Alternative buffer systems in biopharmaceutical formulations and their effect on protein stability

Novartis, Global Drug Development, Technical Research & Development Biologics, Drug Product Development, Formulation Development Lek Pharmaceuticals d.d.Ljubljana, Slovenia

Zidar, Mitja

Novartis, Global Drug Development, Technical Research & Development Biologics, Drug Product Development, Formulation Development Lek Pharmaceuticals d.d.Ljubljana, Slovenia

Mravljak, Janez

University of Ljubljana Faculty of Pharmacy, Department of Pharmaceutical ChemistryLjubljana, Slovenia

Šink, Roman

Novartis, Global Drug Development, Technical Research & Development Biologics, Drug Product Development, Formulation Development Lek Pharmaceuticals d.d.Ljubljana, Slovenia

Žula, Aleš

Novartis, Global Drug Development, Technical Research & Development Biologics, Drug Product Development, Formulation Development Lek Pharmaceuticals d.d.Ljubljana, Slovenia

Pajk, Stane

University of Ljubljana Faculty of Pharmacy, Department of Pharmaceutical ChemistryLjubljana, Slovenia

Language:: English

Publication timeframe:: 4 times per year
Journal Subjects:: Pharmacy, Pharmacy, other

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Alternative buffer systems in biopharmaceutical formulations and their effect on protein stability

Blaž Lebar

Mitja Zidar

Janez Mravljak

Roman Šink

Aleš Žula

Stane Pajk

Published Online: Sep 14, 2024

Page range: 479 - 493

Accepted: May 02, 2024

DOI: https://doi.org/10.2478/acph-2024-0022

Keywordsbiopharmaceuticals, buffer, stress, aggregates, alternative buffers, stability

© 2024 Blaž Lebar et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
biopharmaceuticals, buffer, stress, aggregates, alternative buffers, stability