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A prototype of a flexible grid electrode to treat widespread superficial tumors by means of Electrochemotherapy

Luca G. Campana

Luca G. Campana

  • Surgical Oncology Unit, Veneto Institute of Oncology IOV-IRCCSPadova, Italy
  • Department of Surgery Oncology and Gastroenterology, University of PadovaPadova, Italy
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Campana, Luca G.
, 
Fabrizio Dughiero

Fabrizio Dughiero

Department of Industrial Engineering, University of PadovaPadova, Italy
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Dughiero, Fabrizio
, 
Michele Forzan

Michele Forzan

Department of Industrial Engineering, University of PadovaPadova, Italy
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Forzan, Michele
, 
Carlo R. Rossi

Carlo R. Rossi

  • Surgical Oncology Unit, Veneto Institute of Oncology IOV-IRCCSPadova, Italy
  • Department of Surgery Oncology and Gastroenterology, University of PadovaPadova, Italy
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Rossi, Carlo R.
 and 
Elisabetta Sieni

Elisabetta Sieni

Department of Industrial Engineering, University of PadovaPadova, Italy
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Sieni, Elisabetta
  
Feb 16, 2016
A prototype of a flexible grid electrode to treat widespread superficial tumors by means of Electrochemotherapy's Cover Image
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Article Category: Research Article
Published Online: Feb 16, 2016
Page range: 49 - 57
Received: Nov 03, 2015
Accepted: Jan 20, 2016
DOI: https://doi.org/10.1515/raon-2016-0013
Keywords
© 2016 Radiol Oncol
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Figure 1.

Chest wall recurrence from breast cancer and development of the grid electrode. (A) An example of a breast cancer patients who underwent repetitive ECT cycles to treat cutaneous metastases. The extension of electrode-induced skin marks highlights the extension of the treatment field and the need for more effective pulse delivery. (B) Sketch of the device, (C) resulting electric field lines of a grid electrode and (D) electric field color map.
Chest wall recurrence from breast cancer and development of the grid electrode. (A) An example of a breast cancer patients who underwent repetitive ECT cycles to treat cutaneous metastases. The extension of electrode-induced skin marks highlights the extension of the treatment field and the need for more effective pulse delivery. (B) Sketch of the device, (C) resulting electric field lines of a grid electrode and (D) electric field color map.

Figure 2.

Prototypes of the flexible electrode: (A) device with diameter 8 cm with hexagonal electrode disposition, (B) removable needles inserted in electrical connection and (C) square device 15 × 15 cm with hexagonal arrangement of conductive guides highlighted.
Prototypes of the flexible electrode: (A) device with diameter 8 cm with hexagonal electrode disposition, (B) removable needles inserted in electrical connection and (C) square device 15 × 15 cm with hexagonal arrangement of conductive guides highlighted.

Figure 3.

(A) Connection box to interface the flexible electrode to the voltage pulse generator. (B) Schema of the arrangement of clamps and (C) examples of connections.
(A) Connection box to interface the flexible electrode to the voltage pulse generator. (B) Schema of the arrangement of clamps and (C) examples of connections.

Figure 4.

Potato tuber after 24 h preserved at room temperature: (A) no voltage pulses (control) and (B) treated with voltage pulses.
Potato tuber after 24 h preserved at room temperature: (A) no voltage pulses (control) and (B) treated with voltage pulses.

Figure 5.

(A) Phantom used to test the square flexible electrode with side 15 cm. (B) Manual insertion of needles, (C) device ready for pulse application and (D) connection of the electrode with the connection box.
(A) Phantom used to test the square flexible electrode with side 15 cm. (B) Manual insertion of needles, (C) device ready for pulse application and (D) connection of the electrode with the connection box.

Figure 6.

(A) Potato tuber surface appears dark after 24 h from voltage pulse application and (B) effect of voltage pulses inside the potato.
(A) Potato tuber surface appears dark after 24 h from voltage pulse application and (B) effect of voltage pulses inside the potato.

Figure 7.

(A) Potato phantom surface appears dark after 24 h from voltage pulse application and (B) effect of voltage pulses inside the potato.
(A) Potato phantom surface appears dark after 24 h from voltage pulse application and (B) effect of voltage pulses inside the potato.

Example of supply needle pair sequence

#STEPNeedle pair#STEPNeedle pair
#11–2#14A–3
#21–3#15A–4
#31–4#16A–5
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