<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec><h3>BACKGROUND</h3>
<p>Leprosy, or Morbus Hansen, is a chronic granulomatous disease caused by <italic>Mycobacterium leprae</italic> that involves the skin and peripheral nerves, with or without motor disorders. Leprosy reactions are immune-mediated acute or subacute inflammatory episodes that interfere with chronic disease and are classified into three types: type 1 (RR), type 2 (ENL), and the Lucio phenomenon.</p>
</sec>
<sec><h3>AIM</h3>
<p>The purpose of the study is to describe the epidemiology of leprosy reactions at Universitas Sumatera Utara (USU) teaching hospitals and provide a description of factors associated with the reactions that might provide valuable information for future studies.</p>
</sec>
<sec><h3>METHODS</h3>
<p>This is a cross-sectional analytic study with total sampling on medical records of patients in the Dermatology and Venereology Polyclinic at H. Adam Malik Hospital Medan and USU Education Hospital in 2017–2021.</p>
</sec>
<sec><h3>RESULTS</h3>
<p>The incidence of leprosy reactions at the USU Medical Faculty Education Hospital in 2017–2021 was 41 cases. The majority of reaction types were type 2 reactions (68.3%). Risk factors for type 1 reactions were a history of reactions, being elderly, multiple lesions or nerve involvement, and co-infections, whereas the risk factors for type 2 reactions were LL, younger age, bacterial index >4+, stress, and co-infections. The highest age group proportion was 18–59 years (95.1%) and was more common in men (70.7%), which mostly appeared before treatment (39.1%). The incidence of leprosy reactions was 26 new cases per 100 patients.</p>
</sec>
<sec><h3>CONCLUSION</h3>
<p>The highest proportion of leprosy reactions was type 2, within the adult age group (18–59 years), males, and before treatment.</p>
</sec>
</abstract>

BACKGROUND
Leprosy, or Morbus Hansen, is a chronic granulomatous disease caused by Mycobacterium leprae that involves the skin and peripheral nerves, with or without motor disorders. Leprosy reactions are immune-mediated acute or subacute inflammatory episodes that interfere with chronic disease and are classified into three types: type 1 (RR), type 2 (ENL), and the Lucio phenomenon.

AIM
The purpose of the study is to describe the epidemiology of leprosy reactions at Universitas Sumatera Utara (USU) teaching hospitals and provide a description of factors associated with the reactions that might provide valuable information for future studies.

METHODS
This is a cross-sectional analytic study with total sampling on medical records of patients in the Dermatology and Venereology Polyclinic at H. Adam Malik Hospital Medan and USU Education Hospital in 2017–2021.

RESULTS
The incidence of leprosy reactions at the USU Medical Faculty Education Hospital in 2017–2021 was 41 cases. The majority of reaction types were type 2 reactions (68.3%). Risk factors for type 1 reactions were a history of reactions, being elderly, multiple lesions or nerve involvement, and co-infections, whereas the risk factors for type 2 reactions were LL, younger age, bacterial index >4+, stress, and co-infections. The highest age group proportion was 18–59 years (95.1%) and was more common in men (70.7%), which mostly appeared before treatment (39.1%). The incidence of leprosy reactions was 26 new cases per 100 patients.

CONCLUSION
The highest proportion of leprosy reactions was type 2, within the adult age group (18–59 years), males, and before treatment.

Overview of Leprosy Reactions at Universitas Sumatera Utara Medical Faculty Hospitals between 2017 and 2021

Department of Dermatology and Venereology

Faculty of Medicine Universitas Sumatera Utara/Adam Malik General Academic Hospital

Open Access Macedonian Journal of Medical Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License.

BACKGROUND
Leprosy, or Morbus Hansen, is a chronic granulomatous disease caused by Mycobacterium leprae that involves the skin and peripheral nerves, with or...

Overview of Leprosy Reactions at Universitas Sumatera Utara Medical Faculty Hospitals between 2017 and 2021

Data publikacji: 23 lut 2024

Zakres stron: 116 - 121

Otrzymano: 26 lis 2023

Przyjęty: 30 sty 2024

DOI: https://doi.org/10.3889/oamjms.2024.11837

Słowa kluczowe
Leprosy reaction, Leprosy, RR, ENL

© 2024 Ramona Dumasari Lubis et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License.

Overview of Leprosy Reactions at Universitas Sumatera Utara Medical Faculty Hospitals between 2017 and 2021

Data publikacji: 23 lut 2024

Zakres stron: 116 - 121

Otrzymano: 26 lis 2023

Przyjęty: 30 sty 2024

DOI: https://doi.org/10.3889/oamjms.2024.11837

Słowa kluczoweLeprosy reaction, Leprosy, RR, ENL

© 2024 Ramona Dumasari Lubis et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License.

Słowa kluczowe
Leprosy reaction, Leprosy, RR, ENL