<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Five of thiourea derivatives were prepared using as a starting compound 3-(trifluoromethyl)aniline, 4-chloro-3-nitroaniline, 1,3-thiazol- 2-amine, 2<italic>H</italic>-1,2,3-triazol-4-amine and commercial isothiocyanates. All compounds were evaluated <italic>in vitro</italic> for antimicrobial activity. Derivatives 2 and 3 showed the highest inhibition against Gram-positive cocci (standard and hospital strains). The observed MIC values were in the range of 0.5–8 μg/ml. The products effectively inhibited the formation of biofilms of methicillin-resistant and standard strains of <italic>Staphylococcus epidermidis</italic>. Inhibitory activity of thioureas 2 and 3 against <italic>Staphylococcus aureus</italic> topoisomerase IV was studied. The examined compounds were nongenotoxic.</p>
</abstract>

Five of thiourea derivatives were prepared using as a starting compound 3-(trifluoromethyl)aniline, 4-chloro-3-nitroaniline, 1,3-thiazol- 2-amine, 2H-1,2,3-triazol-4-amine and commercial isothiocyanates. All compounds were evaluated in vitro for antimicrobial activity. Derivatives 2 and 3 showed the highest inhibition against Gram-positive cocci (standard and hospital strains). The observed MIC values were in the range of 0.5–8 μg/ml. The products effectively inhibited the formation of biofilms of methicillin-resistant and standard strains of Staphylococcus epidermidis. Inhibitory activity of thioureas 2 and 3 against Staphylococcus aureus topoisomerase IV was studied. The examined compounds were nongenotoxic.

Antistaphylococcal Activity of Selected Thiourea Derivatives

Polish Journal of Microbiology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Antistaphylococcal Activity of Selected Thiourea Derivatives"}

Five of thiourea derivatives were prepared using as a starting compound 3-(trifluoromethyl)aniline, 4-chloro-3-nitroaniline, 1,3-thiazol- 2-amine,...

Antistaphylococcal Activity of Selected Thiourea Derivatives

Data publikacji: 28 lut 2016

Zakres stron: 451 - 460

Otrzymano: 20 sie 2015

Przyjęty: 08 mar 2016

DOI: https://doi.org/10.5604/17331331.1227671

Słowa kluczowe
antistaphylococcal activity, anti-biofilm activity, genotoxicity, thiourea derivatives

© 2016 JOANNA STEFAŃSKA et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Antistaphylococcal Activity of Selected Thiourea Derivatives

Data publikacji: 28 lut 2016

Zakres stron: 451 - 460

Otrzymano: 20 sie 2015

Przyjęty: 08 mar 2016

DOI: https://doi.org/10.5604/17331331.1227671

Słowa kluczoweantistaphylococcal activity, anti-biofilm activity, genotoxicity, thiourea derivatives

© 2016 JOANNA STEFAŃSKA et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Słowa kluczowe
antistaphylococcal activity, anti-biofilm activity, genotoxicity, thiourea derivatives