1. bookVolume 60 (2016): Issue 1 (March 2016)
Journal Details
License
Format
Journal
eISSN
2453-7837
First Published
30 Mar 2016
Publication timeframe
4 times per year
Languages
English
access type Open Access

Basic Roles of Sex Steroid Hormones in Wound Repair with Focus on Estrogens (A Review)

Published Online: 20 Apr 2016
Volume & Issue: Volume 60 (2016) - Issue 1 (March 2016)
Page range: 41 - 46
Received: 23 Nov 2015
Journal Details
License
Format
Journal
eISSN
2453-7837
First Published
30 Mar 2016
Publication timeframe
4 times per year
Languages
English
Abstract

Previously, it has been shown that sex hormones, in particular estrogens, play an important role in the regulation of biological processes involved in tissue repair and regeneration. Accordingly, several studies have supported the beneficial properties of hormone replacement therapies (HRT) in postmenopausal models. The present review paper explores the potential for targeted sex steroid HRT as a new therapeutic option for the surgical management of wounds in postmenopausal women and animals.

Keywords

1. Anaya, D. A., Dellinger, E. P., 2006: The obese surgical patient: a susceptible host for infection. Surg. Infect. (Larchmt), 7, 473-480.10.1089/sur.2006.7.47317083313Search in Google Scholar

2. Anderson, G. L., Limacher, M., Assaf, A. R., Bassford, T., Beresford, S. A., Black H. et al., 2004: Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women’s Health Initiative randomized controlled trial. JAMA, 291, 1701-1712.10.1001/jama.291.14.170115082697Search in Google Scholar

3. Angele, M. K., Catania, R. A., Ayala, A., Cioffi, W. G., Bland, K. I., Chaudry, I. H., 1998: Dehydroepiandrosterone: An inexpensive steroid hormone that decreases the mortality due to sepsis following trauma-induced haemorrhage. Arch. Surg., 133, 1281-1288.10.1001/archsurg.133.12.12819865644Search in Google Scholar

4. Araneo, B. A., Ryu, S. Y., Barton, S., Daynes, R. A., 1995: Dehydroepiandrosterone reduces progressive dermal ischemia caused by thermal injury. J. Surg. Res., 59, 250-262.10.1006/jsre.1995.11627637341Search in Google Scholar

5. Arvat, E., Di Vito, L., Lanfranco, F., Maccario, M., Baffoni, C., Rossetto, R. et al., 2000: Stimulatory effect of adrenocorticotropin on cortisol, aldosterone, and dehydroepiandrosterone secretion in normal humans: dose-response study. J. Clin. Endocrinol. Metab., 85, 3141-3146.10.1210/jcem.85.9.678410999799Search in Google Scholar

6. Ashcroft, G. S., Dodsworth, J., van Boxtel, E., Tarnuzzer, R. W., Horan, M. A., Schultz, G. S. et al., 1997: Estrogen accelerates cutaneous wound healing associated with an increase in TGF-β1 levels. Nat. Med. 3, 1209-1215.10.1038/nm1197-12099359694Search in Google Scholar

7. Ashcroft, G. S., Mills, S. J. 2002: Androgen receptor mediated inhibition of cutaneous wound healing. J. Clin. Invest., 110, 615-624.Search in Google Scholar

8. Ashcroft, G. S., Mills, S. J., Lei, K., Gibbons, L., Jeong, M. J., Taniguchi, M. et al., 2003: Estrogen modulates cutaneous wound healing by downregulating macrophage migration inhibitory factor. J. Clin. Invest., 111, 1309-1318.10.1172/JCI1628815444012727922Search in Google Scholar

9. Ashworth, J. J., Smyth, J. V., Pendleton, N., Horan, M., Payton, A., Worthington, J. et al., 2005: The dinucleotide (CA) repeat polymorphism of estrogen receptor beta but not the dinucleotide (TA) repeat polymorphism of estrogen receptor alpha is associated with venous ulceration. J. Steroid Biochem. Mol. Biol., 97, 266-270.10.1016/j.jsbmb.2005.05.01216153823Search in Google Scholar

