<abstract xmlns="http://www.w3.org/1999/xhtml"> Olfactory ensheathing cells (OECs) join olfactory axons in their entrance to the central nervous system, representing a unique population of glial cells with functions in olfactory neurogenesis, axonal growth and olfactory bulb formation. Olfactory ensheathing cells have a great potential to induce repair for neural injuries, in central nervous system and peripheral nervous system, existing numerous experimental and clinical studies lately, reporting beneficial effects in anatomical and functional recovery. Studies are also conducted in order to establish possible pro-regenerative effects of the OECs, their potential in tissue repair and ability to modulate the immune system. The aim of this paper was to review the properties of olfactory ensheathing cells and their potential therapeutic role in regenerative medicine.</abstract>

Department of Plastic and Reconstructive Surgery, Emergency Clinical Hospital, Bucharest, Romania

ENT&HNS Department, „Sfanta Maria“ Hospital, Bucharest, Romania

The role of olfactory ensheating cells in regenerative medicine: review of the literature

<abstract xmlns="http://www.w3.org/1999/xhtml"> Nasal polyposis represents a late stage of long-lasting inflammation of the sinonasal mucosa, characterized by increased inflammatory cells infiltration and anomalous tissue remodelling. A wide range of chemical mediators such as cytokines, chemokines, cell adhesion molecules are involved in the pathomechanism of nasal polyposis, but their significance has not been completely clarified. Eosinophils are the dominant inflammatory cell population in nasal polyposis and are thought to be the central effector cells responsible for the onset and maintenance of the inflammatory process. Persistent inflammation of the sinonasal mucosa can lead to structural changes, such as epithelial damage, thickened basement membrane, stromal edema, formation of pseudocysts. This review summarizes prior and current knowledge regarding the involvement of the inflammatory process in the pathogenesis of nasal polyposis.</abstract>

The role of inflammatory mediators in the pathogenesis of nasal polyposis: Literature review

<abstract xmlns="http://www.w3.org/1999/xhtml">BACKGROUND. The reconstructive surgery is a domain in continuous research for new techniques and alloplastic materials for replacement of complex defects. Different biomaterials are used in soft tissue reconstruction including polypropylene meshes covered with collagen, which have the best results in abdominal and pelvic surgery, but are not yet used in nasal surgery. MATERIAL AND METHODS. We analysed the studies from the literature regarding the different alloplastic implants used in nasal reconstruction surgery, their benefits and contraindications for nasal defects. RESULTS. The most used polymers are Silicone, Medpor®, Mersilene® and polypropylene. Silicone is no longer widely used in facial reconstructive surgery because of its many complications. Medpor® (high-density polyethylene) is used for reconstruction of the facial skeleton and for aesthetic contour enhancement, including nasal reconstruction. Mersilene® (polyethylene terephthalate) is used for dorsum nasal defect reconstruction. Gore-Tex® is used for soft-tissue augmentation in the nose and is not recommended as a structural graft. Polypropylene meshes (Marlex®) are widely used in abdominal and chest wall reconstructive surgeries, with few studies on using them in nasal cartilage reconstruction. CONCLUSION. Nasal reconstructive surgery is a difficult part of plastic surgery than can cause many problems to the surgeon, the need for soft tissue and cartilage reconstruction are difficult to solve in a repeatedly operated nose with few autogenous graft options and complex reconstructive surgeries, especially in posttraumatic defects and revision rhinoplasties. There are many alloplastic implants that can be used with excellent results.</abstract>

Polypropylene meshes and other alloplastic implants for soft tissue and cartilage nasal reconstructive surgery – a literature review

