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Prevalence, pattern and clinical implications of transfusion transmissible viral infections among paediatric haemophiliacs in northern Nigeria

Sagir G. Ahmed

Sagir G. Ahmed

Department of Haematology, Aminu Kano Teaching HospitalKano, Nigeria
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Ahmed, Sagir G.
, 
Umma A. Ibrahim

Umma A. Ibrahim

Department of Paediatrics, Aminu Kano Teaching HospitalKano, Nigeria
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Ibrahim, Umma A.
 and 
Modu B. Kagu

Modu B. Kagu

Department of Haematology, University of Maiduguri Teaching HospitalMaiduguri, Nigeria
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Kagu, Modu B.
  
Jan 18, 2019
Prevalence, pattern and clinical implications of transfusion transmissible viral infections among paediatric haemophiliacs in northern Nigeria's Cover Image
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Article Category: Evidence Review
Published Online: Jan 18, 2019
Page range: 103 - 110
DOI: https://doi.org/10.17225/jhp00117
Keywords
© 2019 Sagir G. Ahmed, Umma A. Ibrahim, Modu B. Kagu published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Image: Fresh whole blood remains a mainstay of treatment for haemophilia in Nigeria, although the country’s blood transfusion service is underdeveloped and donor screening is limited© Shutterstock
Image: Fresh whole blood remains a mainstay of treatment for haemophilia in Nigeria, although the country’s blood transfusion service is underdeveloped and donor screening is limited© Shutterstock
Image: For many people with haemophilia in Nigeria, first-line treatment is accessed through sub-tertiary hospitals with limited resources. Tertiary hospitals are generally located in cities, expensive and less accessible to patients and their carers© Shutterstock
Image: For many people with haemophilia in Nigeria, first-line treatment is accessed through sub-tertiary hospitals with limited resources. Tertiary hospitals are generally located in cities, expensive and less accessible to patients and their carers© Shutterstock
Image: A significant number of paediatric haemophiliacs in Nigeria are already infected with one or more transfusion transmissible viral infections by the time they attend a tertiary hospital, after receiving multiple blood transfusions at sub-tertiary hospitals© Shutterstock
Image: A significant number of paediatric haemophiliacs in Nigeria are already infected with one or more transfusion transmissible viral infections by the time they attend a tertiary hospital, after receiving multiple blood transfusions at sub-tertiary hospitals© Shutterstock

Pattern and frequencies of infections among 24 paediatric haemophiliacs with transfusion transmissible viral infections (TTVIs)

TTVINUMBER OF PATIENTS INFECTED (%)
HBV10 (41.7)
HIV-15 (20.8)
HCV4 (16.7)
HBV and HIV-13 (12.5)
HBV and HCV2 (8.3)
All infections24 (100)

Age, disease severity and number of previous transfusions among 97 haemophiliacs with and without transfusion transmissible viral infections (TTVIs)

PARAMETERSHAEMOPHILIACS WITHTTVIS (N=24)HAEMOPHILIACSWITHOUT TTVIS (N=73)P-VALUES
Age in years (mean ± SD)4.9 ± 1.07.8 ± 1.6p=0.007
Number of patients (%) with severe haemophilia15 (62.5)19 (26)p=0.009
Number of previous transfusions per patient (mean ± SD)27.5 ± 4.215.3± 3.5p=0.006
Language:
English
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1 times per year
Journal Subjects:
Medicine, Basic Medical Science, Basic Medical Science, other, Clinical Medicine, Clinical Medicine, other, Pharmacy, Pharmacology
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