Tissue Engineering Heart Valves – a Review of More than Two Decades into Preclinical and Clinical Testing for Obtaining the Next Generation of Heart Valve Substitutes
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Iung B, A Vahanian. Epidemiology of valvular heart disease in the adult. Nature Reviews Cardiology. 2011; 8(3): 162–72.IungBVahanianAEpidemiology of valvular heart disease in the adult2011831627210.1038/nrcardio.2010.20221263455Search in Google Scholar
Aikawa E, Schoen FJ. Calcific and Degenerative Heart Valve Disease. In Cellular and Molecular Pathobiology of Cardiovascular Disease. Ed: Willis MS, Homeister JW, Stone JR. Elsevier, London, 2014, 161–80.AikawaESchoenFJCalcific and Degenerative Heart Valve DiseaseInEd:WillisMSHomeisterJWStoneJRElsevierLondon20141618010.1016/B978-0-12-405206-2.00009-0Search in Google Scholar
Gillinov AM, Blackstone EH, Nowicki ER, et al. Valve repair versus valve replacement for degenerative mitral valve disease. Journal of Thoracic and Cardiovascular Surgery. 2008; 135:885–93.GillinovAMBlackstoneEHNowickiERValve repair versus valve replacement for degenerative mitral valve disease20081358859310.1016/j.jtcvs.2007.11.03918374775Search in Google Scholar
Daneshmand MA, Milano CA, Rankin JS, et al. Mitral valve repair for degenerative disease: a 20-year experience. Annals of Thoracic Surgery. 2009; 88:1828–37.DaneshmandMAMilanoCARankinJSMitral valve repair for degenerative disease: a 20-year experience20098818283710.1016/j.athoracsur.2009.08.00819932244Search in Google Scholar
Habib G, Thuny F, Avierinos JF. Prosthetic valve endocarditis: current approach and therapeutic options. Progress In Cardiovascular Diseases. 2008;50:274–81.HabibGThunyFAvierinosJFProsthetic valve endocarditis: current approach and therapeutic options2008502748110.1016/j.pcad.2007.10.00718156006Search in Google Scholar
Friedewald VE, Bonow RO, Borer JS, et al. The editor's roundtable: cardiac valve surgery. American Journal Of Cardiology. 2007; 99: 1269–78.FriedewaldVEBonowROBorerJSThe editor's roundtable: cardiac valve surgery20079912697810.1016/j.amjcard.2007.02.04017478156Search in Google Scholar
Chiang YP, Chikwe J, Moskowitz AJ, et al. Survival and long-term outcomes following bioprosthetic vs mechanical aortic valve replacement in patients aged 50 to 69 years. JAMA. 2014; 312:1323–9.ChiangYPChikweJMoskowitzAJSurvival and long-term outcomes following bioprosthetic vs mechanical aortic valve replacement in patients aged 50 to 69 years20143121323910.1001/jama.2014.1267925268439Search in Google Scholar
Zhu AS, Grande-Allen KJ. Heart valve tissue engineering for valve replacement and disease modeling. Current Opinion in Biomedical Engineering. 2018; 5:35–41.ZhuASGrande-AllenKJHeart valve tissue engineering for valve replacement and disease modeling20185354110.1016/j.cobme.2017.12.006Search in Google Scholar
Jacobs JP, Mavroudis C, Quintessenza JA, Chai, et al. Reoperations for pediatric and congenital heart disease: an analysis of the Society of Thoracic Surgeons (STS) congenital heart surgery database. In Seminars in Thoracic and Cardiovascular Surgery: Pediatric Cardiac Surgery Annual. 2014; 17(1): 2–8.JacobsJPMavroudisCQuintessenzaJAChaiReoperations for pediatric and congenital heart disease: an analysis of the Society of Thoracic Surgeons (STS) congenital heart surgery database20141712810.1053/j.pcsu.2014.01.006427614724725711Search in Google Scholar
Boroumand S, Asadpour S, Akbarzadeh A, et al. Heart valve tissue engineering: an overview of heart valve decellularization processes. Regenerative medicine. 2018; 13(1): 41–54.BoroumandSAsadpourSAkbarzadehAHeart valve tissue engineering: an overview of heart valve decellularization processes2018131415410.2217/rme-2017-006129360011Search in Google Scholar
Masoumi N, Jean A, Zugates JT, et al. Laser microfabricated poly(glycerol sebacate) scaffolds for heart valve tissue engineering. Journal Of Biomedical Materials Research Part A 2013; 101: 104–14.MasoumiNJeanAZugatesJTLaser microfabricated poly(glycerol sebacate) scaffolds for heart valve tissue engineering20131011041410.1109/NEBC.2011.5778693Search in Google Scholar
Fallahiarezoudar E, Ahmadipourroudposht M, Idris A, et al. A review of: application of synthetic scaffold in tissue engineering heart valves. Materials Science and Engineering: C. 2015; 48:556–65.FallahiarezoudarEAhmadipourroudposhtMIdrisAA review of: application of synthetic scaffold in tissue engineering heart valves2015485566510.1016/j.msec.2014.12.016Search in Google Scholar
