Occurrence of Beta-Lactamases in Colistin-Resistant Enterobacterales Strains in Poland – a Pilot Study
, , , oraz | 06 gru 2021
O artykule
Article Category: short-communication
Data publikacji: 06 gru 2021
Zakres stron: 283 - 288
Otrzymano: 19 lut 2021
Przyjęty: 10 maj 2021
DOI: https://doi.org/10.33073/pjm-2021-021
Słowa kluczowe
© 2021 Elżbieta M. Stefaniuk et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Susceptibility of colistin-resistant Enterobacterales strains (n = 65) to ceftazidime, ceftazidime/avibactam, imipenem, meropenem, and meropenem/vaborbactam.
| Strains (n; %) | Colistin | CAZ | CAZ/AVB | IPM | MEM | MEM/VB | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MIC (mg/l) | S | R | S | R | S | I | R | S | I | R | S | R | |||
| Value | Numer of isolates | ||||||||||||||
| 4 | 11 | 0 | 0 | 11 | 9 | 2 | 9 | 0 | 2 | 9 | 1 | 1 | 10 | 1 | |
| 8 | 4 | 0 | 4 | 0 | 4 | 0 | 4 | 0 | 0 | 4 | 0 | 0 | 4 | 0 | |
| 16 | 2 | 0 | 0 | 2 | 1 | 0 | 2 | 0 | 0 | 2 | 0 | 0 | 2 | 0 | |
| 32 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | |
| 64 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | |
| > 64 | 26 | 0 | 14 | 12 | 24 | 2 | 19 | 1 | 6 | 19 | 2 | 5 | 23 | 3 | |
| 4 | 4 | 0 | 2 | 2 | 4 | 0 | 4 | 0 | 0 | 4 | 0 | 0 | 4 | 0 | |
| 8 | 5 | 0 | 3 | 2 | 5 | 0 | 5 | 0 | 0 | 5 | 0 | 0 | 5 | 0 | |
| 16 | 3 | 1 | 0 | 3 | 3 | 0 | 3 | 0 | 0 | 3 | 0 | 0 | 3 | 0 | |
| 32 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | |
| 64 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | |
| > 64 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | |
| 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| 8 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | |
| 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| 32 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| 64 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| > 64 | 2 | 0 | 1 | 1 | 2 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 2 | 0 | |
| 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| 16 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | |
| 32 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| 64 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| > 64 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | |
| Total | 65 | 3 | 28 | 37 | 59 | 6 | 52 | 3 | 10 | 53 | 5 | 7 | 61 | 4 | |
Presence of selected ESBLs and carbapenemases among colistin-resistant Enterobacterales strains (n = 65*).
| Strains (n; %) | Colistin | Types of ESBLs | Types of carbapenemases | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| MIC (mg/l) | CTX-M-1 | CTX-M-9 | TEM | SHV | KPC | NDM | OXA-48 | |||
| Value | Number of isolates | |||||||||
| 4 | 11 | 0 | 6 | 1 | 2 | 0 | 0 | 2 | 0 | |
| 8 | 4 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | |
| 16 | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | |
| 32 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| 64 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| > 64 | 26 | 0 | 22 | 1 | 3 | 4 | 1 | 3 | 1 | |
| 4 | 4 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | |
| 8 | 5 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | |
| 16 | 3 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | |
| 64 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | |
| 8 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| > 64 | 2 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | |
| Total | 61 | 3 | 41 | 2 | 10 | 5 | 1 | 5 | 2 | |