<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Enteroaggregative <italic>Escherichia coli</italic> (EAEC) strains have been linked to several outbreaks of severe diarrhea around the world, and this bacterium is now commonly resistant to antibiotics. As part of the pathophysiology of EAEC, the characteristic pattern of adherence looks like stacked bricks on the intestinal epithelium. This phenotype depends on an aggregative adhesion plasmid (pAA), which codes for a regulatory protein named AggR. The AggR protein is a master regulator that transcriptionally actives the main virulence genes in this <italic>E. coli</italic> pathotype, such as those that encode the aggregative adhesion fimbriae, dispersin and its secretion apparatus, Aar regulatory protein, and type VI secretion system. Several reports have shown that AggR positively affects most EAEC virulence genes, functioning as a classic transcriptional activator in the promoter region of these genes, interacting with the RNA polymerase. This minireview article integrates the information about virulence determinants of EAEC controlled by the AggR regulator.
<fig id="j_pjm-2023-037_fig_003" position="float" fig-type="figure">
<graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="graphic/j_pjm-2023-037_fig_003.jpg"></graphic>
</fig>
</p>
</abstract>

Enteroaggregative Escherichia coli (EAEC) strains have been linked to several outbreaks of severe diarrhea around the world, and this bacterium is now commonly resistant to antibiotics. As part of the pathophysiology of EAEC, the characteristic pattern of adherence looks like stacked bricks on the intestinal epithelium. This phenotype depends on an aggregative adhesion plasmid (pAA), which codes for a regulatory protein named AggR. The AggR protein is a master regulator that transcriptionally actives the main virulence genes in this E. coli pathotype, such as those that encode the aggregative adhesion fimbriae, dispersin and its secretion apparatus, Aar regulatory protein, and type VI secretion system. Several reports have shown that AggR positively affects most EAEC virulence genes, functioning as a classic transcriptional activator in the promoter region of these genes, interacting with the RNA polymerase. This minireview article integrates the information about virulence determinants of EAEC controlled by the AggR regulator.

A Mini-Review of Enteroaggregative <italic>Escherichia coli</italic> with a Specific Target on the Virulence Factors Controlled by the AggR Master Regulator

Polish Journal of Microbiology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

A Mini-Review of Enteroaggregative  with a Specific Target on the Virulence Factors Controlled by the AggR Master Regulator

Enteroaggregative Escherichia coli (EAEC) strains have been linked to several outbreaks of severe diarrhea around the world, and this bacterium is now commonly...

A Mini-Review of Enteroaggregative Escherichia coli with a Specific Target on the Virulence Factors Controlled by the AggR Master Regulator

Article Category: MINIREVIEW

Data publikacji: 16 gru 2023

Zakres stron: 347 - 354

Otrzymano: 23 cze 2023

Przyjęty: 08 wrz 2023

DOI: https://doi.org/10.33073/pjm-2023-037

Słowa kluczowe
aggregative adhesion fimbriae, AggR regulator, aggregative adhesion plasmid, dispersin, enteroaggregative

© 2023 Jeannett Alejandra Izquierdo-Vega et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

A Mini-Review of Enteroaggregative Escherichia coli with a Specific Target on the Virulence Factors Controlled by the AggR Master Regulator

Article Category: MINIREVIEW

Data publikacji: 16 gru 2023

Zakres stron: 347 - 354

Otrzymano: 23 cze 2023

Przyjęty: 08 wrz 2023

DOI: https://doi.org/10.33073/pjm-2023-037

Słowa kluczoweaggregative adhesion fimbriae, AggR regulator, aggregative adhesion plasmid, dispersin, enteroaggregative

© 2023 Jeannett Alejandra Izquierdo-Vega et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Słowa kluczowe
aggregative adhesion fimbriae, AggR regulator, aggregative adhesion plasmid, dispersin, enteroaggregative