Fungal Infections in COVID-19 Intensive Care Patients

Al-Hatmi AMS, Mohsin J, Al-Huraizi A, Khamis F. COVID-19 associated invasive candidiasis. J Infect. 2021 Feb;82(2):e45–e46. https://doi.org/10.1016/j.jinf.2020.08.005Al-HatmiAMSMohsinJAl-HuraiziAKhamisF. COVID-19 associated invasive candidiasis. J Infect. 2021Feb;82(2):e45–e46. https://doi.org/10.1016/j.jinf.2020.08.00510.1016/j.jinf.2020.08.005741150532771402Search in Google Scholar

Armstrong-James D. Invasive Candida species infection: the importance of adequate empirical antifungal therapy. Antimicrob Chemother. 2007 Sep;60(3):459–460. https://doi.org/10.1093/jac/dkm260Armstrong-JamesD. Invasive Candida species infection: the importance of adequate empirical antifungal therapy. Antimicrob Chemother. 2007Sep;60(3):459–460. https://doi.org/10.1093/jac/dkm26010.1093/jac/dkm26017646200Search in Google Scholar

Bader MS, Lai SM, Kumar V, Hinthorn D. Candidemia in patients with diabetes mellitus: epidemiology and predictors of mortality. Scand J Infect Dis. 2004;36(11–12):860–864. https://doi.org/10.1080/00365540410021126BaderMSLaiSMKumarVHinthornD. Candidemia in patients with diabetes mellitus: epidemiology and predictors of mortality. Scand J Infect Dis. 2004;36(11–12):860–864. https://doi.org/10.1080/0036554041002112610.1080/0036554041002112615764174Search in Google Scholar

Beović B, Doušak M, Ferreira-Coimbra J, Nadrah K, Rubulotta F, Belliato M, Berger-Estilita J, Ayoade F, Rello J, Erdem H. Antibiotic use in patients with COVID-19: a ‘snapshot’ Infectious Diseases International Research Initiative (ID-IRI) survey. J Antimicrob Chemother. 2020 Nov 1;75(11):3386–3390. https://doi.org/10.1093/jac/dkaa326BeovićBDoušakMFerreira-CoimbraJNadrahKRubulottaFBelliatoMBerger-EstilitaJAyoadeFRelloJErdemH. Antibiotic use in patients with COVID-19: a ‘snapshot’ Infectious Diseases International Research Initiative (ID-IRI) survey. J Antimicrob Chemother. 2020Nov1;75(11):3386–3390. https://doi.org/10.1093/jac/dkaa32610.1093/jac/dkaa326745456332766706Search in Google Scholar

Cortés JA, Montañez AM, Carreño-Gutiérrez AM, Reyes P, Gómez CH, Pescador A, Ariza B, Rosso F. Risk factors for mortality in Colombian patients with candidemia. J Fungi (Basel). 2021 May 31;7(6):442. https://doi.org/10.3390/jof7060442CortésJAMontañezAMCarreño-GutiérrezAMReyesPGómezCHPescadorAArizaBRossoF. Risk factors for mortality in Colombian patients with candidemia. J Fungi (Basel). 2021May31;7(6):442. https://doi.org/10.3390/jof706044210.3390/jof7060442822979434073125Search in Google Scholar

Dupont D, Menotti J, Turc J, Miossec C, Wallet F, Richard JC, Argaud L, Paulus S, Wallon M, Ader F, et al. Pulmonary aspergillosis in critically ill patients with Coronavirus Disease 2019 (COVID-19). Med Mycol. 2021 Jan 4;59(1):110–114. https://doi.org/10.1093/mmy/myaa078DupontDMenottiJTurcJMiossecCWalletFRichardJCArgaudLPaulusSWallonMAderF. Pulmonary aspergillosis in critically ill patients with Coronavirus Disease 2019 (COVID-19). Med Mycol. 2021Jan4;59(1):110–114. https://doi.org/10.1093/mmy/myaa07810.1093/mmy/myaa078749974832914189Search in Google Scholar

Falagas ME, Apostolou KE, Pappas VD. Attributable mortality of candidemia: a systematic review of matched cohort and case-control studies. Eur J Clin Microbiol Infect Dis. 2006 Jul;25(7):419–425. https://doi.org/10.1007/s10096-006-0159-2FalagasMEApostolouKEPappasVD. Attributable mortality of candidemia: a systematic review of matched cohort and case-control studies. Eur J Clin Microbiol Infect Dis. 2006Jul;25(7):419–425. https://doi.org/10.1007/s10096-006-0159-210.1007/s10096-006-0159-216773391Search in Google Scholar