10. Emmerson, E., Campbell, L., Ashcroft, G. S., Hardman, M. J., 2010: The phytoestrogen genistein promotes wound healing by multiple independent mechanisms. Mol. Cell Endocrinol., 321, 184-193.10.1016/j.mce.2010.02.02620193736Search in Google Scholar

11. Gantwerker, E. A., Hom, D. B., 2011: Skin: histology and physiology of wound healing. Facial Plast. Surg. Clin. North Am., 19, 441-453.10.1016/j.fsc.2011.06.00921856533Search in Google Scholar

12. Gilliver, S. C., Ashworth, J. J., Mills, S. J., Hardman, M. J., Ashcroft, G. S., 2006: Androgens modulate the inflammatory response during acute wound healing. J. Cell Sci. 119, Pt 4, 722-732.10.1242/jcs.02786Search in Google Scholar

13. Gilliver, S. C., Emmerson, E., Campbel, L., Chambon, P., Hardman, M. J., Ashcroft, S. G., 2010: 17β-estradiol inhibits wound healing in male mice via estrogen receptor-α. Am. J. Pathol., 176, 2707-2721.10.2353/ajpath.2010.090432Search in Google Scholar

14. Gosain, A., DiPietro, L. A., 2004: Aging and wound healing. World J. Surg., 28, 321-326.10.1007/s00268-003-7397-6Search in Google Scholar

15. Guo, S., DiPietro, L. A., 2010: Factors affecting wound healing. J. Dent. Res., 89, 219-229.10.1177/0022034509359125Search in Google Scholar

16. Hardman, M. J., Ashcroft, G. S., 2008: Estrogen, not intrinsic aging, is the major regulator of delayed human wound healing in the elderly. Genome Biol., 9, 1-17. doi:10.1186/gb-2008-9-5-r80, http://genomebiology.com/2008/9/5/R80.10.1186/gb-2008-9-5-r80Search in Google Scholar

17. Hardman, M. J., Emmerson, E., Campbell, L., Ashcroft, G. S., 2008: Selective estrogen receptor modulators accelerate cutaneous wound healing in ovariectomized female mice. Endocrinology, 149, 551-557.10.1210/en.2007-1042Search in Google Scholar

18. Holcomb, V. B., Keck, V. A., Barret, J. C., Hong, J., Libtti, S. K., Nunez, N. P., 2009: Obesity impairs wound healing in ovariectomized female mice. In vivo, 23, 515-518.Search in Google Scholar

19. Labrie, F., Belanger, A., Cusan, L., Gomez, J. L., Candas, B., 1997: Marked decline in serum concentrations of adrenal c19 sex steroid precursors and conjugated androgen metabolites during aging. J. Clin. Endocrinol. Metab., 82, 2396-2402.10.1210/jcem.82.8.4160Search in Google Scholar

20. Labrie, F., Belanger, A., Luu-The, V., Labrie, C., Simard, J., Cusan, L. et al., 1998: DHEA and the intracrine formation of androgens and estrogens in peripheral target tissues: Its role during aging. Steroids, 63, 322-328.10.1016/S0039-128X(98)00007-5Search in Google Scholar

21. Labrie, F., Luu-The, V., Lin, S. X., Simard, J., Labrie, C., El-Alfy, M. et al., 2000: Intracrinology: role of the family of 17-β hydroxysteroid dehydrogenases in human physiology and disease. Journal of Molecular Endocrinology, 25, 1-16.10.1677/jme.0.025000110915214Search in Google Scholar

22. Lemieux, C., Picard, F., Labrie, F., Richard, D., Deshaies, Y., 2003: The estrogen antagonist EM-652 and dehydroepiandrosterone prevent diet- and ovariectomy-induced obesity. Obes. Res. 11, 477-490.10.1038/oby.2003.6512634448Search in Google Scholar

