Age (y) | Paclitaxel cycle in | Premedication with | ||
---|---|---|---|---|
which HSR | dexamethasone | Signs and | Note** | |
(cycle) developed | (dose, mg) | symptoms of HSR | ||
33 | 1st | 10 mg | Flushing | After HSR in the 1st cycle, she received dexamethasone 10 mg premedication in all other cycles |
54 | 2nd | 0 mg | Sweating, abdominal and back pain | In the 1st cycle, she received 10 mg dexamethasone; it was withheld in the 2nd cycle |
43 | 4th | 0 mg | Flushing premedication | No history of dexamethasone |
49 | 8th | 0 mg | Back pain | No history of dexamethasone premedication in 1st, 2nd, 4th, 5th, 6th, and 7th cycles. However, she received dexamethasone 5 mg iv in the 3rd cycle |
56 | 4 th and 5th | 0 mg and 0 mg | Flushing | In the 1st cycle, received 10 mg dexamethasone; it was withheld in the 2nd, 3rd, 4th, and 5th cycles |
44 | 5 th and 6th | 10 mg and 20 mg | Flushing | Received dexamethasone premedication 10-20 mg iv in all cycles |
Baseline characteristic | Breast cancer patients (n = 86) |
---|---|
Age (y) (mean ± SD) | 52.6 ± 9.8 (range 33-78) |
Body weight (kg) (mean ± SD) | 58.8 ± 10.4 |
Body mass index (kg/m2) (mean ± SD) | 24.5 ± 4.2 |
Adjuvant/neoadjuvant chemotherapy regimen (number; %) | |
Paclitaxel | 61 (70%) |
Paclitaxel + Trastuzumab | 25 (30%) |
Received paclitaxel cycle (number; %) | |
12 cycles | 73 (85%) |
>6 cycles | 13 (15%) |
Menopausal status | |
Premenopausal | 21 (24%) |
Postmenopausal | 65 (76%) |
Underlying disease | |
No allergy/asthma | 83 (97%) |
Allergy/asthma | 3 (4%) |
Pathology (number; %) | |
Infiltrating ductal carcinoma | 81 (94%) |
Noninfiltrating ductal carcinoma | 4 (5%) |
Unknown | 1 (1%) |
Infiltrating ductal carcinoma grading (number; %) | |
Grade I | 3 (4%) |
Grade II | 48 (56%) |
Grade III | 29 (34%) |
Unknown | 6 (7%) |
Staging (number; %) | |
Stage I | 3 (4%) |
Stage II | 33 (38%) |
Stage III | 50 (58%) |
Physician preferences (number; %) | |
Medical oncology clinic | 72 (84%) |
Radiation oncology clinic | 13 (15%) |
Surgical oncology clinic | 1 (1%) |
Patient characteristic | Total (n = 86) | No HSR (n = 80) | HSR (n = 6) | |
---|---|---|---|---|
Age (y; mean) | 52.62 | 53 | 46.50 | 0.12 |
Body weight (kg; mean) | 58.77 | 59 | 55.97 | 0.49 |
Body mass index (kg/m2; mean) | 24.46 | 25 | 23.46 | 0.54 |
Body mass index | ||||
<25 (kg/m2; mean) | 53 | 49 (61%) | 4 (67%) | |
25-30 (kg/m2; mean) | 23 | 21 (26%) | 2 (33%) | 0.87 |
>30 (kg/m2; mean) | 10 | 10(13%) | 0 (0%) | >0.999 |
Menopausal status | 0.15 | |||
Premenopausal | 21 | 18 (22.5%) | 3 (50%) | |
Postmenopausal | 65 | 62 (77.5%) | 3 (50%) | |
Underlying disease | ||||
No allergy/asthma | 83 | 77 (96%) | 6 (100%) | |
Allergy/asthma | 3 | 3 (4%) | 0 (0%) | >0.999 |