This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
Mir LM, Orlowski S. Mechanisms of electrochemotherapy. Adv Drug Deliv Rev 1999; 35: 107–18.MirLMOrlowskiSMechanisms of electrochemotherapyAdv Drug Deliv Rev1999351071810.1016/S0169-409X(98)00066-0Search in Google Scholar
Belehradek M, Domenge C, Luboinski B, Orlowski S, Belehradek J, Mir LM. Electrochemotherapy, a new antitumor treatment. First clinical phase I-II trial. Cancer 1993; 72: 3694–700BelehradekMDomengeCLuboinskiBOrlowskiSBelehradekJMirLMElectrochemotherapy, a new antitumor treatment. First clinical phase I-II trialCancer199372369470010.1002/1097-0142(19931215)72:12<3694::AID-CNCR2820721222>3.0.CO;2-2Search in Google Scholar
Mali B, Jarm T, Snoj M, Sersa G, Miklavcic D. Antitumor effectiveness of electrochemotherapy: A systematic review and meta-analysis. Eur J Surg Oncol 2013; 39: 4–16MaliBJarmTSnojMSersaGMiklavcicDAntitumor effectiveness of electrochemotherapy: A systematic review and meta-analysisEur J Surg Oncol20133941610.1016/j.ejso.2012.08.016Search in Google Scholar
Mir LM, Glass LF, Sersa G, Teissié J, Domenge C, Miklavcic D, et al. Effective treatment of cutaneous and subcutaneous malignant tumours by electrochemotherapy. Br J Cancer 1998; 77: 2336–42MirLMGlassLFSersaGTeissiéJDomengeCMiklavcicDEffective treatment of cutaneous and subcutaneous malignant tumours by electrochemotherapyBr J Cancer19987723364210.1038/bjc.1998.388Search in Google Scholar
Mir LM. Therapeutic perspectives of in vivo cell electropermeabilization. Bioelectrochemistry 2001; 53: 1–10MirLMTherapeutic perspectives of in vivo cell electropermeabilizationBioelectrochemistry20015311010.1016/S0302-4598(00)00112-4Search in Google Scholar
Gothelf A, Mir LM, Gehl J. Electrochemotherapy: results of cancer treatment using enhanced delivery of bleomycin by electroporation. Cancer Treat Rev. 2003; 29: 371–87GothelfAMirLMGehlJElectrochemotherapy: results of cancer treatment using enhanced delivery of bleomycin by electroporationCancer Treat Rev.2003293718710.1016/S0305-7372(03)00073-2Search in Google Scholar
Chen C, Smye SW, Robinson MP, Evans JA. Membrane electroporation theories: a review. Med Biol Eng Comput 2006; 44: 5–14ChenCSmyeSWRobinsonMPEvansJAMembrane electroporation theories: a reviewMed Biol Eng Comput20064451410.1007/s11517-005-0020-2Search in Google Scholar
Marty M, Sersa G, Garbay JR, Gehl J, Collins CG, Snoj M, et al. Electrochemotherapy–An easy, highly effective and safe treatment of cutaneous and subcutaneous metastases: Results of ESOPE (European Standard Operating Procedures of Electrochemotherapy) study. Eur J Cancer Suppl 2006; 4: 3–13MartyMSersaGGarbayJRGehlJCollinsCGSnojMElectrochemotherapy–An easy highly effective and safe treatment of cutaneous and subcutaneous metastases: Results of ESOPE (European Standard Operating Procedures of Electrochemotherapy) studyEur J Cancer Suppl2006431310.1016/j.ejcsup.2006.08.002Search in Google Scholar
Campana L, Mocellin S, Basso M, Puccetti O, De Salvo G, Chiarion-Sileni V, et al. Bleomycin-based electrochemotherapy: clinical outcome from a single institution’s experience with 52 patients. Ann Surg Oncol 2009; 16: 191–9CampanaLMocellinSBassoMPuccettiODe SalvoGChiarion-SileniVBleomycin-based electrochemotherapy: clinical outcome from a single institution’s experience with 52 patientsAnn Surg Oncol200916191910.1245/s10434-008-0204-8Search in Google Scholar
Campana L, Valpione S, Falci C, Mocellin S, Basso M, Corti L, et al. The activity and safety of electrochemotherapy in persistent chest wall recurrence from breast cancer after mastectomy: a phase-II study. Breast Cancer Res Treat 2012; 134:1169-78.CampanaLValpioneSFalciCMocellinSBassoMCortiLThe activity and safety of electrochemotherapy in persistent chest wall recurrence from breast cancer after mastectomy: a phase-II studyBreast Cancer Res Treat201213411697810.1007/s10549-012-2095-4Search in Google Scholar
