<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Non-steroidal anti-inflammatory drugs (NSAIDs) commonly used in clinical practice may cause gastrointestinal injuries and influence the gut microbiota. This study investigated the effects of various NSAIDs and some analgesics on the viability of <italic>Lactobacillaceae</italic> strains (including probiotic strains) <italic>in vitro</italic>. It was found that diclofenac, ibuprofen, ketoprofen, dexketoprofen, flurbiprofen, and acetylsalicylic acid inhibited the growth of lactobacilli at a concentration of 0.05−3.2 mg/ml. These MICs of NSAIDs are well above therapeutic plasma concentrations achieved in humans, indicating that the tested drugs should not inhibit the growth of lactobacilli in the human digestive tract.
<fig id="j_pjm-2023-038__fig_001" position="float" fig-type="figure">
<graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="graphic/j_pjm-2023-038_fig_001.jpg"></graphic>
</fig></p>
</abstract>

Non-steroidal anti-inflammatory drugs (NSAIDs) commonly used in clinical practice may cause gastrointestinal injuries and influence the gut microbiota. This study investigated the effects of various NSAIDs and some analgesics on the viability of Lactobacillaceae strains (including probiotic strains) in vitro. It was found that diclofenac, ibuprofen, ketoprofen, dexketoprofen, flurbiprofen, and acetylsalicylic acid inhibited the growth of lactobacilli at a concentration of 0.05−3.2 mg/ml. These MICs of NSAIDs are well above therapeutic plasma concentrations achieved in humans, indicating that the tested drugs should not inhibit the growth of lactobacilli in the human digestive tract.

Do NSAIDs and Other Pain Relief Drugs Can Inhibit the Growth of <italic>Lactobacillaceae</italic>?

Polish Journal of Microbiology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Do NSAIDs and Other Pain Relief Drugs Can Inhibit the Growth of ?

Non-steroidal anti-inflammatory drugs (NSAIDs) commonly used in clinical practice may cause gastrointestinal injuries and influence the gut microbiota. This...

Do NSAIDs and Other Pain Relief Drugs Can Inhibit the Growth of Lactobacillaceae?

Article Category: SHORT COMMUNICATION

Data publikacji: 16 gru 2023

Zakres stron: 507 - 513

Otrzymano: 04 lip 2023

Przyjęty: 13 wrz 2023

DOI: https://doi.org/10.33073/pjm-2023-038

Słowa kluczowe
analgesics, NSAIDs, probiotic bacteria, non-antibiotics

© 2023 Hanna Kruszewska et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Do NSAIDs and Other Pain Relief Drugs Can Inhibit the Growth of Lactobacillaceae?

Article Category: SHORT COMMUNICATION

Data publikacji: 16 gru 2023

Zakres stron: 507 - 513

Otrzymano: 04 lip 2023

Przyjęty: 13 wrz 2023

DOI: https://doi.org/10.33073/pjm-2023-038

Słowa kluczoweanalgesics, NSAIDs, probiotic bacteria, non-antibiotics

© 2023 Hanna Kruszewska et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Słowa kluczowe
analgesics, NSAIDs, probiotic bacteria, non-antibiotics