Jiao T, Clifton RJ, Converse GL, et al. Measurements of the effects of decellularization on viscoelastic properties of tissues in ovine, baboon, and human heart valves. Tissue Engineering Part A. 2012; 18(3–4):423–31.JiaoTCliftonRJConverseGLMeasurements of the effects of decellularization on viscoelastic properties of tissues in ovine, baboon, and human heart valves2012183–44233110.1089/ten.tea.2010.0677Search in Google Scholar
Shojima T, Yoshikawa K, Hori H, et al. In vivo recellularization of plain decellularized xenografts with specific cell characterization in the systemic circulation: histological and immunohistochemical study. Artificial Organs. 2006; 30(4): 233–41.ShojimaTYoshikawaKHoriHIn vivo recellularization of plain decellularized xenografts with specific cell characterization in the systemic circulation: histological and immunohistochemical study20063042334110.1111/j.1525-1594.2006.00210.xSearch in Google Scholar
Honge JL, Funder J, Hansen E, et al. Recellularization of aortic valves in pigs. Journal Of Cardiothoracic Surgery. 2011; 39(6):829–34.HongeJLFunderJHansenERecellularization of aortic valves in pigs20113968293410.1016/j.ejcts.2010.08.054Search in Google Scholar
Harken DE. Heart valves: ten commandments and still counting. The Annals of Thoracic Surgery. 48 (Suppl. 3), 18–19 (1989).HarkenDEHeart valves: ten commandments and still counting48Suppl. 31819198910.1016/0003-4975(89)90623-1Search in Google Scholar
Hasan A, Ragaert K, Swieszkowski W, et al. Biomechanical properties of native and tissue engineered heart valve constructs. Journal Of Biomechanics. 2014; 47:1949.HasanARagaertKSwieszkowskiWBiomechanical properties of native and tissue engineered heart valve constructs201447194910.1016/j.jbiomech.2013.09.02324290137Search in Google Scholar
van Geemen D, Soares ALF, Oomen PJA, et al. Age-dependent changes in geometry, tissue composition and mechanical properties of fetal to adult cryopreserved human heart valves. PloS one. 2016; 11(2): e0149020.van GeemenDSoaresALFOomenPJAAge-dependent changes in geometry, tissue composition and mechanical properties of fetal to adult cryopreserved human heart valves2016112e014902010.1371/journal.pone.0149020475093626867221Search in Google Scholar
Langer R, Vacanti JP. Tissue engineering. Science. 1993; 260: 920–6.LangerRVacantiJPTissue engineering1993260920610.1201/9781420051834.sec1Search in Google Scholar
Schmidt JB, Tranquillo RT. Tissue Engineered Heart valves. In Heart valves From Design to Clinical Implantation. EDS: Iaizzo PA, Bianco RW, Hill A, et al. Spinger Science+ Business Media, New York, 2013, 261–80.SchmidtJBTranquilloRTTissue Engineered Heart valvesInEDS:IaizzoPABiancoRWHillASpinger Science+ Business MediaNew York20132618010.1007/978-1-4614-6144-9_11Search in Google Scholar
Chen Q, Bruyneel A, Carr C, et al. Bio-mechanical properties of novel bi-layer collagen-elastin scaffolds for heart valve tissue engineering. Procedia Engineering. 2013; 59: 247–54.ChenQBruyneelACarrCBio-mechanical properties of novel bi-layer collagen-elastin scaffolds for heart valve tissue engineering2013592475410.1016/j.proeng.2013.05.118Search in Google Scholar
Long JL, Tranquillo RT. Elastic fiber production in cardiovascular tissue-equivalents. Matrix biology. 2003; 22(4): 339–50.LongJLTranquilloRTElastic fiber production in cardiovascular tissue-equivalents20032243395010.1016/S0945-053X(03)00052-0Search in Google Scholar
Duan B, Hockaday LA, Kang KH, et al. 3D bioprinting of heterogeneous aortic valve conduits with alginate/gelatin hydrogels. Journal of biomedical materials research Part A. 2013; 101(5): 1255–64.DuanBHockadayLAKangKH3D bioprinting of heterogeneous aortic valve conduits with alginate/gelatin hydrogels2013101512556410.1002/jbm.a.34420369436023015540Search in Google Scholar
Mela P, Hinderer S, Kandil HS, et al. Tissue-engineered heart valves. In Principles of heart valve engineering. Ed: Arash Kheradvar. Elsevier Academic Press. California, USA, 2019, pag 135.MelaPHindererSKandilHSTissue-engineered heart valvesInEd:KheradvarArashElsevier Academic PressCalifornia, USA201913510.1016/B978-0-12-814661-3.00006-XSearch in Google Scholar
Boroumand S, Asadpour S, Akbarzadeh A, et al. Heart valve tissue engineering: an overview of heart valve decellularization processes. Regenerative medicine. 2018; 13(1): 41–54.BoroumandSAsadpourSAkbarzadehAHeart valve tissue engineering: an overview of heart valve decellularization processes2018131415410.2217/rme-2017-006129360011Search in Google Scholar
