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Observational study of omeprazole for gastroesophageal reflux on pulmonary function in adult asthmatics

Nattapong Jaimchariyatam
Nattapong Jaimchariyatam
, 
Phurin Haprasert
Phurin Haprasert
, 
Sutep Gonchanvit
Sutep Gonchanvit
 oraz 
Somkiat Wongtim
Somkiat Wongtim
   | 31 sty 2017
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Article Category: Original article
Data publikacji: 31 sty 2017
Zakres stron: 139 - 145
DOI: https://doi.org/10.5372/1905-7415.0902.379
Słowa kluczowe
© 2017 Nattapong Jaimchariyatam, Phurin Haprasert, Sutep Gonchanvit, Somkiat Wongtim
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Figure 1

Flow of the patients through the study
Flow of the patients through the study

Figure 2

Change in asthma control level after omeprazole treatment. Solid bars indicate partly controlled asthma after treatment, and open bars indicate controlled asthma after treatment.
Change in asthma control level after omeprazole treatment. Solid bars indicate partly controlled asthma after treatment, and open bars indicate controlled asthma after treatment.

Pulmonary function and ACT score after treatment 1 and 2 months

VariablesBaseline4th week8th week
FEV11.99 + 0 562.20 + 0 64

P < 0.001 vs. baseline,

2.36 + 0 58

P < 0.001 vs. baseline,

FVC2.84 + 0.743.05 + 0.81

P < 0.05 vs. baseline

3.13 + 0.82

P < 0.001 vs. baseline,

PEF338.64 + 109.60365.0 + 103.0

P < 0.05 vs. baseline

399.47 + 101.79

P < 0.001 vs. baseline,

ACT16.36 + 3.9720.82 + 3.30

P < 0.001 vs. baseline,

23.00 + 1.69

P < 0.001 vs. baseline,

Gender differences and the improvement of pulmonary function and ACT score after treatment

VariablesBaseline4th week8th week
FEV1 (L)
  Male2.20 + 0.482.46 + 0.50

P < 0.001 vs. baseline,

2.55 + 0.49

P < 0.001 vs. baseline,

  Female1.74 + 0.521.91 + 0.61

P < 0.05 vs. baseline

2.05 + 0.51

P < 0.05 vs. baseline

FVC (L)
  Male3.21 + 0.633.41 + 0.683.46 + 0.71

P < 0.05 vs. baseline

  Female2.43 + 0.562.68 + 0.70

P < 0.05 vs. baseline

2.75 + 0.60

P < 0.001 vs. baseline,

PEF (L/min)
  Male378.33 + 79.07403.33 + 78.89

P < 0.05 vs. baseline

430.83 + 68.02

P < 0.001 vs. baseline,

  Female295.83 + 114.85322.50 + 103.14

P < 0.05 vs. baseline

341.67 + 104.26

P < 0.001 vs. baseline,

ACT score
  Male17.08 + 3.2921.67 + 1.92

P < 0.001 vs. baseline,

23.42 + 1.31

P < 0.001 vs. baseline,

  Female15.50 + 4.6620.08 + 4.03

P < 0.001 vs. baseline,

22.83 + 1.85

P < 0.001 vs. baseline,

Baseline characteristics

CharacteristicValue (%)
Number of patients24
Male sex, no (%)12 (50)
Age, years
 mean ± SD51.92 ± 10.71
 range31-70
Male age, year53.17 ± 10.95
Female age, year50.67 ± 10.78
Body mass index, kg/m222.07 ± 4.79
Symptomatic GERD, no (%)18 (75)
 regurgitation18 (100)
 heartburn15 (83)
 chest pain13 (72)
 chronic cough10 (55)
 hoarseness8 (44)
Asthma control status, no (%)
 partly controlled18 (75)
 uncontrolled6 (25)
Medication, no (%)
 SABA+ICS7 (29)
 SABA+LABA/ICS12 (50)
 SABA+LABA/ICS+theophylline4 (17)
 SABA+LABA/ICS+theophylline+antileukotriene1 (4)
Coexisting conditions, no (%)
 allergic rhinitis8 (33)
 hypertension6 (25)
 avascular necrosis1 (4)
 diabetes mellitus3 (12)
 benign prostate hypertrophy1 (4)
 dyslipidemia3 (13)
ACT score, no (%)
 20-248 (33)
 <2016 (67)
Smoking status0 (0)
eISSN:
1875-855X
Język:
Angielski
Częstotliwość wydawania:
6 razy w roku
Dziedziny czasopisma:
Medicine, Assistive Professions, Nursing, Basic Medical Science, other, Clinical Medicine
Kanał RSS czasopisma