<abstract xmlns="http://www.w3.org/1999/xhtml">BACKGROUND. The ostiomeatal complex (OMC) is the anatomical region situated between the middle turbinate and the lateral nasal wall, at the level of the middle meatus. Common anatomical variations of OMC are concha bullosa, hypertrophy of the uncinate process and of the bulla ethmoidalis and Haller’s cell. Our study was aimed to investigate the prevalence of these conditions and their relations to different symptoms. MATERIAL AND METHODS. The study is a retrospective descriptive study based on 256 files of patients who were hospitalized and treated for OMC pathology in our clinic between January 2009 and January 2014. The data acquired were included into Excel Worksheets and statistically analyzed using GraphPad Software. RESULTS. The most common finding was concha bullosa (63.67%), followed by hypertrophy of the bulla ethmoidalis (10.93%) and of the uncinate process (10.15%). Haller’s cell was found in only 3% of cases. The most common symptom for all patients was nasal obstruction, followed by nasal discharge. The majority of symptoms improved after functional endoscopic sinus surgery for OMC drainage. CONCLUSION. OMC pathology is a frequent indication for functional endoscopic sinus surgery. The most common condition that determines blockage of OMC and need for surgical treatment is concha bullosa. The most common complaint of patients with OMC pathology is nasal obstruction.</abstract>

Prof. Dr. Dorin Hociota” Institute of Phono-Audiology and Functional ENT Surgery, Bucharest, Romania

Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania

Department of Anatomy, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania

Evaluation of ostiomeatal complex pathology related to endoscopic sinus surgery – a retrospective analysis

<abstract xmlns="http://www.w3.org/1999/xhtml">BACKGROUND. Chronic maxillary sinusitis is a frequently encountered pathology, resistant to treatment, which can cause significant economic losses. Considering these aspects, it is necessary to develop new methods of treatment. OBJECTIVE. The purpose of this study was to assess the therapeutic efficacy of the “Cahul” ozonated mineral water in the treatment of experimentally induced chronic rhinosinusitis and its action on the mucosa of the maxillary sinus. MATERIAL AND METHODS. The experimental study was conducted on a group of 14 chinchilla rabbits, aged between 8 and 12 months, weighing 2.5-3.0 kg, kept in vivarium conditions. In the first stage of the study, chronic rhinosinusitis was induced. 3 months after, maxillary antrostomy in the medial wall was performed on all animals included in the study; the intervention was performed under general anesthesia. The rabbits were divided into two groups. The rabbits enrolled in the study group underwent daily inhalations and maxillary sinus lavage with the “Cahul” ozonated mineral water. In the control group, inhalations and lavage were performed with 0.9% NaCl solution. Efficacy of the treatment was assessed observing the clinical character of the pathology. On days 2, 5 and 9 of the experiment, endoscopic and histological examinations were performed. RESULTS. On the ninth day of treatment, if in the study group the appearance of the sinus mucosa was almost normal, in the control group, the histological examination revealed: epithelial hyperplasia, cylindrical cell hyperplasia, thickening of the basement membrane and lymphocyte infiltration. Mucosal fragments harvested after 5 days revealed submucosal fibrosis, leukocyte infiltration in the control group being more pronounced than in the study group. CONCLUSION. Maxillary sinus lavage with the “Cahul” ozonated mineral water improves mucociliary clearance and stimulates regeneration of affected cells.</abstract>

“Cahul” ozonated mineral water in the treatment of experimentally induced chronic rhinosinusitis

<abstract xmlns="http://www.w3.org/1999/xhtml">BACKGROUND. The pneumatization pattern of the sphenoid sinus seems rather unpredictable, as resulted from previous studies. It is however extremely important for endoscopic approaches to target structures of the middle cranial fossa, such as the pituitary gland. MATERIAL AND METHODS. We aimed at documenting by Cone Beam Computed Tomography (CBCT) the possibilities of anatomic variation of the sphenoid sinus. 25 randomly selected patients were retrospectively analyzed. RESULTS. In 56%, the left and right sphenoidal sinuses were bilaterally symmetrical with respect to the sagittal pneumatization type: four patients had sellar types, one had presellar type and in nine cases the sphenoidal sinuses were reaching posteriorly to the sella turcica. Only in 8% of cases were found conchal types of pneumatization, but they were part of anatomical pictures including Onodi air cells. Such an Onodi cell presented a posterior (sphenoidal) recess reaching posteriorly and superiorly to the pterygopalatine fossa. The recesses of the sphenoid sinus were also documented: anterior or septal, ethmoidal, maxillary, clinoidal and lateral. In 32% was found a lateral recess only engaged between the vidian and maxillary nerve canals. CONCLUSION. It appears that CBCT is a reliable tool for accurate anatomic identification of the sphenoid sinus pneumatization pattern, on a case-by-case basis.</abstract>

