<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>This problem - solving article considers positive and negative non-analgesic actions of local anaesthetics, which may play a significant role in patient morbidity and mortality. Direct impact on inflammatory and immune substances and cells leads to antibacterial, anti-inflammatory, immunomodulating and systemic functions of numerous local anaesthetics. Local anaesthetics used perioperatively locally in continuous infusions or in systemic circulation reach and maintain safe and effective rates, but myotoxic and tissue growth inhibiting effect should be taken in account.</p></abstract>

This problem - solving article considers positive and negative non-analgesic actions of local anaesthetics, which may play a significant role in patient morbidity and mortality. Direct impact on inflammatory and immune substances and cells leads to antibacterial, anti-inflammatory, immunomodulating and systemic functions of numerous local anaesthetics. Local anaesthetics used perioperatively locally in continuous infusions or in systemic circulation reach and maintain safe and effective rates, but myotoxic and tissue growth inhibiting effect should be taken in account.

Local Anaesthetics: What Can We Expect More than Pain Relief?

Hospital of Traumatology and Orthopaedics, Riga, Latvia

Research Laboratory of Traumatology and Orthopaedics, Riga Stradins Univesity, Latvia

Department of Anaesthesiology and Reanimatology, Riga Stradins University, Latvia

Acta Chirurgica Latviensis

{"article-title":"Local Anaesthetics: What Can We Expect More than Pain Relief?"}

This problem - solving article considers positive and negative non-analgesic actions of local anaesthetics, which may play a significant role in patient...

Local Anaesthetics: What Can We Expect More than Pain Relief?

Data publikacji: 18 sie 2010

Zakres stron: 100 - 104

DOI: https://doi.org/10.2478/v10163-010-0020-7

Słowa kluczowe
anti-inflammatory, immune response, local anaesthetics, systemic analgesia

This content is open access.

Local Anaesthetics: What Can We Expect More than Pain Relief?

Data publikacji: 18 sie 2010

Zakres stron: 100 - 104

DOI: https://doi.org/10.2478/v10163-010-0020-7

Słowa kluczoweanti-inflammatory, immune response, local anaesthetics, systemic analgesia

This content is open access.

Słowa kluczowe
anti-inflammatory, immune response, local anaesthetics, systemic analgesia