Campana L, Bianchi G, Mocellin S, Valpione S, Campanacci L, Brunello A, et al. Electrochemotherapy treatment of locally advanced and metastatic soft tissue sarcomas: results of a non-comparative phase II study. World J Surg 2014: 38: 813–22CampanaLBianchiGMocellinSValpioneSCampanacciLBrunelloAElectrochemotherapy treatment of locally advanced and metastatic soft tissue sarcomas: results of a non-comparative phase II studyWorld J Surg2014388132210.1007/s00268-013-2321-124170155Search in Google Scholar
Valpione S, Campana LG, Pigozzo J, Chiarion-Sileni V. Consolidation electrochemotherapy with bleomycin in metastatic melanoma during treatment with dabrafenib. Radiol Oncol 2015; 49: 71–4.ValpioneSCampanaLGPigozzoJChiarion-SileniVConsolidation electrochemotherapy with bleomycin in metastatic melanoma during treatment with dabrafenibRadiol Oncol20154971410.2478/raon-2014-0035436260925810704Search in Google Scholar
Campana LG, Scarpa M, Sommariva A, Bonandini E, Valpione S, Sartore L, Rossi CR. Minimally invasive treatment of peristomal metastases from gastric cancer at an ileostomy site by electrochemotherapy. Radiol Oncol 2013; 47: 370–5CampanaLGScarpaMSommarivaABonandiniEValpioneSSartoreLRossiCRMinimally invasive treatment of peristomal metastases from gastric cancer at an ileostomy site by electrochemotherapyRadiol Oncol201347370510.2478/raon-2013-0051381428224294182Search in Google Scholar
Buchanan CL, Dorn PL, Fey J, Giron G, Naik A, Mendez J, et al. Locoregional recurrence after mastectomy: incidence and outcomes. J Am Coll Surg. 2006; 203: 469–74BuchananCLDornPLFeyJGironGNaikAMendezJLocoregional recurrence after mastectomy: incidence and outcomesJ Am Coll Surg.20062034697410.1016/j.jamcollsurg.2006.06.01517000389Search in Google Scholar
Schmoor C, Sauerbrei W, Bastert G, Schumacher M. Role of isolated locoregional recurrence of breast cancer: results of four prospective studies. J Clin Oncol 2000; 18: 1696–708SchmoorCSauerbreiWBastertGSchumacherMRole of isolated locoregional recurrence of breast cancer: results of four prospective studiesJ Clin Oncol200018169670810.1200/JCO.2000.18.8.169610764430Search in Google Scholar
Andry G, Suciu S, Vico P, Faverly D, Andry-t’Hooft M, et al. Locoregional recurrences after 649 modified radical mastectomies: incidence and significance. Eur J Surg Oncol 1989; 15: 476–85AndryGSuciuSVicoPFaverlyDAndry-t’HooftMLocoregional recurrences after 649 modified radical mastectomies: incidence and significanceEur J Surg Oncol19891547685Search in Google Scholar
Cheng SH, Horng CF, Clarke JL, Tsou MH, Tsai SY, Chen CM, et al. Prognostic index score and clinical prediction model of local regional recurrence after mastectomy in breast cancer patients. Int J Radiat Oncol Biol Phys 2006; 64: 1401–9ChengSHHorngCFClarkeJLTsouMHTsaiSYChenCMPrognostic index score and clinical prediction model of local regional recurrence after mastectomy in breast cancer patientsInt J Radiat Oncol Biol Phys2006641401910.1016/j.ijrobp.2005.11.01516472935Search in Google Scholar
Nielsen HM, Overgaard M, Grau C, Jensen AR, Overgaard J. Loco-regional recurrence after mastectomy in high-risk breast cancer--risk and prognosis. An analysis of patients from the DBCG 82 b&c randomization trials. Radiother Oncol 2006; 79: 147–55NielsenHMOvergaardMGrauCJensenAROvergaardJLoco-regional recurrence after mastectomy in high-risk breast cancer--risk and prognosis. An analysis of patients from the DBCG 82 b&c randomization trialsRadiother Oncol2006791475510.1016/j.radonc.2006.04.00616647152Search in Google Scholar
Sersa G, Cufer T, Paulin SM, Cemazar M, Snoj M. Electrochemotherapy of chest wall breast cancer recurrence. Cancer Treat Rev 2012; 38: 379–86SersaGCuferTPaulinSMCemazarMSnojMElectrochemotherapy of chest wall breast cancer recurrenceCancer Treat Rev2012383798610.1016/j.ctrv.2011.07.00621856080Search in Google Scholar