Gudlaugsson O, Gillespie S, Lee K, Vande Berg J, Hu J, Messer S, Herwaldt L, Pfaller M, Diekema D. Attributable mortality of nosocomial candidemia, revisited. Clin Infect Dis. 2003 Nov 1;37(9): 1172–1177. https://doi.org/10.1086/378745GudlaugssonOGillespieSLeeKVande BergJHuJMesserSHerwaldtLPfallerMDiekemaD. Attributable mortality of nosocomial candidemia, revisited. Clin Infect Dis. 2003Nov1;37(9): 1172–1177. https://doi.org/10.1086/37874510.1086/37874514557960Search in Google Scholar

Hassan I, Powell G, Sidhu M, Hart WM, Denning DW. Excess mortality, length of stay and cost attributable to candidaemia. Infect. 2009 Nov;59(5):360–365. https://doi.org/10.1016/j.jinf.2009.08.020HassanIPowellGSidhuMHartWMDenningDW. Excess mortality, length of stay and cost attributable to candidaemia. Infect. 2009Nov;59(5):360–365. https://doi.org/10.1016/j.jinf.2009.08.02010.1016/j.jinf.2009.08.02019744519Search in Google Scholar

Horan TC, Andrus M, Dudeck MA. CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Am J Infect Control. 2008 Jun;36(5):309–332. https://doi.org/10.1016/j.ajic.2008.03.002HoranTCAndrusMDudeckMA. CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Am J Infect Control. 2008Jun;36(5):309–332. https://doi.org/10.1016/j.ajic.2008.03.00210.1016/j.ajic.2008.03.00218538699Search in Google Scholar

Kaur H, Chakrabarti A. Strategies to reduce mortality in adult and neonatal candidemia in developing countries. J Fungi (Basel). 2017 Jul 19;3(3):41. https://doi.org/10.3390/jof3030041KaurHChakrabartiA. Strategies to reduce mortality in adult and neonatal candidemia in developing countries. J Fungi (Basel). 2017Jul19;3(3):41. https://doi.org/10.3390/jof303004110.3390/jof3030041571594229371558Search in Google Scholar

Lai CC, Shih TP, Ko WC, Tang HJ, Hsueh PR. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges. Int J Antimicrob Agents. 2020 Mar;55(3):105924. https://doi.org/10.1016/j.ijantimicag.2020.105924LaiCCShihTPKoWCTangHJHsuehPR. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges. Int J Antimicrob Agents. 2020Mar;55(3):105924. https://doi.org/10.1016/j.ijantimicag.2020.10592410.1016/j.ijantimicag.2020.105924712780032081636Search in Google Scholar

Mastrangelo A, Germinario BN, Ferrante M, Frangi C, Li Voti R, Muccini C, Ripa M; COVID-BioB Study Group. Candidemia in COVID-19 patients: incidence and characteristics in a prospective cohort compared to historical non-COVID-19 controls. Clin Infect Dis. 2020 Oct 30:ciaa1594. https://doi.org/10.1093/cid/ciaa1594MastrangeloAGerminarioBNFerranteMFrangiCLi VotiRMucciniCRipaM; COVID-BioB Study Group. Candidemia in COVID-19 patients: incidence and characteristics in a prospective cohort compared to historical non-COVID-19 controls. Clin Infect Dis. 2020Oct30:ciaa1594. https://doi.org/10.1093/cid/ciaa159410.1093/cid/ciaa1594766542333124650Search in Google Scholar

Morrell M, Fraser VJ, Kollef MH. Delaying the empiric treatment of Candida bloodstream infection until positive blood culture results are obtained: a potential risk factor for hospital mortality. Antimicrob Agents Chemother. 2005 Sep;49(9):3640–3645. https://doi.org/10.1128/AAC.49.9.3640-3645.2005MorrellMFraserVJKollefMH. Delaying the empiric treatment of Candida bloodstream infection until positive blood culture results are obtained: a potential risk factor for hospital mortality. Antimicrob Agents Chemother. 2005Sep;49(9):3640–3645. https://doi.org/10.1128/AAC.49.9.3640-3645.200510.1128/AAC.49.9.3640-3645.2005119542816127033Search in Google Scholar

Nori P, Cowman K, Chen V, Bartash R, Szymczak W, Madaline T, Punjabi Katiyar C, Jain R, Aldrich M, Weston G, et al. Bacterial and fungal coinfections in COVID-19 patients hospitalized during the New York City pandemic surge. Infect Control Hosp Epidemiol. 2021 Jan;42(1):84–88. https://doi.org/10.1017/ice.2020.368NoriPCowmanKChenVBartashRSzymczakWMadalineTPunjabi KatiyarCJainRAldrichMWestonG. Bacterial and fungal coinfections in COVID-19 patients hospitalized during the New York City pandemic surge. Infect Control Hosp Epidemiol. 2021Jan;42(1):84–88. https://doi.org/10.1017/ice.2020.36810.1017/ice.2020.368741797932703320Search in Google Scholar

