<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Oxidative stress-induced series of related degenerative diseases have received widespread attention. To screen new lactic acid bacteria (LAB) strains to resist oxidative stress, traditional Chinese fermented vegetables were used as a resource library to screen of LAB. The <italic>Lactobacillus fermentum</italic> JX306 strain, which showed high scavenging activity of DPPH free radical and hydrogen radical, and a strong lipid peroxidation inhibition rate <italic>in vitro</italic> was selected. <italic>L. fermentum</italic> JX306 was also examined for its antioxidant capacity in D-galactose-induced aging mice. The results showed that <italic>L. fermentum</italic> JX306 could significantly decrease malondialdehyde (MDA) levels and improve the activity of glutathione peroxidase (GSH-Px), and total antioxygenic capacity (TOC) in the serum, kidney, and liver. Meanwhile, the strain could remarkably upregulate the transcriptional level of the antioxidant-related enzyme genes, such as peroxiredoxin1 (Prdx1), glutathione reductase (Gsr), glutathione peroxidase (Gpx1), and thioredoxin reductase (TR3) encoding genes in the liver. Besides, histopathological observation proves that this probiotic strain could effectively inhibit oxidative damage to the liver and kidney in aging mice. Therefore, this unique antioxidant strain may have a high application value in the functional food industry and medicine industry.</p>
</abstract>

Oxidative stress-induced series of related degenerative diseases have received widespread attention. To screen new lactic acid bacteria (LAB) strains to resist oxidative stress, traditional Chinese fermented vegetables were used as a resource library to screen of LAB. The Lactobacillus fermentum JX306 strain, which showed high scavenging activity of DPPH free radical and hydrogen radical, and a strong lipid peroxidation inhibition rate in vitro was selected. L. fermentum JX306 was also examined for its antioxidant capacity in D-galactose-induced aging mice. The results showed that L. fermentum JX306 could significantly decrease malondialdehyde (MDA) levels and improve the activity of glutathione peroxidase (GSH-Px), and total antioxygenic capacity (TOC) in the serum, kidney, and liver. Meanwhile, the strain could remarkably upregulate the transcriptional level of the antioxidant-related enzyme genes, such as peroxiredoxin1 (Prdx1), glutathione reductase (Gsr), glutathione peroxidase (Gpx1), and thioredoxin reductase (TR3) encoding genes in the liver. Besides, histopathological observation proves that this probiotic strain could effectively inhibit oxidative damage to the liver and kidney in aging mice. Therefore, this unique antioxidant strain may have a high application value in the functional food industry and medicine industry.


<italic>Lactobacillus fermentum</italic> JX306 Restrain D-galactose-induced Oxidative Stress of Mice through its Antioxidant Activity

Polish Journal of Microbiology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.


 JX306 Restrain D-galactose-induced Oxidative Stress of Mice through its Antioxidant Activity

Oxidative stress-induced series of related degenerative diseases have received widespread attention. To screen new lactic acid bacteria (LAB) strains to resist...

Lactobacillus fermentum JX306 Restrain D-galactose-induced Oxidative Stress of Mice through its Antioxidant Activity

Article Category: original-paper

Data publikacji: 04 cze 2020

Zakres stron: 205 - 215

Otrzymano: 14 lut 2020

Przyjęty: 21 kwi 2020

DOI: https://doi.org/10.33073/pjm-2020-024

Słowa kluczowe
lactic acid bacteria, antioxidant activity, traditional Chinese fermented vegetables, D-galactose-induced aging mice

© 2020 Di Zhang et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Lactobacillus fermentum JX306 Restrain D-galactose-induced Oxidative Stress of Mice through its Antioxidant Activity

Article Category: original-paper

Data publikacji: 04 cze 2020

Zakres stron: 205 - 215

Otrzymano: 14 lut 2020

Przyjęty: 21 kwi 2020

DOI: https://doi.org/10.33073/pjm-2020-024

Słowa kluczowelactic acid bacteria, antioxidant activity, traditional Chinese fermented vegetables, D-galactose-induced aging mice

© 2020 Di Zhang et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Słowa kluczowe
lactic acid bacteria, antioxidant activity, traditional Chinese fermented vegetables, D-galactose-induced aging mice