Campana LG, Falci C, Basso M, Sieni E, Dughiero F. Clinical electrochemotherapy for chest wall recurrence from breast cancer. In: Sundarajan R, editor. Electroporation-based therapies for cancer. Elsevier; 2014. p. 3–33CampanaLGFalciCBassoMSieniEDughieroFClinical electrochemotherapy for chest wall recurrence from breast cancerSundarajanReditorElectroporation-based therapies for cancerElsevier201433310.1533/9781908818294.3Search in Google Scholar
Mir LM, Gehl J, Sersa G, Collins CG, Garbay J-R, Billard V, et al. Standard operating procedures of the electrochemotherapy: Instructions for the use of bleomycin or cisplatin administered either systemically or locally and electric pulses delivered by the CliniporatorTM by means of invasive or non-invasive electrodes. EJC Suppl 2006; 4: 14–25MirLMGehlJSersaGCollinsCGGarbayJ-RBillardVStandard operating procedures of the electrochemotherapy: Instructions for the use of bleomycin or cisplatin administered either systemically or locally and electric pulses delivered by the CliniporatorTM by means of invasive or non-invasive electrodesEJC Suppl20064142510.1016/j.ejcsup.2006.08.003Search in Google Scholar
Heller R, Jaroszeski MJ, Gilbert R. Electromanipulation device and method. 2010. USA Patent 7,769,440HellerRJaroszeskiMJGilbertRElectromanipulation device and method2010USA Patent 7,769,440Search in Google Scholar
Ferraro B, Heller LC, Cruz YL, Guo S, Donate A, Heller R. Evaluation of delivery conditions for cutaneous plasmid electrotransfer using a multielectrode array. Gene Therapy 2011; 18: 496–500FerraroBHellerLCCruzYLGuoSDonateAHellerREvaluation of delivery conditions for cutaneous plasmid electrotransfer using a multielectrode arrayGene Therapy20111849650010.1038/gt.2010.171Search in Google Scholar
Heller R, Cruz Y, Heller LC, Gilbert RA, Jaroszeski MJ. Electrically mediated delivery of plasmid DNA to the skin, using a multielectrode array. Hum Gene Ther 2010; 21: 357–62HellerRCruzYHellerLCGilbertRAJaroszeski MJ. Electrically mediated delivery of plasmid DNA to the skin using a multielectrode arrayHum Gene Ther2010213576210.1089/hum.2009.065Search in Google Scholar
Bommakanti S, Agoramurthy P, Campana L, Sundararajan R. A simulation analysis of large multi-electrode needle arrays for efficient electrochemotherapy of cancer tissues. In: Electrical Insulation and Dielectric Phenomena (CEIDP), 2011 Annual report conference on electrical insulation and dielectric phenomena. Cancun, Mexico 2011: 187–90 doi:10.1109/CEIDP.2011.6232628.BommakantiSAgoramurthyPCampanaLSundararajanRA simulation analysis of large multi-electrode needle arrays for efficient electrochemotherapy of cancer tissuesElectrical Insulation and Dielectric Phenomena (CEIDP), 2011 Annual report conference on electrical insulation and dielectric phenomena. Cancun, Mexico20111879010.1109/CEIDP.2011.6232628Open DOISearch in Google Scholar
Agoramurthy P, Campana L, Sundararajan R. Finite element modeling and analysis of human breast tissue for electrochemotherapy. In: IEEE; 2011: 191–4 doi:10.1109/CEIDP.2011.6232629.AgoramurthyPCampanaLSundararajanRFinite element modeling and analysis of human breast tissue for electrochemotherapyIEEE2011191410.1109/CEIDP.2011.6232629Open DOISearch in Google Scholar
Gilbert RA, Jaroszeski MJ, Heller R. Novel electrode designs for electrochemotherapy. Biochim Biophys Acta 1997; 1334: 9–14GilbertRAJaroszeskiMJHellerRNovel electrode designs for electrochemotherapyBiochim Biophys Acta1997133491410.1016/S0304-4165(96)00119-5Search in Google Scholar
Castiello M, Dughiero F, Scandola F, Sieni E, Campana LG, Rossi CR, et al. A new grid electrode for electrochemotherapy treatment of large skin tumors. Dielectrics and Electrical Insulation, IEEE Transactions on Electrical Insulation and Dielectric Phenomena. 2014; 21(3): 1424–32 doi:10.1109/TDEI.2014.6832291.CastielloMDughieroFScandolaFSieniECampanaLGRossiCRA new grid electrode for electrochemotherapy treatment of large skin tumorsDielectrics and Electrical Insulation IEEE Transactions on Electrical Insulation and Dielectric Phenomena201421(3)14243210.1109/TDEI.2014.6832291Open DOISearch in Google Scholar
