8 N-terminal domain, ACS Med. Chem. Lett.12(11) (2021) 1745–1752; https://doi.org/10.1021/acsmedchemlett.1c00371Search in Google Scholar
B. Girardi, M. Manna, S. Van Klaveren, T. Tomašič, Ž. Jakopin, H. Leffler, U. J. Nilsson, D. Ricklin, J. Mravljak, O. Schwardt and M. Anderluh, Selective monovalent galectin-8 ligands based on 3-lact-oylgalactoside, ChemMedChem17(3) (2022) Article ID e202100514; https://doi.org/10.1002/cmdc.202100514Search in Google Scholar
K. M. Craft and S. D. Townsend, Synthesis of lacto-N-tetraose, Carbohydr. Res.440–441 (2017) 43–50; https://doi.org/10.1016/j.carres.2017.02.001Search in Google Scholar
J. H. Zhang, T. D. Y. Chung and K. R. Oldenburg, A simple statistical parameter for use in evaluation and validation of high throughput screening assays, SLAS Discovery4(2) (1999) 67–73; https://doi.org/10.1177/108705719900400206Search in Google Scholar