Fallon AM, Goodchild TT, Cox JL, et al. In vivo remodeling potential of a novel bioprosthetic tricuspid valve in an ovine model. Journal of Thoracic and Cardiovascular Surgery. 2014; 148 (1): 333–40.FallonAMGoodchildTTCoxJLIn vivo remodeling potential of a novel bioprosthetic tricuspid valve in an ovine model201414813334010.1016/j.jtcvs.2013.10.04824360254Search in Google Scholar
Haupt J, Lutter G, Gorb S et al. Detergent-based decellularization strategy preserves macro-and microstructure of heart valves. Interactive cardiovascular and thoracic surgery. 2018; 26(2): 230–6.HauptJLutterGGorbSDetergent-based decellularization strategy preserves macro-and microstructure of heart valves2018262230610.1093/icvts/ivx31629155942Search in Google Scholar
Iop L, Paolin A, Aguiari P, et al. Decellularized cryopreserved allografts as off-the-shelf allogeneic alternative for heart valve replacement: in vitro assessment before clinical translation. Journal of cardiovascular translational research. 2017; 10(2): 93–103.IopLPaolinAAguiariPDecellularized cryopreserved allografts as off-the-shelf allogeneic alternative for heart valve replacement: in vitro assessment before clinical translation20171029310310.1007/s12265-017-9738-028281241Search in Google Scholar
VeDepo MC, Buse EE, Quinn, et al. Species-specific effects of aortic valve decellularization. Acta biomaterialia. 2017; 50:249–58.VeDepoMCBuseEEQuinnSpecies-specific effects of aortic valve decellularization2017502495810.1016/j.actbio.2017.01.00828069510Search in Google Scholar
Crapo PM, Gilbert TW and Badylak SF. An overview of tissue and whole organ decellularization processes. Biomaterials. 2011; 32: 3233–43.CrapoPMGilbertTWBadylakSFAn overview of tissue and whole organ decellularization processes20113232334310.1016/j.biomaterials.2011.01.057308461321296410Search in Google Scholar
Bloch O, Erdbrugger W, Volker W, et al. Extracellular matrix in deoxycholic acid decellularized aortic heart valves. Medical Science Monitor. 2012; 18: 487–92.BlochOErdbruggerWVolkerWExtracellular matrix in deoxycholic acid decellularized aortic heart valves2012184879210.12659/MSM.883618Search in Google Scholar
Somers P, De Somer F, Cornelissen M, et al. Decellularization of heart valve matrices: search for the ideal balance. Artificial Cells Blood Substitutes And Immobilization Biotechnology. 2012; 40: 151–62.SomersPDe SomerFCornelissenMDecellularization of heart valve matrices: search for the ideal balance2012401516210.3109/10731199.2011.637925Search in Google Scholar
Zhou J, Fritze O, Schleicher M, et al. Impact of heart valve decellularization on 3-D ultrastructure, immunogenicity and thrombogenicity. Biomaterials. 2010; 31: 2549–54.ZhouJFritzeOSchleicherMImpact of heart valve decellularization on 3-D ultrastructure, immunogenicity and thrombogenicity20103125495410.1016/j.biomaterials.2009.11.088Search in Google Scholar
Erdbrugger W, Konertz P, Dohmen M, et al. Decellularized xenogenic heart valves reveal remodeling and growth potential in vivo. Tissue Engineering. 2006; 12:2059–68.ErdbruggerWKonertzPDohmenMDecellularized xenogenic heart valves reveal remodeling and growth potential in vivo20061220596810.1089/ten.2006.12.2059Search in Google Scholar
Meyer SR, Chiu B, Churchill TA, et al. Comparison of aortic valve allograft decellularization techniques in the rat. Journal Of Biomedical Materials Research Part A. 2006; 79: 254–62.MeyerSRChiuBChurchillTAComparison of aortic valve allograft decellularization techniques in the rat2006792546210.1002/jbm.a.30777Search in Google Scholar
Sierad LN, Shaw EL, Bina, et al. Functional heart valve scaffolds obtained by complete decellularization of porcine aortic roots in a novel differential pressure gradient perfusion system. Tissue Engineering Part C: Methods. 2015; 21(12): 1284–96.SieradLNShawELBinaFunctional heart valve scaffolds obtained by complete decellularization of porcine aortic roots in a novel differential pressure gradient perfusion system2015211212849610.1089/ten.tec.2015.0170Search in Google Scholar
Theodoridis K, Tudorache I, Calistru A, et al. Successful matrix guided tissue regeneration of decellularized pulmonary heart valve allografts in elderly sheep. Biomaterials. 2015; 52: 221–8.TheodoridisKTudoracheICalistruASuccessful matrix guided tissue regeneration of decellularized pulmonary heart valve allografts in elderly sheep201552221810.1016/j.biomaterials.2015.02.023Search in Google Scholar