23. Li, J., Chen, J., Kirsner, R., 2007: Pathophysiology of acute wound healing. Clinics in Dermatology, 25, 9-18.10.1016/j.clindermatol.2006.09.007Search in Google Scholar

24. Margolis, D. J., Knauss, J., Bilker, W., 2002: Hormone replacement therapy and prevention of pressure ulcers and venous leg ulcers. Lancet, 359, 675- 677.10.1016/S0140-6736(02)07806-6Search in Google Scholar

25. Mathieu, D., Linke, J. C., Wattel, F., 2006: Non-healing wounds. In Mathieu, D. E. (Ed.): Handbook on Hyperbaric Medicine, Netherlands: Springer, 401-427.10.1007/1-4020-4448-8_20Search in Google Scholar

26. Mills, S. J., Ashworth, J. J., Gilliver, S. C., Hardman, M. J., Aschcroft, G. S., 2005: The sex steroid precursor DHEA accelerates cutaneous wound healing via the estrogen receptors. J. Invest. Dermatol., 125, 1053-1062.10.1111/j.0022-202X.2005.23926.xSearch in Google Scholar

27. Pavletic, M. M., 2010: Basic principles of wound healing. In Atlas of Small Animal Wound Management and Reconstructive Surgery, 3rd edn., Wiley-Blackwell, 17-29.Search in Google Scholar

28. Pelletier, G., Ren, L., 2004: Localization of sex steroid receptors in human skin. Histol. Histopathol., 19, 629-636.Search in Google Scholar

29. Pospíšilová, A., 2011: New views on healing and treatment of wounds (In Czech). Practicus, 10, 27-30.Search in Google Scholar

30. Prentice, R. L., Manson, J. E., Langer, R. D., Anderson, G. L., Pettinger, M., Jackson, R. D. et al., 2009: Benefits and risks of postmenopausal hormone therapy when it is initiated soon after menopause. Am. J. Epidemiol., 170, 12-23.10.1093/aje/kwp115Search in Google Scholar

31. Punjabi, U., Deslypere, J. P., Verdonck,. L, Vermeulen, A., 1983: Androgen and precursor levels in serum and testes of adult rats under basal conditions and after HCG stimulation. J. Steroid Biochem., 19, 1481-1490.10.1016/0022-4731(83)91124-XSearch in Google Scholar

32. Rajabi, M. A., Rajabi, F., 2007: The effect of estrogen on wound healing in rats: 2007. Pak. J. Med. Sci., 23, 349-352.Search in Google Scholar

33. Robson, M. C., Steed, D. L., Franz, M. G., 2001: Wound healing: biologic features and approaches to maximize healing trajectories. Curr. Probl. Surg., 38, 72-140.10.1067/msg.2001.11116711452260Search in Google Scholar

34. Velnar, T., Bailey, T., Smrkoj, V., 2009: The wound healing process: an overview of the cellular and molecular mechanism. Journal of International Medical Research, 37, 1528-1542.10.1177/14732300090370053119930861Search in Google Scholar

35. Wang, S. B., Hu, K. M., Seamon, K. J., Mani, V., Chen, Y., Gronert, K., 2012: Estrogen negatively regulates epithelial wound healing and protective lipid mediator circuits in the cornea. The FASEB Journal, 26, 1506-1516.10.1096/fj.11-198036331690822186873Search in Google Scholar

36. Wu, J., Wang, X., Chiba, H., Higuchi, M., Nakatani, T., Ezaki, O. et al., 2004: Combined intervention of soy isoflavone and moderate exercise prevents body fat elevation and bone loss in ovariectomized mice. Metabolism, 53, 942-948.10.1016/j.metabol.2004.01.01915254891Search in Google Scholar

Recommended articles from Trend MD

Plan your remote conference with Sciendo