Login
Register
Reset Password
Publish & Distribute
Publishing Solutions
Distribution Solutions
Subjects
Architecture and Design
Arts
Business and Economics
Chemistry
Classical and Ancient Near Eastern Studies
Computer Sciences
Cultural Studies
Engineering
General Interest
Geosciences
History
Industrial Chemistry
Jewish Studies
Law
Library and Information Science, Book Studies
Life Sciences
Linguistics and Semiotics
Literary Studies
Materials Sciences
Mathematics
Medicine
Music
Pharmacy
Philosophy
Physics
Social Sciences
Sports and Recreation
Theology and Religion
Publications
Journals
Books
Proceedings
Publishers
Blog
Contact
Search
EUR
USD
GBP
English
English
Deutsch
Polski
Español
Français
Italiano
Cart
Home
Journals
Balkan Journal of Medical Genetics
Volume 19 (2016): Issue 1 (June 2016)
Open Access
Assessment of genotoxicity of vincristine, vinblastine and vinorelbine in human cultured lymphocytes: a comparative study
NM Mhaidat
NM Mhaidat
,
KH Alzoubi
KH Alzoubi
,
OF Khabour
OF Khabour
,
KZ Alawneh
KZ Alawneh
,
LA Raffee
LA Raffee
,
ES Alsatari
ES Alsatari
,
EI Hussein
EI Hussein
and
KE Bani-Hani
KE Bani-Hani
| Aug 02, 2016
Balkan Journal of Medical Genetics
Volume 19 (2016): Issue 1 (June 2016)
About this article
Previous Article
Next Article
Abstract
Article
Figures & Tables
References
Authors
Articles in this Issue
Preview
PDF
Cite
Share
Article Category:
Original Article
Published Online:
Aug 02, 2016
Page range:
13 - 20
DOI:
https://doi.org/10.1515/bjmg-2016-0002
Keywords
Chromosomal aberrations
,
Human blood lymphocyte
,
8-hydroxy-2-deoxy guanosine (8-OHdG)
,
Sister chromatid exchanges
,
Vincristine (VCR)
,
Vinblastine (VBL)
,
Vinorelbine (VRL)
© 2016 Walter de Gruyter GmbH, Berlin/Boston
This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
The level of 8-OHdG values in controls, VCR, VBL and VRL groups; each at concentrations of 0.01 and 0.1 μg/mL. The levels of 8-OHdG in all drug-treated groups at concentrations of 0.01 and 0.1 μg/mL were higher than control group. The asterisks (*) indicate significant differences (p <0.05) from the control group. The hash (#) indicates significant difference from all other groups.
The average of SCEs/cell in controls, VCR, VBL and VRL groups; each at concentrations of 0.01 and 0.1 μg/mL in cultured blood cells. Increases were detected among the groups. However, it did not reach significant levels (control vs. VCR group: p >0.05; control vs. VBL group: p >0.05, and control vs. VRL group: p >0.05).
The mitotic index in cultured cells treated with VCR, VBL and VRL; each at concentrations of 0.01 and 0.1 μg/mL. The value of the mitotic index was significantly higher (p <0.05) in lymphocytes treated with VCR, VBL and VRL; each at concentrations of 0.01 and 0.1 μg/mL.