Nenzi P, Denzi A, Kholostov K, Crescenzi R, Apollonio F, Liberti M, et al. Smart flexible planar electrodes for electrochemotherapy and biosensing. Electronic Components and Technology Conference (ECTC), 2013 IEEE 63rd. May 2013: 486–93 doi:10.1109/ECTC.2013.6575616.NenziPDenziAKholostovKCrescenziRApollonioFLibertiMSmart flexible planar electrodes for electrochemotherapy and biosensingElectronic Components and Technology Conference (ECTC), 2013 IEEE 63rd.May20134869310.1109/ECTC.2013.6575616Open DOISearch in Google Scholar
Ongaro A, Campana LG, De Mattei M, Dughiero F, Forzan MM, Pellati A, et al. Evaluation of the electroporation efficiency of a grid electrode for electrochemotherapy: from numerical model to in vitro tests. Technol Cancer Res Treatm. In press. doi: 10.1177/1533034615582350OngaroACampanaLGDe MatteiMDughieroFForzanMMPellatiAEvaluation of the electroporation efficiency of a grid electrode for electrochemotherapy: from numerical model to in vitro testsTechnol Cancer Res Treatm.10.1177/153303461558235025911645Open DOISearch in Google Scholar
Ongaro A, Campana LG, De Mattei M, Dughiero F, Forzan M, Pellati A, et al. Effect of electrode distance in electrochemotherapy: from numerical model to in vitro tests. In: Jarm T, Kramar P, eds. 1st World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food & Environmental Technologies. Vol 53. IFMBE Proceedings. Singapore: Springer; 2016. p. 167–70 Available at: http://dx.doi.org/10.1007/978-981-287-817-5_37.OngaroACampanaLGDe MatteiMDughieroFForzanMPellatiAEffect of electrode distance in electrochemotherapy: from numerical model to in vitro testsJarmTKramarPeds1st World Congress on Electroporation and Pulsed Electric Fields in Biology Medicine and Food & Environmental Technologies.Vol 53IFMBE ProceedingsSingaporeSpringer201616770Available athttp://dx.doi.org/10.1007/978-981-287-817-5_3710.1007/978-981-287-817-5_37Search in Google Scholar
IGEA. [Cited 15 Apr 2014]. Available at: http://www.igeamedical.com/.IGEA. [Cited 15 Apr 2014]Available athttp://www.igeamedical.com/Search in Google Scholar
Bertacchini C, Margotti PM, Bergamini E, Lodi A, Ronchetti M, Cadossi R. Design of an irreversible electroporation system for clinical use. Technol Cancer Res Treat 2007; 6: 313–20BertacchiniCMargottiPMBergaminiELodiARonchettiMCadossiRDesign of an irreversible electroporation system for clinical useTechnol Cancer Res Treat200763132010.1177/15330346070060040817668939Search in Google Scholar
Hjouj M, Rubinsky B. Magnetic resonance imaging characteristics of non-thermal irreversible electroporation in vegetable tissue. J Membrane Biol 2010; 236: 137–46HjoujMRubinskyBMagnetic resonance imaging characteristics of non-thermal irreversible electroporation in vegetable tissueJ Membrane Biol20102361374610.1007/s00232-010-9281-220631997Search in Google Scholar
Ivorra A, Mir LM, Rubinsky B. Electric field redistribution due to conductivity changes during tissue electroporation: Experiments with a Simple Vegetal Model. In: Dössel O, Schlegel W, editors. World Congress on Medical Physics and Biomedical Engineering, September 7–12, 2009, Munich, Germany. Vol 25/13. IFMBE Proceedings. Berlin Heidelberg: Springer; 2010. p. 59–62 Available at http://dx.doi.org/10.1007/978-3-642-03895-2_18.IvorraAMirLMRubinskyBElectric field redistribution due to conductivity changes during tissue electroporation: Experiments with a Simple Vegetal ModelDösselOSchlegelWeditorsWorld Congress on Medical Physics and Biomedical Engineering September 7–122009Munich, GermanyVol 25/13IFMBE Proceedings. Berlin Heidelberg: Springer; 2010. p.5962Available athttp://dx.doi.org/10.1007/978-3-642-03895-2_1810.1007/978-3-642-03895-2_18Search in Google Scholar
