<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>An imbalanced gut microbiome has been linked to a higher risk of many bone-related diseases. The objective of this study was to discover biomarkers of osteoporosis (OP). So, we collected 76 stool samples (60 human controls and 16 OP patients), extracted DNA, and performed 16S ribosomal ribonucleic acid (rRNA) gene-based amplicon sequencing. Among the taxa with an average taxonomic composition greater than 1%, only the <italic>Lachnospira</italic> genus showed a significant difference between the two groups. The Linear Discriminant Effect Size analysis and qPCR experiments indicated the <italic>Lachnospira</italic> genus as a potential biomarker of OP. Moreover, a total of 11 metabolic pathways varied between the two groups. Our study concludes that the genus <italic>Lachnospira</italic> is potentially crucial for diagnosing and treating osteoporosis. The findings of this study might help researchers better understand OP from a microbiome perspective. This research might develop more effective diagnostic and treatment methods for OP in the future.</p></abstract>

An imbalanced gut microbiome has been linked to a higher risk of many bone-related diseases. The objective of this study was to discover biomarkers of osteoporosis (OP). So, we collected 76 stool samples (60 human controls and 16 OP patients), extracted DNA, and performed 16S ribosomal ribonucleic acid (rRNA) gene-based amplicon sequencing. Among the taxa with an average taxonomic composition greater than 1%, only the Lachnospira genus showed a significant difference between the two groups. The Linear Discriminant Effect Size analysis and qPCR experiments indicated the Lachnospira genus as a potential biomarker of OP. Moreover, a total of 11 metabolic pathways varied between the two groups. Our study concludes that the genus Lachnospira is potentially crucial for diagnosing and treating osteoporosis. The findings of this study might help researchers better understand OP from a microbiome perspective. This research might develop more effective diagnostic and treatment methods for OP in the future.

Characterization of Fecal Microbiomes of Osteoporotic Patients in Korea

Polish Journal of Microbiology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Characterization of Fecal Microbiomes of Osteoporotic Patients in Korea"}

An imbalanced gut microbiome has been linked to a higher risk of many bone-related diseases. The objective of this study was to discover biomarkers of...

Characterization of Fecal Microbiomes of Osteoporotic Patients in Korea

Article Category: Original Paper

Data publikacji: 21 gru 2022

Zakres stron: 601 - 613

Otrzymano: 11 lip 2022

Przyjęty: 11 wrz 2022

DOI: https://doi.org/10.33073/pjm-2022-045

Słowa kluczowe
osteoporosis, microbiomes, gut microbiota, fecal microbiomes, 16S rRNA gene-based metagenomics,

© 2022 Asad Ul-Haq et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Characterization of Fecal Microbiomes of Osteoporotic Patients in Korea

Article Category: Original Paper

Data publikacji: 21 gru 2022

Zakres stron: 601 - 613

Otrzymano: 11 lip 2022

Przyjęty: 11 wrz 2022

DOI: https://doi.org/10.33073/pjm-2022-045

Słowa kluczoweosteoporosis, microbiomes, gut microbiota, fecal microbiomes, 16S rRNA gene-based metagenomics,

© 2022 Asad Ul-Haq et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Słowa kluczowe
osteoporosis, microbiomes, gut microbiota, fecal microbiomes, 16S rRNA gene-based metagenomics,