Ye X, Zhao Q, Sun X, et al. Enhancement of mesenchymal stem cell attachment to decellularized porcine aortic valve scaffold by in vitro coating with antibody against CD90: a preliminary study on antibody-modified tissue-engineered heart valve. Tissue Engineering Part A. 2009; 15: 1–11.YeXZhaoQSunXEnhancement of mesenchymal stem cell attachment to decellularized porcine aortic valve scaffold by in vitro coating with antibody against CD90: a preliminary study on antibody-modified tissue-engineered heart valve20091511110.1089/ten.tea.2008.0001Search in Google Scholar
Mi HY, Salick MR, Jing X, et al. Characterization of thermoplastic polyurethane/polylactic acid (TPU/PLA) tissue engineering scaffolds fabricated by microcellular injection molding. Materials Science And Engineering. 2013; 33 (8): 4767–76.MiHYSalickMRJingXCharacterization of thermoplastic polyurethane/polylactic acid (TPU/PLA) tissue engineering scaffolds fabricated by microcellular injection molding201333847677610.1016/j.msec.2013.07.037Search in Google Scholar
Chen GP, Ushida T, Tateishi T. Development of biodegradable porous scaffolds for tissue engineering. Materials Science & Engineering C-Materials For Biological Applications. 2001; 17: 63–9.ChenGPUshidaTTateishiTDevelopment of biodegradable porous scaffolds for tissue engineering20011763910.1016/S0928-4931(01)00338-1Search in Google Scholar
Sodian R, Hoerstrup SP, Sperling, et al. Early in vivo experience with tissue-engineered trileaflet heart valves. Circulation. 2000; 102: Iii–22.SodianRHoerstrupSPSperlingEarly in vivo experience with tissue-engineered trileaflet heart valves2000102Iii2210.1161/01.CIR.102.suppl_3.III-22Search in Google Scholar
Sung HJ, Meredith C, Johnson, et al. The effect of scaffold degradation rate on three-dimensional cell growth and angiogenesis. Biomaterials. 2004; 25(26): 5735–42.SungHJMeredithCJohnsonThe effect of scaffold degradation rate on three-dimensional cell growth and angiogenesis2004252657354210.1016/j.biomaterials.2004.01.06615147819Search in Google Scholar
Baji A, Mai YW, Wong SC, et al. Electrospinning of polymer nanofibers: effects on oriented morphology, structures and tensile properties. Composites Science And Technology. 2010; 70: 703–18.BajiAMaiYWWongSCElectrospinning of polymer nanofibers: effects on oriented morphology, structures and tensile properties2010707031810.1016/j.compscitech.2010.01.010Search in Google Scholar
Mendelson K, Schoen FJ. Heart valve tissue engineering: concepts, approaches, progress, and challenges. Annals of biomedical engineering. 2006; 34(12): 1799–819.MendelsonKSchoenFJHeart valve tissue engineering: concepts, approaches, progress, and challenges20063412179981910.1007/s10439-006-9163-z170550617053986Search in Google Scholar
Hinton RB, Yutzey KE Heart valve structure and function in development and disease. Annual Review Of Physiology. 2011; 73: 29–46.HintonRBYutzeyKEHeart valve structure and function in development and disease201173294610.1146/annurev-physiol-012110-142145420940320809794Search in Google Scholar
Ikada Y. Challenges in tissue engineering. Journal Of The Royal Society Interface. 2006; 3: 589–601.IkadaYChallenges in tissue engineering2006358960110.1098/rsif.2006.0124166465516971328Search in Google Scholar
Tedder ME, Simionescu A, Chen, et al. Assembly and testing of stem cell-seeded layered collagen constructs for heart valve tissue engineering. Tissue Engineering Part A. 2011; 17(1–2): 25–36.TedderMESimionescuAChenAssembly and testing of stem cell-seeded layered collagen constructs for heart valve tissue engineering2011171–2253610.1089/ten.tea.2010.0138301192220673028Search in Google Scholar
Weymann A, Schmack B, Okada T, et al. Reendothelialization of human heart valve neoscaffolds using umbilical cord-derived endothelial cells. Circulation Journal. 2012: CJ–12.WeymannASchmackBOkadaTReendothelialization of human heart valve neoscaffolds using umbilical cord-derived endothelial cells2012CJ1210.1253/circj.CJ-12-054023001070Search in Google Scholar
Hong H, Dong NG, Shi JW et al. Fabrication of a novel hybrid heart valve leaflet for tissue engineering: an in vitro study. Artificial Organs. 2009; 33: 554–7.HongHDongNGShiJWFabrication of a novel hybrid heart valve leaflet for tissue engineering: an in vitro study200933554710.1111/j.1525-1594.2009.00742.x19566733Search in Google Scholar
Kolios G, Moodley Y. Introduction to stem cells and regenerative medicine. Respiration. 2013; 85(1): 3–10.KoliosGMoodleyYIntroduction to stem cells and regenerative medicine201385131010.1159/00034561523257690Search in Google Scholar
Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006;126:663–76.TakahashiKYamanakaSInduction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors20061266637610.1016/j.cell.2006.07.024Search in Google Scholar
Ilic D, Polak JM. Stem cells in regenerative medicine: introduction. British Medical Bulletin. 2011;98:117–126.IlicDPolakJMStem cells in regenerative medicine: introduction20119811712610.1093/bmb/ldr012Search in Google Scholar
Evans MJ, Kaufman MH. Establishment in culture of pluripotential cells from mouse embryos. Nature. 1981;292:154–6.EvansMJKaufmanMHEstablishment in culture of pluripotential cells from mouse embryos1981292154610.1038/292154a0Search in Google Scholar
Mahla RS. Stem cells applications in regenerative medicine and disease therapeutics. International journal of cell biology. 2016.MahlaRSStem cells applications in regenerative medicine and disease therapeutics201610.1155/2016/6940283Search in Google Scholar
Jana S, Tranquillo RT, Lerman A. Cells for tissue engineering of cardiac valves. Journal of tissue engineering and regenerative medicine. 2016; 10(10):804–24.JanaSTranquilloRTLermanACells for tissue engineering of cardiac valves201610108042410.1002/term.2010Search in Google Scholar
Gong Z, Niklason LE. Use of human mesenchymal stem cells as alternative source of smooth muscle cells in vessel engineering. Methods in Molecular Biology. 2011; 698: 279–94.GongZNiklasonLEUse of human mesenchymal stem cells as alternative source of smooth muscle cells in vessel engineering20116982799410.1007/978-1-60761-999-4_21Search in Google Scholar
Wang S, Qu X, Zhao RC. Clinical applications of mesenchymal stem cells. Journal of hematology & oncology. 2012; 5(1):1–9.WangSQuXZhaoRCClinical applications of mesenchymal stem cells2012511910.1186/1756-8722-5-19Search in Google Scholar
Lichtenberg A, Tudorache I, Cebotari S, et al. Preclinical testing of tissue-engineered heart valves re-endothelialized under simulated physiological conditions. Circulation. 2006; 114: 559.LichtenbergATudoracheICebotariSPreclinical testing of tissue-engineered heart valves re-endothelialized under simulated physiological conditions200611455910.1161/CIRCULATIONAHA.105.001206Search in Google Scholar
Dohmen PM, Lembcke A, Holinski, et al. Ten years of clinical results with a tissue-engineered pulmonary valve. The Annals of thoracic surgery. 2011; 92(4): 1308–14.DohmenPMLembckeAHolinskiTen years of clinical results with a tissue-engineered pulmonary valve201192413081410.1016/j.athoracsur.2011.06.009Search in Google Scholar
Herring M, Smith J, Dalsing M, et al. Endothelial seeding of polytetrafluoroethylene femoral popliteal bypasses: the failure of low-density seeding to improve patency. Journal of vascular surgery. 1994; 20(4):650–5.HerringMSmithJDalsingMEndothelial seeding of polytetrafluoroethylene femoral popliteal bypasses: the failure of low-density seeding to improve patency1994204650510.1016/0741-5214(94)90291-7Search in Google Scholar
Aleksieva G, Hollweck T, Thierfelder N, et al. Use of a special bioreactor for the cultivation of a new flexible polyurethane scaffold for aortic valve tissue engineering. Biomedical engineering online. 2012; 11(1): 1–11.AleksievaGHollweckTThierfelderNUse of a special bioreactor for the cultivation of a new flexible polyurethane scaffold for aortic valve tissue engineering201211111110.1186/1475-925X-11-92353860823206816Search in Google Scholar
Amrollahi P, Tayebi L. Bioreactors for heart valve tissue engineering: a review. Journal of Chemical Technology & Biotechnology. 2016; 91(4): 847–56.AmrollahiPTayebiLBioreactors for heart valve tissue engineering: a review20169148475610.1002/jctb.4825Search in Google Scholar
Converse GL, Buse EE, Neill KR, et al. Design and efficacy of a single-use bioreactor for heart valve tissue engineering. Journal of Biomedical Materials Research Part B: Applied Biomaterials. 2015; 105(2): 249–59.ConverseGLBuseEENeillKRDesign and efficacy of a single-use bioreactor for heart valve tissue engineering201510522495910.1002/jbm.b.3355226469196Search in Google Scholar
Reimer J, Syedain Z, Haynie B, et al. Implantation of a tissue-engineered tubular heart valve in growing lambs. Annals of biomedical engineering. 2017; 45(2): 439–51.ReimerJSyedainZHaynieBImplantation of a tissue-engineered tubular heart valve in growing lambs20174524395110.1007/s10439-016-1605-7506482827066787Search in Google Scholar
