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Analysis of the mitochondrial 4977 bp deletion in patients with hepatocellular carcinoma

ZS Guo

ZS Guo

Department of Hepatobiliary Surgery, Zhuji People’s HospitalShaoxing, People’s Republic of China
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Guo, ZS
, 
CL Jin

CL Jin

Department of Endocrinology, Zhuji People’s HospitalShaoxing, People’s Republic of China
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Jin, CL
, 
ZJ Yao

ZJ Yao

Department of Hepatobiliary Surgery, Zhuji People’s HospitalShaoxing, People’s Republic of China
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Yao, ZJ
, 
YM Wang

YM Wang

Department of Hepatobiliary Surgery, Zhuji People’s HospitalShaoxing, People’s Republic of China
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Wang, YM
 y 
BT Xu

BT Xu

Department of Cardiothoracic Surgery, Zhuji People’s HospitalShaoxing, People’s Republic of China
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Xu, BT
  
30 jun 2017
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Categoría del artículo: Original Article
Publicado en línea: 30 jun 2017
Páginas: 81 - 86
DOI: https://doi.org/10.1515/bjmg-2017-0006
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© 2017 Guo ZS, Jin CL, Yao ZJ, Wang YM, Xu BT
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Figure 1

Identification of the mtDNA 4977 bp deletion. M: DL2000 Marker; lane 1: control subjects without the 4977 bp deletion; lanes 2 and 3: patients with the mtDNA 4977 bp deletion.
Identification of the mtDNA 4977 bp deletion. M: DL2000 Marker; lane 1: control subjects without the 4977 bp deletion; lanes 2 and 3: patients with the mtDNA 4977 bp deletion.

Figure 2

Comparison of mtDNA content between HCC patients with the mtDNA 4977 bp deletion and control subjects.
Comparison of mtDNA content between HCC patients with the mtDNA 4977 bp deletion and control subjects.

Figure 3

Reactive oxygen species concentrations in HCC patients carrying the mtDNA 4977 bp deletion and control subjects.
Reactive oxygen species concentrations in HCC patients carrying the mtDNA 4977 bp deletion and control subjects.

Characterization of patients with hepatocellular carcinoma_

Parameters Number of HCC Patients mtDNA 4977 bp Deletion Frequency n (%)
Cases 104 10 (9.52)
Males 65 6 (5.71)
Females 40 4 (3.81)
Age ≥ 55 75 7 (6.67)
Age <55 30 3 (2.85)
History of alcohol consumption:
     yes 85 10 (9.52)
     no 20 0 (0.00)
Metastasis:
     positive 35 4 (3.81)
     negative 70 6 (5.71)
Idioma:
Inglés
Calendario de la edición:
2 veces al año
Temas de la revista:
Medicina, Ciencias médicas básicas, Ciencias médicas básicas, otros
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