HIV-infected children in the Asia-Pacific region with baseline severe anemia: antiretroviral therapy and outcomes
, , , , , , , , , , , , , , , , oraz | 31 sty 2017
O artykule
Article Category: Brief communication (Original)
Data publikacji: 31 sty 2017
Zakres stron: 229 - 234
DOI: https://doi.org/10.5372/1905-7415.1003.484
Słowa kluczowe
© 2016 Pagakrong Lumbiganon, Pope Kosalaraksa, Torsak Bunupuradah, David Boettiger, Vonthanak Saphonn, Khanh H. Truong, Nia Kurniati, Rawiwan Hansudewechakul, Viet C. Do, Tavitiya Sudjaritruk, Nagalingeswaran Kumarasamy, Nantakar Kongstan, Nik K. N. Yusoff, Lam V. Nguyen, Dewi K. Wati, Kamarul Razali, Annette H. Sohn, Azar Kariminia
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
Baseline characteristics of HIV-infected children with severe anemia
| Characteristics | Number (%) |
|---|---|
| <1 | 19 (14.6%) |
| 1 to 5 | 66 (50.8%) |
| 6 to 10 | 32 (24.6%) |
| >10 | 13 (10.0%) |
| Median (IQR) | 3.48 (1.67 to 6.32) |
| > –1.5 | 9 (7.9%) |
| –1.5 to –2.5 | 24 (21.1%) |
| < –2.5 | 81 (71.0%) |
| Median (IQR) | –-3.2 (–4.2 to –2.3) |
| > –1.5 | 9 (7.1%) |
| –1.5 to –2.5 | 13 (10.3%) |
| < –2.5 | 104 (82.5%) |
| Median (IQR) | –4.3 (–6.4 to –2.9) |
| >25 | 7 (6.0%) |
| 15 to 24 | 21 (18.1%) |
| 10 to 14 | 18 (15.5%) |
| <10 | 70 (60.4%) |
| Median (IQR) | 5.9 (1.0 to 13.9) |
| 1 or 2 | 24 (18.5%) |
| 3 | 63 (48.5%) |
| 4 | 43 (33.1%) |
| 2003 to 2005 | 40 (30.8%) |
| 2006 to 2008 | 49 (37.7%) |
| 2009 to 2013 | 41 (31.5%) |
Outcomes of children initiated on (a) AZT-containing regimens (n = 18) and (b) d4T-containing regimens (n = 111) over 36 months of follow-up
| Months of antiretroviral therapy | 0 | 6 | 12 | 18 | 24 | 30 | 36 |
|---|---|---|---|---|---|---|---|
| Cumulative AZT modifications | 0 | 2 | 3 | 3 | 3 | 3 | 3 |
| Deaths | 0 | 4 | 4 | 5 | 5 | 5 | 5 |
| Loss to follow-up 3.6 (95% CI 0.9–14.4) per 100 patient-years | 0 | 2 | 2 | 2 | 2 | 2 | 2 |
| Censored | 0 | 1 | 1 | 1 | 2 | 2 | 2 |
| Cumulative d4T modifications | 0 | 0 | 9 | 16 | 22 | 30 | 36 |
| Deaths | 0 | 7 | 10 | 12 | 13 | 13 | 13 |
| Loss to follow-up 2.6 (95% CI 1.5–4.4) per 100 patient-years | 0 | 1 | 3 | 3 | 4 | 5 | 6 |
| Censored | 0 | 1 | 1 | 6 | 8 | 9 | 10 |