Nucci M, Barreiros G, Guimarães LF, Deriquehem VAS, Castiñeiras AC, Nouér SA. Increased incidence of candidemia in a tertiary care hospital with the COVID-19 pandemic. Mycoses. 2021 Feb;64(2):152–156. https://doi.org/10.1111/myc.13225NucciMBarreirosGGuimarãesLFDeriquehemVASCastiñeirasACNouérSA. Increased incidence of candidemia in a tertiary care hospital with the COVID-19 pandemic. Mycoses. 2021Feb;64(2):152–156. https://doi.org/10.1111/myc.1322510.1111/myc.13225775349433275821Search in Google Scholar

Obata R, Maeda T, Rizk D, Kuno T. Increased secondary infection in COVID-19 patients treated with steroids in New York City. Jpn J Infect Dis. 2021 Jul 21;74(4):307–315. https://doi.org/10.7883/yoken.JJID.2020.884ObataRMaedaTRizkDKunoT. Increased secondary infection in COVID-19 patients treated with steroids in New York City. Jpn J Infect Dis. 2021Jul21;74(4):307–315. https://doi.org/10.7883/yoken.JJID.2020.88410.7883/yoken.JJID.2020.88433390434Search in Google Scholar

Pappas PG, Kauffman CA, Andes DR, Clancy CJ, Marr KA, Ostrosky-Zeichner L, Reboli AC, Schuster MG, Vazquez JA, Walsh TJ, et al. Clinical practice guideline for the management of candidiasis: 2016 update by the Infectious Diseases Society of America. Clin Infect Dis. 2016 Feb 15;62(4):e1–e50. https://doi.org/10.1093/cid/civ933PappasPGKauffmanCAAndesDRClancyCJMarrKAOstrosky-ZeichnerLReboliACSchusterMGVazquezJAWalshTJ. Clinical practice guideline for the management of candidiasis: 2016 update by the Infectious Diseases Society of America. Clin Infect Dis. 2016Feb15;62(4):e1–e50. https://doi.org/10.1093/cid/civ93310.1093/cid/civ933472538526679628Search in Google Scholar

Patolia S, Kennedy E, Zahir M, Patolia S, Gulati N, Narendra D, Vadde R, Pokharel S, Schmidt FM, Enriquez D, et al. Risk factors for candida blood stream infection in medical ICU and role of colonization – A retrospective study. BJMP 2013;6(2):a618PatoliaSKennedyEZahirMPatoliaSGulatiNNarendraDVaddeRPokharelSSchmidtFMEnriquezD. Risk factors for candida blood stream infection in medical ICU and role of colonization – A retrospective study. BJMP2013;6(2):a618Search in Google Scholar

Rawson TM, Moore LSP, Zhu N, Ranganathan N, Skolimowska K, Gilchrist M, Satta G, Cooke G, Holmes A. Bacterial and fungal coinfection in individuals with coronavirus: a rapid review to support COVID-19 antimicrobial prescribing. Clin Infect Dis. 2020 Dec 3;71(9):2459–2468. https://doi.org/10.1093/cid/ciaa530RawsonTMMooreLSPZhuNRanganathanNSkolimowskaKGilchristMSattaGCookeGHolmesA. Bacterial and fungal coinfection in individuals with coronavirus: a rapid review to support COVID-19 antimicrobial prescribing. Clin Infect Dis. 2020Dec3;71(9):2459–2468. https://doi.org/10.1093/cid/ciaa53010.1093/cid/ciaa530719759632358954Search in Google Scholar

Rotondo JC, Oton-Gonzalez L, Mazziotta C, Lanzillotti C, Iaquinta MR, Tognon M, Martini F. Simultaneous detection and viral DNA load quantification of different human papillomavirus types in clinical specimens by the high analytical droplet digital PCR method. Front Microbiol. 2020 Nov 19;11:591452. https://doi.org/10.3389/fmicb.2020.591452RotondoJCOton-GonzalezLMazziottaCLanzillottiCIaquintaMRTognonMMartiniF. Simultaneous detection and viral DNA load quantification of different human papillomavirus types in clinical specimens by the high analytical droplet digital PCR method. Front Microbiol. 2020Nov19;11:591452. https://doi.org/10.3389/fmicb.2020.59145210.3389/fmicb.2020.591452771052233329471Search in Google Scholar

Sarı S, Dal HC, Mungan İ, Tezcan B, Kazancı D, Turan S. [Retrospective evaluation of non-neutropenic candidemia cases in intensive care units] (in Turkish). J Medical Surg Intensive Care Med. 2018;9(3): 74–77. https://doi.org/10.5152/dcbybd.2018.1799SarıSDalHCMunganİTezcanBKazancıDTuranS. [Retrospective evaluation of non-neutropenic candidemia cases in intensive care units] (in Turkish). J Medical Surg Intensive Care Med. 2018;9(3): 74–77. https://doi.org/10.5152/dcbybd.2018.179910.5152/dcbybd.2018.1799Search in Google Scholar