Moreira R, Velz T, Alves N, et al. Tissue-engineered heart valve with a tubular leaflet design for minimally invasive transcatheter implantation. Tissue Engineering Part C: Methods. 2015; 21(6): 530–540.MoreiraRVelzTAlvesNTissue-engineered heart valve with a tubular leaflet design for minimally invasive transcatheter implantation201521653054010.1089/ten.tec.2014.0214444259725380414Search in Google Scholar
Harpa M, Movileanu I, Sierad L, et al. In vivo testing of xenogeneic acellular aortic valves seeded with stem cells. Revista Romana de Medicina de Laborator. 2016; 24(3): 343HarpaMMovileanuISieradLIn vivo testing of xenogeneic acellular aortic valves seeded with stem cells201624334310.1515/rrlm-2016-0031651653531098341Search in Google Scholar
Harpa M, Movileanu I, Sierad LN, et al. Pulmonary heart valve replacement using stabilized acellular xenogeneic scaffolds effects of seeding with autologous stem cells. Revista Romana de Medicina de Laborator. 2015; 23(4): 415–430.HarpaMMovileanuISieradLNPulmonary heart valve replacement using stabilized acellular xenogeneic scaffolds effects of seeding with autologous stem cells201523441543010.1515/rrlm-2015-0046Search in Google Scholar
Gallo M, Naso F, Poser H, et al. Physiological performance of a detergent decellularized heart valve implanted for 15 months in Vietnamese pigs: surgical procedure, follow-up, and explant inspection. Artificial organs. 2012; 36(6): 138–50.GalloMNasoFPoserHPhysiological performance of a detergent decellularized heart valve implanted for 15 months in Vietnamese pigs: surgical procedure, follow-up, and explant inspection20123661385010.1111/j.1525-1594.2012.01447.x22512408Search in Google Scholar
Quinn RW, Bert AA, Converse GL, et al. Performance of allogeneic bioengineered replacement pulmonary valves in rapidly growing young lambs. Journal of Thoracic and Cardiovascular Surgery. 2016; 152(4):1156–65.QuinnRWBertAAConverseGLPerformance of allogeneic bioengineered replacement pulmonary valves in rapidly growing young lambs2016152411566510.1016/j.jtcvs.2016.05.05127641300Search in Google Scholar
Iwai S, Torikai K, Coppin CM, et al. Minimally immunogenic decellularized porcine valve provides in situ recellularization as a stentless bioprosthetic valve. Journal Of Artificial Organs. 2007; 10: 29–35.IwaiSTorikaiKCoppinCMMinimally immunogenic decellularized porcine valve provides in situ recellularization as a stentless bioprosthetic valve200710293510.1007/s10047-006-0360-117380294Search in Google Scholar
Hopkins RA, Bert AA, Hilbert SL, et al. Bioengineered human and allogeneic pulmonary valve conduits chronically implanted orthotopically in baboons: Hemodynamic performance and immunologic consequences. Journal of Thoracic and Cardiovascular Surgery. 2013; 145:1098–1107.HopkinsRABertAAHilbertSLBioengineered human and allogeneic pulmonary valve conduits chronically implanted orthotopically in baboons: Hemodynamic performance and immunologic consequences20131451098110710.1016/j.jtcvs.2012.06.024Search in Google Scholar
Handbook of cardiac anatomy, physiology, and devices. Ed: Iaizzo, PA. Springer Science & Business Media, Switzerland, 2009.Ed:IaizzoPASpringer Science & Business MediaSwitzerland200910.1007/978-1-60327-372-5Search in Google Scholar
Shinoka T, Breuer CK, Tanel RE, et al. Tissue engineering heart valves: valve leaflet replacement study in a lamb model. The Annals of thoracic surgery. 1995; 60: S513–S516.ShinokaTBreuerCKTanelRETissue engineering heart valves: valve leaflet replacement study in a lamb model199560S513S51610.1016/S0003-4975(21)01185-1Search in Google Scholar
O’Brien MF, Goldstein S, Walsh S, et al. The Syner Graft valve: a new acellular (nonglutaraldehyde-fixed) tissue heart valve for autologous recellularization first experimental studies before clinical implantation. In Seminars in thoracic and cardiovascular surgery. 1999; 11: 194–200O’BrienMFGoldsteinSWalshSThe Syner Graft valve: a new acellular (nonglutaraldehyde-fixed) tissue heart valve for autologous recellularization first experimental studies before clinical implantation199911194200Search in Google Scholar
Dohmen PM, Ozaki S, Nitsch R, et al. A tissue engineered heart valve implanted in a juvenile sheep model. Medical Science Monitor. 2003; 9(4): 97–104.DohmenPMOzakiSNitschRA tissue engineered heart valve implanted in a juvenile sheep model20039497104Search in Google Scholar
