<abstract xmlns="http://www.w3.org/1999/xhtml"><p> We evaluated the effect of the antipsychotic olanzapine on electrical activity of rat hearts under conditions of ischemic- reperfusion injury. We focused on the prolongation of the corrected QT interval as a risk factor for the incidence of different types of dysrhythmias. Pretreatment with olanzapine showed prolongation of the corrected QT interval as well as increased incidence of dysrhythmias in following order: ventricular premature beats > bigeminies > trigeminies > salvos. We also observed an increase in the frequency of episodes of ventricular tachycardia of about 64% and the average duration of ventricular tachycardia was more than doubled under the conditions of the ischemic-reperfusion injury. </p></abstract>

We evaluated the effect of the antipsychotic olanzapine on electrical activity of rat hearts under conditions of ischemic- reperfusion injury. We focused on the prolongation of the corrected QT interval as a risk factor for the incidence of different types of dysrhythmias. Pretreatment with olanzapine showed prolongation of the corrected QT interval as well as increased incidence of dysrhythmias in following order: ventricular premature beats > bigeminies > trigeminies > salvos. We also observed an increase in the frequency of episodes of ventricular tachycardia of about 64% and the average duration of ventricular tachycardia was more than doubled under the conditions of the ischemic-reperfusion injury.

The incidence of dysrhythmias after administration of the antipsychotic olanzapine

Comenius University in Bratislava, Faculty of Pharmacy, Department of Pharmacology and Toxicology, Bratislava,

European Pharmaceutical Journal

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

We evaluated the effect of the antipsychotic olanzapine on electrical activity of rat hearts under conditions of ischemic- reperfusion injury. We focused on...

The incidence of dysrhythmias after administration of the antipsychotic olanzapine

Publié en ligne: 23 nov. 2016

Pages: 9 - 11

Reçu: 23 juin 2016

Accepté: 13 juil. 2016

DOI: https://doi.org/10.1515/afpuc-2016-0004

Mots clés
olanzapine, heart, QTc interval, dysrhythmias

© by P. Gulač

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

The incidence of dysrhythmias after administration of the antipsychotic olanzapine

Publié en ligne: 23 nov. 2016

Pages: 9 - 11

Reçu: 23 juin 2016

Accepté: 13 juil. 2016

DOI: https://doi.org/10.1515/afpuc-2016-0004

Mots clésolanzapine, heart, QTc interval, dysrhythmias

© by P. Gulač

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Mots clés
olanzapine, heart, QTc interval, dysrhythmias