Accesso libero

Assessment of genotoxicity of vincristine, vinblastine and vinorelbine in human cultured lymphocytes: a comparative study

NM Mhaidat

NM Mhaidat

Cerca questo autore su
Sciendo|Google Scholar
Mhaidat, NM
, 
KH Alzoubi

KH Alzoubi

Cerca questo autore su
Sciendo|Google Scholar
Alzoubi, KH
, 
OF Khabour

OF Khabour

Cerca questo autore su
Sciendo|Google Scholar
Khabour, OF
, 
KZ Alawneh

KZ Alawneh

Cerca questo autore su
Sciendo|Google Scholar
Alawneh, KZ
, 
LA Raffee

LA Raffee

Cerca questo autore su
Sciendo|Google Scholar
Raffee, LA
, 
ES Alsatari

ES Alsatari

Cerca questo autore su
Sciendo|Google Scholar
Alsatari, ES
, 
EI Hussein

EI Hussein

Cerca questo autore su
Sciendo|Google Scholar
Hussein, EI
 e 
KE Bani-Hani

KE Bani-Hani

Cerca questo autore su
Sciendo|Google Scholar
Bani-Hani, KE
  
02 ago 2016
Assessment of genotoxicity of vincristine, vinblastine and vinorelbine in human cultured lymphocytes: a comparative study's Cover Image
INFORMAZIONI SU QUESTO ARTICOLO
Articolo precedente
Articolo Successivo
Cita
Scarica la copertina
Categoria dell'articolo: Original Article
Pubblicato online: 02 ago 2016
Pagine: 13 - 20
DOI: https://doi.org/10.1515/bjmg-2016-0002
Parole chiave
© 2016 Walter de Gruyter GmbH, Berlin/Boston
This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
The level of 8-OHdG values in controls, VCR, VBL and VRL groups; each at concentrations of 0.01 and 0.1 μg/mL. The levels of 8-OHdG in all drug-treated groups at concentrations of 0.01 and 0.1 μg/mL were higher than control group. The asterisks (*) indicate significant differences (p <0.05) from the control group. The hash (#) indicates significant difference from all other groups.
The level of 8-OHdG values in controls, VCR, VBL and VRL groups; each at concentrations of 0.01 and 0.1 μg/mL. The levels of 8-OHdG in all drug-treated groups at concentrations of 0.01 and 0.1 μg/mL were higher than control group. The asterisks (*) indicate significant differences (p <0.05) from the control group. The hash (#) indicates significant difference from all other groups.
The average of SCEs/cell in controls, VCR, VBL and VRL groups; each at concentrations of 0.01 and 0.1 μg/mL in cultured blood cells. Increases were detected among the groups. However, it did not reach significant levels (control vs. VCR group: p >0.05; control vs. VBL group: p >0.05, and control vs. VRL group: p >0.05).
The average of SCEs/cell in controls, VCR, VBL and VRL groups; each at concentrations of 0.01 and 0.1 μg/mL in cultured blood cells. Increases were detected among the groups. However, it did not reach significant levels (control vs. VCR group: p >0.05; control vs. VBL group: p >0.05, and control vs. VRL group: p >0.05).
The mitotic index in cultured cells treated with VCR, VBL and VRL; each at concentrations of 0.01 and 0.1 μg/mL. The value of the mitotic index was significantly higher (p <0.05) in lymphocytes treated with VCR, VBL and VRL; each at concentrations of 0.01 and 0.1 μg/mL.
The mitotic index in cultured cells treated with VCR, VBL and VRL; each at concentrations of 0.01 and 0.1 μg/mL. The value of the mitotic index was significantly higher (p <0.05) in lymphocytes treated with VCR, VBL and VRL; each at concentrations of 0.01 and 0.1 μg/mL.
Lingua:
Inglese
Frequenza di pubblicazione:
2 volte all'anno
Argomenti della rivista:
Medicina, Scienze medicali di base, Scienze medicali di base, altro
Feed RSS della rivista