Leyh RG, Wilhelmi M, Walles T, et al. Acellularized porcine heart valve scaffolds for heart valve tissue engineering and the risk of cross-species transmission of porcine endogenous retrovirus. The Journal of thoracic and cardiovascular surgery. 2003; 126(4): 1000–1004.LeyhRGWilhelmiMWallesTAcellularized porcine heart valve scaffolds for heart valve tissue engineering and the risk of cross-species transmission of porcine endogenous retrovirus200312641000100410.1016/S0022-5223(03)00353-2Search in Google Scholar
Dohmen P, Da Costa F, Yoshi L S, et al. An experimental study of decellularized xenografts implanted into the aortic position with 4 months of follow up. Journal of Clinical and Experimental Cardiology. 2012; 4:2.DohmenPDa CostaFYoshiL SAn experimental study of decellularized xenografts implanted into the aortic position with 4 months of follow up20124210.4172/2155-9880.S4-004Search in Google Scholar
Hennessy RS, Go JL, Hennessy RR, et al. Recellularization of a novel off-the-shelf valve following xenogenic implantation into the right ventricular outflow tract. PloS one. 2017; 12(8): e0181614.HennessyRSGoJLHennessyRRRecellularization of a novel off-the-shelf valve following xenogenic implantation into the right ventricular outflow tract2017128e018161410.1371/journal.pone.0181614553866128763463Search in Google Scholar
Dohmen PM, Fd C, Lopes SV, et al. Results of a decellularized porcine heart valve implanted into the juvenile sheep model. In The heart surgery forum. 2005; 8(2): E100–4DohmenPMFdCLopesSVResults of a decellularized porcine heart valve implanted into the juvenile sheep model200582E100410.1532/HSF98.2004114015769723Search in Google Scholar
Zafar F, Hinton RB, Moore RA, et al. Physiological growth, remodeling potential, and preserved function of a novel bioprosthetic tricuspid valve: tubular bioprosthesis made of small intestinal submucosa-derived extracellular matrix. Journal of the American College of Cardiology. 2015; 66(8): 877–888.ZafarFHintonRBMooreRAPhysiological growth, remodeling potential, and preserved function of a novel bioprosthetic tricuspid valve: tubular bioprosthesis made of small intestinal submucosa-derived extracellular matrix201566887788810.1016/j.jacc.2015.06.109126293756Search in Google Scholar
Van Rijswijk, Jan W, Talacua H, et al. Failure of decellularized porcine small intestinal submucosa as a heart valved conduit. The Journal of thoracic and cardiovascular surgery. 2020; 160(4): e201–e215.Van RijswijkJanWTalacuaHFailure of decellularized porcine small intestinal submucosa as a heart valved conduit20201604e201e21510.1016/j.jtcvs.2019.09.16432151387Search in Google Scholar
Motta SE, Lintas V, Fioretta ES, et al. Human cell-derived tissue-engineered heart valve with integrated Valsalva sinuses: towards native-like transcatheter pulmonary valve replacements. NPJ Regenerative medicine. 2019; 4(1): 1–10.MottaSELintasVFiorettaESHuman cell-derived tissue-engineered heart valve with integrated Valsalva sinuses: towards native-like transcatheter pulmonary valve replacements20194111010.1038/s41536-019-0077-4657286131240114Search in Google Scholar
Driessen-Mol A, Emmert MY, Dijkman PE, et al. Transcatheter implantation of homologous “off-the-shelf” tissue-engineered heart valves with self-repair capacity: long-term functionality and rapid in vivo remodeling in sheep. Journal of the American College of Cardiology. 2014; 63(13): 1320–1329.Driessen-MolAEmmertMYDijkmanPETranscatheter implantation of homologous “off-the-shelf” tissue-engineered heart valves with self-repair capacity: long-term functionality and rapid in vivo remodeling in sheep201463131320132910.1016/j.jacc.2013.09.082Search in Google Scholar
Motta SE, Fioretta ES, Dijkman PE, et al. Development of an off the-shelf tissue-engineered sinus valve for transcatheter pulmonary valve replacement: a proof-of-concept study. Journal of cardiovascular translational research. 2018; 11(3): 182–191.MottaSEFiorettaESDijkmanPEDevelopment of an off the-shelf tissue-engineered sinus valve for transcatheter pulmonary valve replacement: a proof-of-concept study201811318219110.1007/s12265-018-9800-6Search in Google Scholar
Dohmen PM, Lembcke A, Hotz H, et al. Ross operation with a tissue-engineered heart valve. Annals of Thoracic Surgery. 2002; 74(5): 1438–1442.DohmenPMLembckeAHotzHRoss operation with a tissue-engineered heart valve20027451438144210.1016/S0003-4975(02)03881-XSearch in Google Scholar
Simon P, Kasimir MT, Seebacher G, et al. Early failure of the tissue engineered porcine heart valve SYNERGRAFT® in pediatric patients. European journal of cardio-thoracic surgery. 2003; 23(6): 1002–1006.SimonPKasimirMTSeebacherGEarly failure of the tissue engineered porcine heart valve SYNERGRAFT® in pediatric patients20032361002100610.1016/S1010-7940(03)00094-0Search in Google Scholar