Corovic S, Lackovic I, Sustaric P, Sustar T, Rodic T, Miklavcic D. Modeling of electric field distribution in tissues during electroporation. Biomed Eng Online 2013; 12: 16.CorovicSLackovicISustaricPSustarTRodicTMiklavcicDModeling of electric field distribution in tissues during electroporationBiomed Eng Online2013121610.1186/1475-925X-12-16361445223433433Search in Google Scholar
Miklavcic D, Snoj M, Zupanic A, Kos B, Cemazar M, Kropivnik M, et al. Towards treatment planning and treatment of deep-seated solid tumors by electrochemotherapy. Biomed Eng Online 2010; 9: 10.MiklavcicDSnojMZupanicAKosBCemazarMKropivnikMTowards treatment planning and treatment of deep-seated solid tumors by electrochemotherapyBiomed Eng Online201091010.1186/1475-925X-9-10284368420178589Search in Google Scholar
Pavselj N, Miklavcic D. Numerical models of skin electropermeabilization taking into account conductivity changes and the presence of local transport regions. Plasma Science, IEEE Transactions on 2008; 36: 1650–8PavseljNMiklavcicDNumerical models of skin electropermeabilization taking into account conductivity changes and the presence of local transport regionsPlasma Science, IEEE Transactions on2008361650810.1109/TPS.2008.928715Search in Google Scholar
Corovic S, Zupanic A, Miklavcic D. Numerical modeling and optimization of electric field distribution in subcutaneous tumor treated with electrochemotherapy using needle electrodes. Plasma Science, IEEE Transactions on 2008; 36: 1665–72CorovicSZupanicAMiklavcicDNumerical modeling and optimization of electric field distribution in subcutaneous tumor treated with electrochemotherapy using needle electrodesPlasma Science, IEEE Transactions on20083616657210.1109/TPS.2008.2000996Search in Google Scholar
Suárez C, Soba A, Maglietti F, Olaiz N, Marshall G. The role of additional pulses in electropermeabilization protocols. PLoS ONE 2014; 9: e113413.SuárezCSobaAMagliettiFOlaizNMarshallGThe role of additional pulses in electropermeabilization protocolsPLoS ONE20149e11341310.1371/journal.pone.0113413424991125437512Search in Google Scholar
Castellví Q, Banús J, Ivorra A. 3D Assessment of Irreversible Electroporation Treatments in Vegetal Models. In: Jarm T, Kramar P, eds. 1st World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food & Environmental Technologies. Vol 53. Singapore: Springer; 2016. p. 294–7CastellvíQBanúsJIvorraA3D Assessment of Irreversible Electroporation Treatments in Vegetal ModelsJarmTKramarPeds1st World Congress on Electroporation and Pulsed Electric Fields in Biology Medicine and Food & Environmental TechnologiesVol 53SingaporeSpringer2016294710.1007/978-981-287-817-5_65Search in Google Scholar
Ivorra A, Villemejane J, Mir LM. Electrical modeling of the influence of medium conductivity on electroporation. Phys Chem Chem Phys 2010; 12: 1055–64IvorraAVillemejaneJMirLMElectrical modeling of the influence of medium conductivity on electroporationPhys Chem Chem Phys201012100556410.1039/c004419a20585676Search in Google Scholar
Whelan MC, Larkin JO, Collins CG, Cashman J, Breathnach O, Soden DM, et al. Effective treatment of an extensive recurrent breast cancer which was refractory to multimodal therapy by multiple applications of electrochemotherapy. Eur J Cancer Suppl 2006; 4: 32–4WhelanMCLarkinJOCollinsCGCashmanJBreathnachOSodenDMEffective treatment of an extensive recurrent breast cancer which was refractory to multimodal therapy by multiple applications of electrochemotherapyEur J Cancer Suppl2006432410.1016/j.ejcsup.2006.07.006Search in Google Scholar
F. Dughiero, E. Sieni, C. R. Rossi, L. G. Campana, Patent No. VR2013A00184 “APPLICATORE PER ELETTROPORAZIONE”, 01/08/2013.F.DughieroSieniE.C. R.RossiL. G.CampanaPatent No. VR2013A000184 “APPLICATORE PER ELETTROPORAZIONE”01/08/2013Search in Google Scholar
