<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Psychoneuroendocrine immunology is an integrated field that explores the pathways through which psychological experiences influence immune function and how the immune system, in turn, might alter brain function. The glial-lymphatic system regulates fluid balance and waste removal in the central nervous system, which lacks an independent lymphatic system (glymphatic system). We looked for literature on stress, its consequences, and the glymphatic system in PubMed/MEDLINE, Google Scholar, Scopus, and other online databases. Work, examinations, physical, and mental stress brought on by sickness, trauma, and other everyday occurrences are just a few examples of situations that might be categorized as “stressful.” The “fight-flight-freeze response” is the name given to the body’s combination of adaptations in reaction to stress. Sleep problems are associated with higher levels of stress. It is plausible to assume that this is the mechanism through which stress affects glymphatic function given that the brain’s waste disposal system has been shown to be active during sleep. Studying whether stress reduction can enhance brain waste removal and the prognosis of illnesses marked by metabolite accumulation is promising.</p>
</abstract>

Psychoneuroendocrine immunology is an integrated field that explores the pathways through which psychological experiences influence immune function and how the immune system, in turn, might alter brain function. The glial-lymphatic system regulates fluid balance and waste removal in the central nervous system, which lacks an independent lymphatic system (glymphatic system). We looked for literature on stress, its consequences, and the glymphatic system in PubMed/MEDLINE, Google Scholar, Scopus, and other online databases. Work, examinations, physical, and mental stress brought on by sickness, trauma, and other everyday occurrences are just a few examples of situations that might be categorized as “stressful.” The “fight-flight-freeze response” is the name given to the body’s combination of adaptations in reaction to stress. Sleep problems are associated with higher levels of stress. It is plausible to assume that this is the mechanism through which stress affects glymphatic function given that the brain’s waste disposal system has been shown to be active during sleep. Studying whether stress reduction can enhance brain waste removal and the prognosis of illnesses marked by metabolite accumulation is promising.

Effects of Stress on the Brain’s Glymphatic System

Department of Medical Microbiology and Immunology “ Prof. Dr. Elissay Yanev,” Faculty of Pharmacy, Contracts for University Research Complexes, Research Institute at MU-Plovdiv

University Hospital “St. George”-Plovdiv

South East European Journal of Immunology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Effects of Stress on the Brain\u2019s Glymphatic System"}

Psychoneuroendocrine immunology is an integrated field that explores the pathways through which psychological experiences influence immune function and how the...

Effects of Stress on the Brain’s Glymphatic System

Data publikacji: 03 sty 2024

Zakres stron: 70 - 79

Otrzymano: 18 maj 2023

Przyjęty: 26 lip 2023

DOI: https://doi.org/10.3889/seejim.2023.6040

Słowa kluczowe
Glymphatic system, Stress, PNEI, Immune system, Neurodegenerative diseases

© 2023 Mariya Ivanovska et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Effects of Stress on the Brain’s Glymphatic System

Data publikacji: 03 sty 2024

Zakres stron: 70 - 79

Otrzymano: 18 maj 2023

Przyjęty: 26 lip 2023

DOI: https://doi.org/10.3889/seejim.2023.6040

Słowa kluczoweGlymphatic system, Stress, PNEI, Immune system, Neurodegenerative diseases

© 2023 Mariya Ivanovska et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Słowa kluczowe
Glymphatic system, Stress, PNEI, Immune system, Neurodegenerative diseases