Variations of sphenoid pneumatization: a CBCT study

<abstract xmlns="http://www.w3.org/1999/xhtml"> Chronic rhinosinusitis represents an inflammatory condition of the nose and paranasal sinuses, characterized by two or more symptoms. The diagnosis of acute rhinosinusitis is made, most often, clinically; however, in the case of chronic rhinosinusitis, imaging, bacteriological, as well as the histological investigation are necessary in order to establish the diagnosis and to exclude other diseases that have caused and/or are associated with rhinosinusitis. Different scores (clinical, imagistic) have been described over time, being considered as important factors in the therapeutic decision (surgical or conservative) in patients with chronic rhinosinusitis. The authors present their experience in using and relying on endoscopic and histological scores.</abstract>

Endoscopic and histological staging: Deciding factors in the treatment of chronic rhinosinusitis

AHEAD OF PRINT

Volume 14 (2024): Issue 54 (April 2024)

Volume 14 (2024): Issue 53 (March 2024)

Volume 13 (2023): Issue 52 (December 2023)

Volume 13 (2023): Issue 51 (July 2023)

Volume 13 (2023): Issue 50 (April 2023)

Volume 13 (2023): Issue 49 (March 2023)

Volume 12 (2022): Issue 48 (December 2022)

Volume 12 (2022): Issue 47 (July 2022)

Volume 12 (2022): Issue 46 (April 2022)

Volume 12 (2022): Issue 45 (March 2022)

Volume 11 (2021): Issue 44 (December 2021)

Volume 11 (2021): Issue 43 (September 2021)

Volume 11 (2021): Issue 42 (June 2021)

Volume 11 (2021): Issue 41 (March 2021)

Volume 10 (2020): Issue 40 (December 2020)

Volume 10 (2020): Issue 39 (September 2020)

Volume 10 (2020): Issue 38 (June 2020)

Volume 10 (2020): Issue 37 (March 2020)

Volume 9 (2019): Issue 36 (December 2019)

Volume 9 (2019): Issue 35 (September 2019)

Volume 9 (2019): Issue 34 (June 2019)

Volume 9 (2019): Issue 33 (March 2019)

Volume 8 (2018): Issue 32 (October 2018)

Volume 8 (2018): Issue 31 (September 2018)

Volume 8 (2018): Issue 30 (June 2018)

Volume 8 (2018): Issue 29 (March 2018)

Volume 7 (2017): Issue 28 (December 2017)

Volume 7 (2017): Issue 27 (September 2017)

Volume 7 (2017): Issue 26 (June 2017)

Volume 7 (2017): Issue 25 (March 2017)

Volume 6 (2016): Issue 24 (December 2016)

Volume 6 (2016): Issue 23 (September 2016)

Volume 6 (2016): Issue 22 (June 2016)

Volume 6 (2016): Issue 21 (March 2016)

Volume 5 (2015): Issue 20 (December 2015)

Volume 5 (2015): Issue 19 (September 2015)

Volume 5 (2015): Issue 18 (June 2015)

Volume 5 (2015): Issue 17 (March 2015)

