<abstract xmlns="http://www.w3.org/1999/xhtml"><p> We evaluated the effect of the antipsychotic olanzapine on electrical activity of rat hearts under conditions of ischemic- reperfusion injury. We focused on the prolongation of the corrected QT interval as a risk factor for the incidence of different types of dysrhythmias. Pretreatment with olanzapine showed prolongation of the corrected QT interval as well as increased incidence of dysrhythmias in following order: ventricular premature beats > bigeminies > trigeminies > salvos. We also observed an increase in the frequency of episodes of ventricular tachycardia of about 64% and the average duration of ventricular tachycardia was more than doubled under the conditions of the ischemic-reperfusion injury. </p></abstract>

We evaluated the effect of the antipsychotic olanzapine on electrical activity of rat hearts under conditions of ischemic- reperfusion injury. We focused on the prolongation of the corrected QT interval as a risk factor for the incidence of different types of dysrhythmias. Pretreatment with olanzapine showed prolongation of the corrected QT interval as well as increased incidence of dysrhythmias in following order: ventricular premature beats > bigeminies > trigeminies > salvos. We also observed an increase in the frequency of episodes of ventricular tachycardia of about 64% and the average duration of ventricular tachycardia was more than doubled under the conditions of the ischemic-reperfusion injury.

The incidence of dysrhythmias after administration of the antipsychotic olanzapine

Comenius University in Bratislava, Faculty of Pharmacy, Department of Pharmacology and Toxicology, Bratislava,

European Pharmaceutical Journal

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

We evaluated the effect of the antipsychotic olanzapine on electrical activity of rat hearts under conditions of ischemic- reperfusion injury. We focused on...

The incidence of dysrhythmias after administration of the antipsychotic olanzapine

Published Online: Nov 23, 2016

Page range: 9 - 11

Received: Jun 23, 2016

Accepted: Jul 13, 2016

DOI: https://doi.org/10.1515/afpuc-2016-0004

Keywords
olanzapine, heart, QTc interval, dysrhythmias

© by P. Gulač

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

The incidence of dysrhythmias after administration of the antipsychotic olanzapine

Published Online: Nov 23, 2016

Page range: 9 - 11

Received: Jun 23, 2016

Accepted: Jul 13, 2016

DOI: https://doi.org/10.1515/afpuc-2016-0004

Keywordsolanzapine, heart, QTc interval, dysrhythmias

© by P. Gulač

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
olanzapine, heart, QTc interval, dysrhythmias