Otwarty dostęp

Epidemiology of upper gastrointestinal bleeding and Helicobacter pylori infection: review of 3,488 Thai patients

Sakolwan Suchartlikitwong
Sakolwan Suchartlikitwong
, 
Kamolyut Lapumnuaypol
Kamolyut Lapumnuaypol
, 
Rungsun Rerknimitr
Rungsun Rerknimitr
 oraz 
Duangporn Werawatganon
Duangporn Werawatganon
   | 31 sty 2017
Asian Biomedicine's Cover Image
O artykule
Poprzedni artykuł
Następny artykuł
Zacytuj
Article Category: Brief communication (Original)
Data publikacji: 31 sty 2017
Zakres stron: 87 - 93
DOI: https://doi.org/10.5372/1905-7415.0901.373
Słowa kluczowe
© 2017 Sakolwan Suchartlikitwong, Kamolyut Lapumnuaypol, Rungsun Rerknimitr, Duangporn Werawatganon
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Figure 1

Age and sex distribution of patients with “upper gastrointestinal bleeding” and “iron deficiency” after exclusion of data from patients less than 10 years old, those with successive endoscopic studies to follow up, incomplete study, uncertain diagnosis, and normal findings, with iron deficiency where the findings did not explain iron deficiency, or who needed lower gastro–enteroscopy. Furthermore, data from patients with diagnoses that were outside the upper gastrointestinal tract, such as jejunal ulcer and gastrojejunal ulcer were also excluded.
Age and sex distribution of patients with “upper gastrointestinal bleeding” and “iron deficiency” after exclusion of data from patients less than 10 years old, those with successive endoscopic studies to follow up, incomplete study, uncertain diagnosis, and normal findings, with iron deficiency where the findings did not explain iron deficiency, or who needed lower gastro–enteroscopy. Furthermore, data from patients with diagnoses that were outside the upper gastrointestinal tract, such as jejunal ulcer and gastrojejunal ulcer were also excluded.

Figure 2

Incidence of H. pylori infection in patients presenting with upper gastrointestinal bleeding *Data June–December in 2007
Incidence of H. pylori infection in patients presenting with upper gastrointestinal bleeding *Data June–December in 2007

Age-specific prevalence of H. pylori infection and causes of upper gastrointestinal bleeding

Age group(y)H. pylori positive no. of cases (%

Percentage of H. pylori positive or lesion positive comparing within each age groups

)		NUM no. of cases (%)GU no. of cases (%)DU no. of cases (%)esophageal-related cause no. of cases (%)Cirrhosis no. of cases (%)Malignancy no. of cases (%)Vascularno. of cases (%)
<4063 (43.8)95 (31.5)44 (14.6)58 (19.2)96 (31.8)49 (16.2)8 (2.6)2 (0.7)
40-59134 (31.4)276 (27.5)212 (21.2)128 (12.8)219 (21.9)209 (20.9)33 (3.3)17 (1.7)
60-79205 (23.7)512 (31.1)511 (31.1)203 (12.3)416 (25.3)128 (7.8)52 (3.2)38 (2.3)
>7960 (21.7)160 (29.7)169 (31.4)83 (15.4)179 (26.1)13 (2.4)10 (1.9)12 (2.2)
Total462 (27.0)1043 (29.9)936 (26.8)472 (13.5)910 (26.1)399 (11.4)103 (3.0)69 (2.0)
p

age-specific groups and H. pylori-positive or lesion-positive cases

<0.0010.242<0.0010.006<0.001<0.0010.3890.239

The 4,454 endoscopic findings, association with H. pylori and mean age

Endoscopic findingNumber (%)H. pylori positive cases/total

“Total” means numbers of patients who had the lesion and were on Campylobacter-like organism (CLO) test. “Case” means patients who had the lesion and were positive on CLO test.

(%)		Odds ratioP

bSignificant difference between H. pylori positive and negative group

Mean age ± SD (years)P

Significant difference between the mean age of a lesion and lesion-free on each endoscopic finding

Lesion positiveLesion negative
Gastric ulcer936 (21)150/589 (25.5)0.890.366.52 ± 13.962.12 ± 16.5<0.001
Duodenal ulcer472 (10.6)99/277 (35.7)1.62<0.00162.29 ± 17.763.46 ± 15.60.18
Concurrent gastroduodenal ulcer293 (6.6)71/194 (36.6)1.630.00167.15 ± 13.962.95 ± 16.1<0001
Non-ulcer-mucosal lesion1,043 (23.4)147/634 (23.2)0.730.00763.58 ± 16.163.18 ± 15.90.50
Esophageal-related cause910 (20.4)115/424 (27.1)1.000.9464.16 ± 17.363.00 ± 15.40.08
Cirrhosis399 (9)1/32 (3.1)0.080.00254.87 ± 13.564.39 ± 15.9<0.001
Concurrent peptic ulcer disease with cirrhosis192 (4.3)9/62 (14.5)0.450.02458.71 ± 13.463.57 ± 16.0<0.001
Malignancy103 (2.3)8/26 (30.8)1.190.6662.44 ± 14.363.33 ± 15.90.58
Vascular lesion69 (1.6)2/11 (18.2)0.590.5167.87 ± 13.463.21 ± 15.90.01
Miscellaneous37 (0.8)0/2 (0)0.000.3962.97 ± 18.963.30 ± 15.90.90

Type of malignancy that caused upper gastrointestinal bleeding with proved tissue-pathology

Type of cancerNumber of patients
Gastric cancer (adenocarcinoma)36
Gastric lymphoma15
Other cancers metastasis15
Esophageal cancer (squamous cell carcinoma)12
Gastrointestinal stromal tumor (GIST)11
Ampullary cancer (adenocarcinoma)4
Periampullary cancer3
Pancreatic cancer3
Duodenal cancer (adenocarcinoma)1
Pancreatic endocrine tumor1
Epiglottic cancer1
Pyriform sinus cancer1
eISSN:
1875-855X
Język:
Angielski
Częstotliwość wydawania:
6 razy w roku
Dziedziny czasopisma:
Medicine, Assistive Professions, Nursing, Basic Medical Science, other, Clinical Medicine
Kanał RSS czasopisma