Rüffer A, Purbojo A, Cicha I, et al. Early failure of xenogenous de-cellularised pulmonary valve conduits—a word of caution!. European journal of cardio-thoracic surgery. 2010; 38(1): 78–85.RüfferAPurbojoACichaIEarly failure of xenogenous de-cellularised pulmonary valve conduits—a word of caution!2010381788510.1016/j.ejcts.2010.01.04420219384Search in Google Scholar
Konertz W, Angeli E, Tarusinov G, et al. Right ventricular outflow tract reconstruction with decellularized porcine xenografts in patients with congenital heart disease. Journal of Heart Valve Disease. 2011; 20(3): 341.KonertzWAngeliETarusinovGRight ventricular outflow tract reconstruction with decellularized porcine xenografts in patients with congenital heart disease2011203341Search in Google Scholar
Perri G, Polito A, Esposito C, et al. Early and late failure of tissue-engineered pulmonary valve conduits used for right ventricular outflow tract reconstruction in patients with congenital heart disease. European journal of cardio-thoracic surgery. 2012; 41(6): 1320–1325.PerriGPolitoAEspositoCEarly and late failure of tissue-engineered pulmonary valve conduits used for right ventricular outflow tract reconstruction in patients with congenital heart disease20124161320132510.1093/ejcts/ezr22122219487Search in Google Scholar
Voges I, Bräsen JH, Entenmann A, et al. Adverse results of a decellularized tissue-engineered pulmonary valve in humans assessed with magnetic resonance imaging. European Journal of Cardio-Thoracic Surgery. 2013; 44(4): e272–e279.VogesIBräsenJHEntenmannAAdverse results of a decellularized tissue-engineered pulmonary valve in humans assessed with magnetic resonance imaging2013444e272e27910.1093/ejcts/ezt32823818571Search in Google Scholar
Breitenbach I, El-Essawi A, Pahari D, et al. Early failure of decellularized xenogenous pulmonary valve conduit (Matrix-P-Plus) for reconstruction of the right ventricular outflow tract in the Ross procedure. The Thoracic and Cardiovascular Surgeon. 2014; 62(S 01): OP123.BreitenbachIEl-EssawiAPahariDEarly failure of decellularized xenogenous pulmonary valve conduit (Matrix-P-Plus) for reconstruction of the right ventricular outflow tract in the Ross procedure201462S 01OP12310.1055/s-0034-1367197Search in Google Scholar
Christ T, Paun AC, Grubitzsch H, et al. Long-term results after the Ross procedure with the decellularized AutoTissue Matrix P® bioprosthesis used for pulmonary valve replacement. European Journal of Cardio-Thoracic Surgery. 2019; 55(5): 885–892.ChristTPaunACGrubitzschHLong-term results after the Ross procedure with the decellularized AutoTissue Matrix P® bioprosthesis used for pulmonary valve replacement201955588589210.1093/ejcts/ezy37730508165Search in Google Scholar
Dohmen PM, Lembcke A, Holinski S, et al. Mid-term clinical results using a tissue-engineered pulmonary valve to reconstruct the right ventricular outflow tract during the Ross procedure. The Annals of thoracic surgery. 2007; 84(3): 729–736.DohmenPMLembckeAHolinskiSMid-term clinical results using a tissue-engineered pulmonary valve to reconstruct the right ventricular outflow tract during the Ross procedure200784372973610.1016/j.athoracsur.2007.04.07217720368Search in Google Scholar
Dohmen PM, Lembcke A, Holinski S, et al. Ten years of clinical results with a tissue-engineered pulmonary valve. The Annals of thoracic surgery. 2011; 92(4): 1308–1314.DohmenPMLembckeAHolinskiSTen years of clinical results with a tissue-engineered pulmonary valve20119241308131410.1016/j.athoracsur.2011.06.00921958777Search in Google Scholar
Boethig D, Horke A, Hazekamp M, et al. A European study on decellularized homografts for pulmonary valve replacement: initial results from the prospective ESPOIR Trial and ESPOIR Registry data. European Journal of Cardio-Thoracic Surgery. 2019; 56(3):503–509.BoethigDHorkeAHazekampMA European study on decellularized homografts for pulmonary valve replacement: initial results from the prospective ESPOIR Trial and ESPOIR Registry data201956350350910.1093/ejcts/ezz054673576330879050Search in Google Scholar
Tudorache I, Horke A, Cebotari S, et al. Decellularized aortic homo-grafts for aortic valve and aorta ascendens replacement. European Journal of Cardio-thoracic Surgery. 2016; 50(1): 89–97.TudoracheIHorkeACebotariSDecellularized aortic homo-grafts for aortic valve and aorta ascendens replacement2016501899710.1093/ejcts/ezw013491387526896320Search in Google Scholar