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Analysis of the mitochondrial 4977 bp deletion in patients with hepatocellular carcinoma

ZS Guo

ZS Guo

Department of Hepatobiliary Surgery, Zhuji People’s HospitalShaoxing, People’s Republic of China
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Guo, ZS
, 
CL Jin

CL Jin

Department of Endocrinology, Zhuji People’s HospitalShaoxing, People’s Republic of China
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Jin, CL
, 
ZJ Yao

ZJ Yao

Department of Hepatobiliary Surgery, Zhuji People’s HospitalShaoxing, People’s Republic of China
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Yao, ZJ
, 
YM Wang

YM Wang

Department of Hepatobiliary Surgery, Zhuji People’s HospitalShaoxing, People’s Republic of China
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Wang, YM
 and 
BT Xu

BT Xu

Department of Cardiothoracic Surgery, Zhuji People’s HospitalShaoxing, People’s Republic of China
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Xu, BT
  
Jun 30, 2017
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Article Category: Original Article
Published Online: Jun 30, 2017
Page range: 81 - 86
DOI: https://doi.org/10.1515/bjmg-2017-0006
Keywords
© 2017 Guo ZS, Jin CL, Yao ZJ, Wang YM, Xu BT
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Figure 1

Identification of the mtDNA 4977 bp deletion. M: DL2000 Marker; lane 1: control subjects without the 4977 bp deletion; lanes 2 and 3: patients with the mtDNA 4977 bp deletion.
Identification of the mtDNA 4977 bp deletion. M: DL2000 Marker; lane 1: control subjects without the 4977 bp deletion; lanes 2 and 3: patients with the mtDNA 4977 bp deletion.

Figure 2

Comparison of mtDNA content between HCC patients with the mtDNA 4977 bp deletion and control subjects.
Comparison of mtDNA content between HCC patients with the mtDNA 4977 bp deletion and control subjects.

Figure 3

Reactive oxygen species concentrations in HCC patients carrying the mtDNA 4977 bp deletion and control subjects.
Reactive oxygen species concentrations in HCC patients carrying the mtDNA 4977 bp deletion and control subjects.

Characterization of patients with hepatocellular carcinoma_

Parameters Number of HCC Patients mtDNA 4977 bp Deletion Frequency n (%)
Cases 104 10 (9.52)
Males 65 6 (5.71)
Females 40 4 (3.81)
Age ≥ 55 75 7 (6.67)
Age <55 30 3 (2.85)
History of alcohol consumption:
     yes 85 10 (9.52)
     no 20 0 (0.00)
Metastasis:
     positive 35 4 (3.81)
     negative 70 6 (5.71)
Language:
English
Publication timeframe:
2 times per year
Journal Subjects:
Medicine, Basic Medical Science, Basic Medical Science, other
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