Schauwvlieghe AFAD, Rijnders BJA, Philips N, Verwijs R, Vanderbeke L, Van Tienen C, Lagrou K, Verweij PE, Van de Veerdonk FL, Gommers D, et al.; Dutch-Belgian Mycosis study group. Invasive aspergillosis in patients admitted to the intensive care unit with severe influenza: a retrospective cohort study. Lancet Respir Med. 2018 Oct;6(10):782–792. https://doi.org/10.1016/S2213-2600(18)30274-1SchauwvliegheAFADRijndersBJAPhilipsNVerwijsRVanderbekeLVan TienenCLagrouKVerweijPEVan de VeerdonkFLGommersD; Dutch-Belgian Mycosis study group. Invasive aspergillosis in patients admitted to the intensive care unit with severe influenza: a retrospective cohort study. Lancet Respir Med. 2018Oct;6(10):782–792. https://doi.org/10.1016/S2213-2600(18)30274-110.1016/S2213-2600(18)30274-1Search in Google Scholar

Segrelles-Calvo G, Araújo GRS, Llopis-Pastor E, Carrillo J, Hernández-Hernández M, Rey L, Rodríguez Melean N, Escribano I, Antón E, Zamarro C, et al. Prevalence of opportunistic invasive aspergillosis in COVID-19 patients with severe pneumonia. Mycoses. 2021 Feb;64(2):144–151. https://doi.org/10.1111/myc.13219Segrelles-CalvoGAraújoGRSLlopis-PastorECarrilloJHernández-HernándezMReyLRodríguez MeleanNEscribanoIAntónEZamarroC. Prevalence of opportunistic invasive aspergillosis in COVID-19 patients with severe pneumonia. Mycoses. 2021Feb;64(2):144–151. https://doi.org/10.1111/myc.1321910.1111/myc.13219Search in Google Scholar

Tokak S, Uğurcan D, Tekindal MA. [Determination of candidemia risk factors in inpatients in adult intensive care unit] (in Turkish). FLORA 2020;25(1):47–53. https://doi.org/10.5578/flora.68473TokakSUğurcanDTekindalMA. [Determination of candidemia risk factors in inpatients in adult intensive care unit] (in Turkish). FLORA2020;25(1):47–53. https://doi.org/10.5578/flora.6847310.5578/flora.68473Search in Google Scholar

White PL, Dhillon R, Healy B, Wise MP, Backs M. Candidaemia in COVID-19, a link to disease pathology or increased clinical pressures? Clin Infect Dis. 2020 Oct 18:ciaa1597. https://doi.org/10.1093/cid/ciaa1597WhitePLDhillonRHealyBWiseMPBacksM. Candidaemia in COVID-19, a link to disease pathology or increased clinical pressures?Clin Infect Dis. 2020Oct18:ciaa1597. https://doi.org/10.1093/cid/ciaa159710.1093/cid/ciaa1597Search in Google Scholar

WHO. Clinical management of COVID-19: interim guidance, 27 May 2020 (No. WHO/2019-nCoV/clinical/2020.5) [Internet]. Geneva (Switzerland): World Health Organization; 2020 [cited 2021 May 17]. Available from https://apps.who.int/iris/handle/10665/332196WHO. Clinical management of COVID-19: interim guidance, 27 May 2020 (No. WHO/2019-nCoV/clinical/2020.5) [Internet]. Geneva (Switzerland): World Health Organization; 2020[cited 2021 May 17]. Available from https://apps.who.int/iris/handle/10665/332196Search in Google Scholar

Yang X, Yu Y, Xu J, Shu H, Xia J, Liu H, Wu Y, Zhang L, Yu Z, Fang M, et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med. 2020 May; 8(5):475–481. https://doi.org/10.1016/S2213-2600(20)30079-5YangXYuYXuJShuHXiaJLiuHWuYZhangLYuZFangM. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med. 2020May; 8(5):475–481. https://doi.org/10.1016/S2213-2600(20)30079-510.1016/S2213-2600(20)30079-5Search in Google Scholar

Zaoutis TE, Argon J, Chu J, Berlin JA, Walsh TJ, Feudtner C. The epidemiology and attributable outcomes of candidemia in adults and children hospitalized in the United States: a propensity analysis. Clin Infect Dis. 2005 Nov 1;41(9):1232–1239. https://doi.org/10.1086/496922ZaoutisTEArgonJChuJBerlinJAWalshTJFeudtnerC. The epidemiology and attributable outcomes of candidemia in adults and children hospitalized in the United States: a propensity analysis. Clin Infect Dis. 2005Nov1;41(9):1232–1239. https://doi.org/10.1086/49692210.1086/49692216206095Search in Google Scholar