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Improvement in school absence after factor replacement in students with haemophilia in Upper Assam, India

Anupam Dutta

Anupam Dutta

Department of Medicine, Assam Medical College and HospitalDibrugarh, India
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Dutta, Anupam
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Dipjyoti Boruah

Dipjyoti Boruah

Department of Medicine, Assam Medical College and HospitalDibrugarh, India
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Boruah, Dipjyoti
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Taniya Sarkar Dutta

Taniya Sarkar Dutta

Department of Paediatrics, Assam Medical College and HospitalDibrugarh, India
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Dutta, Taniya Sarkar
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Angshuman Boruah

Angshuman Boruah

Department of Medicine, Assam Medical College and HospitalDibrugarh, India
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Boruah, Angshuman
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Bhabani Shankar Dhal

Bhabani Shankar Dhal

Department of Medicine, Assam Medical College and HospitalDibrugarh, India
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Dhal, Bhabani Shankar
  
Nov 19, 2020
Improvement in school absence after factor replacement in students with haemophilia in Upper Assam, India's Cover Image
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Article Category: Clinical Research
Published Online: Nov 19, 2020
Page range: 136 - 142
DOI: https://doi.org/10.17225/jhp00166
Keywords
© 2020 Anupam Dutta et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
In countries with limited resources, a regimen of low dose prophylaxis or access to on-demand therapy with factor replacement can help to improve bleeding rates, joint health and functional ability for children with haemophilia, thereby improving school attendance.
In countries with limited resources, a regimen of low dose prophylaxis or access to on-demand therapy with factor replacement can help to improve bleeding rates, joint health and functional ability for children with haemophilia, thereby improving school attendance.

Characteristics of participants

VARIABLEPROPHYLAXIS MEAN (±SD)ON-DEMAND MEAN (±SD)
Age at enrolment (years)13.1(±4.5)11.7(+4.5)
Duration of prophylaxis (years)1.4(±0.2)–
Haemophilia type
Haemophilia A2110
Haemophilia B52

Correlation between school absences and ABR, HJHS and FISH during prophylaxis and on-demand treatment

BEFORE ENROLMENTP-VALUEAFTER ENROLMENTP-VALUE
Prophylaxis
ABR0.5140.0090.639<0.001
HJHS0.3250.1120.1560.446
FISH−0.751<0.001−0.694<0.001
On-demand
ABR0.874<0.0010.3960.203
HJHS0.6900.0130.1970.539
FISH−0.7980.002−0.5800.048

Days of school absence (per month) in the year before and after enrolment with HTC

VARIABLEBEFORE ENROLMENT MEAN(±SD)AFTER ENROLMENT MEAN(±SD)P-VALUE*
Number of days absent (prophylaxis)15(+6)4(+3)<0.001
Number of days absent (on-demand)10(+5)3(+2)0.477
Scores during prophylaxis
ABR37.8(±20.0)5.8(±4.6)<0.001
HJHS31.1(±18.1)4.7(±4.6)<0.001
FISH21.4(±4.2)27.9(±3.3)<0.001
Scores during on-demand treatment
ABR25.5(±19.9)8.7(±6.2)0.006
HJHS13.8(±11.4)3.1(±4.2)0.002
FISH24.6(±4.5)29.1(±2.6)<0.001
Language:
English
Publication timeframe:
1 times per year
Journal Subjects:
Medicine, Basic Medical Science, Basic Medical Science, other, Clinical Medicine, Clinical Medicine, other, Pharmacy, Pharmacology
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