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Assessment of genotoxicity of vincristine, vinblastine and vinorelbine in human cultured lymphocytes: a comparative study

NM Mhaidat

NM Mhaidat

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Mhaidat, NM
, 
KH Alzoubi

KH Alzoubi

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Alzoubi, KH
, 
OF Khabour

OF Khabour

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Khabour, OF
, 
KZ Alawneh

KZ Alawneh

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Alawneh, KZ
, 
LA Raffee

LA Raffee

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Raffee, LA
, 
ES Alsatari

ES Alsatari

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Alsatari, ES
, 
EI Hussein

EI Hussein

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Hussein, EI
 and 
KE Bani-Hani

KE Bani-Hani

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Bani-Hani, KE
  
Aug 02, 2016
Assessment of genotoxicity of vincristine, vinblastine and vinorelbine in human cultured lymphocytes: a comparative study's Cover Image
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Article Category: Original Article
Published Online: Aug 02, 2016
Page range: 13 - 20
DOI: https://doi.org/10.1515/bjmg-2016-0002
Keywords
© 2016 Walter de Gruyter GmbH, Berlin/Boston
This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
The level of 8-OHdG values in controls, VCR, VBL and VRL groups; each at concentrations of 0.01 and 0.1 μg/mL. The levels of 8-OHdG in all drug-treated groups at concentrations of 0.01 and 0.1 μg/mL were higher than control group. The asterisks (*) indicate significant differences (p <0.05) from the control group. The hash (#) indicates significant difference from all other groups.
The level of 8-OHdG values in controls, VCR, VBL and VRL groups; each at concentrations of 0.01 and 0.1 μg/mL. The levels of 8-OHdG in all drug-treated groups at concentrations of 0.01 and 0.1 μg/mL were higher than control group. The asterisks (*) indicate significant differences (p <0.05) from the control group. The hash (#) indicates significant difference from all other groups.
The average of SCEs/cell in controls, VCR, VBL and VRL groups; each at concentrations of 0.01 and 0.1 μg/mL in cultured blood cells. Increases were detected among the groups. However, it did not reach significant levels (control vs. VCR group: p >0.05; control vs. VBL group: p >0.05, and control vs. VRL group: p >0.05).
The average of SCEs/cell in controls, VCR, VBL and VRL groups; each at concentrations of 0.01 and 0.1 μg/mL in cultured blood cells. Increases were detected among the groups. However, it did not reach significant levels (control vs. VCR group: p >0.05; control vs. VBL group: p >0.05, and control vs. VRL group: p >0.05).
The mitotic index in cultured cells treated with VCR, VBL and VRL; each at concentrations of 0.01 and 0.1 μg/mL. The value of the mitotic index was significantly higher (p <0.05) in lymphocytes treated with VCR, VBL and VRL; each at concentrations of 0.01 and 0.1 μg/mL.
The mitotic index in cultured cells treated with VCR, VBL and VRL; each at concentrations of 0.01 and 0.1 μg/mL. The value of the mitotic index was significantly higher (p <0.05) in lymphocytes treated with VCR, VBL and VRL; each at concentrations of 0.01 and 0.1 μg/mL.
Language:
English
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2 times per year
Journal Subjects:
Medicine, Basic Medical Science, Basic Medical Science, other
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