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Comparative Analysis of Microbiological Profiles and Antibiotic Resistance Genes in Subjects with Colorectal Cancer and Healthy Individuals

Jun Li

Jun Li

Department of Gastroenterology, Second Medical Center, Chinese People’s Liberation Army General HospitalBeijing, China
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Li, Jun
, 
Yanyun Zhu

Yanyun Zhu

Department of Oncology, First Medical Center, Chinese People’s Liberation Army General HospitalBeijing, China
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Zhu, Yanyun
, 
Qing Chang

Qing Chang

Department of Gastroenterology, Second Medical Center, Chinese People’s Liberation Army General HospitalBeijing, China
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Chang, Qing
, 
Yuan Gong

Yuan Gong

Department of Gastroenterology, Second Medical Center, Chinese People’s Liberation Army General HospitalBeijing, China
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Gong, Yuan
, 
Jun Wan

Jun Wan

Department of Gastroenterology, Second Medical Center, Chinese People’s Liberation Army General HospitalBeijing, China
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Wan, Jun
 oraz 
Shiping Xu

Shiping Xu

Department of Gastroenterology, Second Medical Center, Chinese People’s Liberation Army General HospitalBeijing, China
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Xu, Shiping
  
26 mar 2025
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Kategoria artykułu: ORIGINAL PAPER
Data publikacji: 26 mar 2025
Zakres stron: 71 - 81
Otrzymano: 19 wrz 2024
Przyjęty: 21 sty 2025
DOI: https://doi.org/10.33073/pjm-2025-006
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© 2025 Jun Li et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Fig. 1.

Comparison of GIT microbial relative abundance at the phylum, genus and species level between CRC patients and healthy subjects. CRC – colorectal cancer, GIT – gastrointestinal tract
Comparison of GIT microbial relative abundance at the phylum, genus and species level between CRC patients and healthy subjects. CRC – colorectal cancer, GIT – gastrointestinal tract

Fig. 2.

Analysis of metabolic function between CRC – colorectal cancer patients and healthy subjects. A) Histogram of intestinal microbiota metabolism and functional gene relative abundance in patients with CRC and healthy controls; B) analysis of similarity in each group or between the two groups; C) relative abundance comparison in CRC patients and healthy controls.
Analysis of metabolic function between CRC – colorectal cancer patients and healthy subjects. A) Histogram of intestinal microbiota metabolism and functional gene relative abundance in patients with CRC and healthy controls; B) analysis of similarity in each group or between the two groups; C) relative abundance comparison in CRC patients and healthy controls.

Fig. 3.

Analysis of resistant genes between CRC patients and healthy subjects. A) Histogram of intestinal microbiota ARG relative abundance in patients with CRC and healthy controls; B) analysis of similarity in each group or between the two groups; C) comparison of intestinal microbiota ARGs between CRC patients and healthy controls. ARG – antibiotic resistance genes, CRC – colorectal cancer
Analysis of resistant genes between CRC patients and healthy subjects. A) Histogram of intestinal microbiota ARG relative abundance in patients with CRC and healthy controls; B) analysis of similarity in each group or between the two groups; C) comparison of intestinal microbiota ARGs between CRC patients and healthy controls. ARG – antibiotic resistance genes, CRC – colorectal cancer

Fig. 4.

Multivariate analysis of metabolic functions and resistant genes in CRC patients and healthy controls. CRC – colorectal cancer, LDA – linear discriminant analyse
Multivariate analysis of metabolic functions and resistant genes in CRC patients and healthy controls. CRC – colorectal cancer, LDA – linear discriminant analyse

Fig. 5.

Comparison of Actinobacteria at the A) order, B) family, C) genus and D) species level in CRC patients and the healthy control group. CRC – colorectal cancer
Comparison of Actinobacteria at the A) order, B) family, C) genus and D) species level in CRC patients and the healthy control group. CRC – colorectal cancer

Baseline characteristics of healthy controls and CRC patients_

Subject code Age (years), average (range)* Sex Weight (kg) Height (cm) Cancer history Medical history Diagnosis
Healthy controls ZJPQ 67 (44–71) Male 75 167 N/A N/A N/A
SKZL Male 74 172 N/A N/A N/A
LJQ Male 74 178 N/A N/A N/A
LDGL Male 75 178 N/A N/A N/A
HMXL Male 86 182 N/A N/A N/A
DHBL Male 73 167 N/A N/A N/A
CRC patients LYZ.1 57 (42–67) Male 59 170 No None CRC with liver metastasis for 1 month
ANJ.1 Male 70 165 No None CRC with liver metastasis for half month
LXL.1 Female 58 160 No Hypertension CRC
MYL.1 Female 57 157 No None CRC
XHM.1 Female 56 156 No None CRC with cervical lymph node metastasis for 5 days
GWX.1 Male 90 168 No None CRC with multiple metastases for 5 days
WZL.1 Male 73 172 No None CRC with multiple metastases for 1 month
Język:
Angielski
Częstotliwość wydawania:
4 razy w roku
Dziedziny czasopisma:
Nauki biologiczne, Mikrobiologia i wirusologia
Kanał RSS czasopisma