Romanian Journal of Rhinology

Rhinology, as an important part of Otorhinolaryngology, addresses a very frequent and diverse pathology, with important interdisciplinary implications. In the last decades, this medical field was the beneficiary of new technical means for accurate and effective investigation, treatment and research. The needs of modern medicine - over-specialization, interdisciplinary approach and evidence-based medicine, lead to the situation that the international rhinologic societies are the most dynamic and appreciated.  The Romanian Journal of Rhinology is the official scientific publication of the Romanian Rhinologic Society, and it is trying to fill the existing gap in the Romanian ENT literature, promoting modern publishing and criteria according to the international standards. Romanian Journal of Rhinology appears quarterly with the purpose to publish original articles, original clinical reports, clinically relevant experimental studies and short communications presenting new results of general interest. Its aim is to concentrate and provide information concerning care, cure and prevention of different rhinologic disorders and borderline pathology. With a peer review by an important national and international editorial board, the journal provides clinical and clinically related information written by authors from all over the world.  Journal’s business model  Romanian Journal of Rhinology is an Open Access journal. The submission and publication of the articles are free of charge, in both print and electronic publication. The publisher covers all costs – editing, printing, copyediting, typesetting, long-term archiving, journal management.  Romanian Journal of Rhinology is the journal of the Romanian Rhinologic Society; thus, one of the financial sources for publication is represented by the Society from the manuscript fees.  Advertisements represent another important founding source. The decision regarding the type of advertisements, acceptance/rejections, the price offering is made by the Publishing/technical Editor, the Editorial Board having no decision power on this aspect. Advertorials and publicity about pharmacological devices, drugs, supplements related to rhinologic and otolaryngologic pathologies can be taken into consideration. In case of Advertorials, with an important scientific content, the medical data presented will have the approval of the Journal’s Editors.  There is also available the annual subscription for individuals and companies. The contact person is also the Publishing/technical Editor.  Publication schedule  The Romanian Journal of Rhinology is published quarterly:   January-March (publication month: February)  April-June (publication month: April)  July-September (publication month: July)  October-December (publication month: October)  Editorial process  The Romanian Journal of Rhinology uses a standard scheme for the evaluation process of the submitted articles. All manuscripts are strictly reviewed for originality, correctness, methodology, quality of the medical information, suitability for the journal’s medical field, ethical nature.  The Editors reserve the right to refuse any manuscript which does not correspond to the submission guidelines.  Peer-review is the system used to assess the quality of a manuscript before it is published. Independent researchers in the otorhinolaryngology area assess the submitted manuscripts for originality, validity, and significance to help editors determine whether the manuscript should be published in their journal.  After submission:   All manuscript are treated as confidential documents, all being assigned with a registration number (for example, RJR010121 (day of submission)(month of submission) (the last two numbers of the year of submission)). All communications between the editors, the author(s), the reviewers are made by using this identification number.  Technical review performed by the editor-in-chief, associated editors, members of the editorial board analyses – the importance of the subject, presentation clarity, relevance, plagiarism index. Submissions that fail to fulfil all requirements are rejected. This process last for a few days after submission.  Review process. The Romanian Journal of Rhinology has a double-blind reviewing process, in which the reviewers do not know the names of the authors, and the authors do not know who reviewed their manuscript. Therefore, the authors are required to submit a blind manuscript without the authors’ names and affiliations on the title page or in the text and a separate title page with the names of the authors, affiliations, and information about the corresponding author. After the initial assessment for, submissions are sent to at least two experts in the field who are asked to evaluate whether the manuscript is scientifically coherent, easy to read, useful in the field, and whether the manuscript should be accepted, rejected or revised. The review process will take approximately 2 weeks. After the review process is completed, the corresponding author will receive an e- mail about the evaluation results of the submitted manuscript: accepted, revision or rejection. If the e-mail contains suggestions and comments for revising the manuscript, the authors should make the changes and return to the editor within 2 weeks; if not, the manuscript is considered rejected. If the manuscript is accepted for publication by the reviewers, it is forwarded to the Editor-in-Chief. The final decisions are made by the Editor-in-Chief based on the recommendations of reviewers reports and the journal’s editors. Where necessary, they will consult with members of the Editorial Board. The Editor-in-Chief may advice the corresponding author to make necessary revisions in order to publish the article. The final form of the article will be sent to the main author for the last approval from his/her part (if there are minor changes these should be send in no more than 1 week).  The publication process after the article’s submission may take 45 days, average. All accepted articles are assigned with a DOI number.  The Romanian Journal of Rhinology follows the International Committee of Medical Journal Editors (ICMJE) Recommendations for the Conduct, Reporting, Editing and Publication of Scholarly Work in Medical Journals and required ICMJSE to be listed as a journal that follows these recommendations.  Archiving  Sciendo archives the contents of this journal in Portico - digital long-term preservation service of scholarly books, journals and collections.  Plagiarism Policy  The editorial board is participating in a growing community of Similarity Check System's users in order to ensure that the content published is original and trustworthy. Similarity Check is a medium that allows for comprehensive manuscripts screening, aimed to eliminate plagiarism and provide a high standard and quality peer-review process. 