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Toxicological aspects of the use of phenolic compounds in disease prevention


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Agte V and Tarwadi K. (2010). The importance of nutrition in the prevention of ocular disease with special reference to cataract. Ophthalmic Res 44(3): 166-172.Search in Google Scholar

Ahmad A, Asad SF, Singh S and Hadi SM. (2000). DNA breakage by resveratrol and Cu(II): reaction mechanism and bacteriophage inactivation. Cancer Lett 154: 29-37.Search in Google Scholar

Angelone T, Pasqua T, Di Majo D, Quintieri AM, Filice E, Amodio N, Tota B, Giammanco M and Cerra MC. (2010). Distinct signalling mechanisms are involved in the dissimilar myocardial and coronary effects elicited by quercetin and myricetin, two red wine flavonols. Nutr Metab Cardiovasc Dis 21(5): 362-371.Search in Google Scholar

Baraldo M. (2008). The influence of circadian rhytms on the kinetics of drugs in humans. Expert Opin Drug Metab Toxicol 4(2): 175-192.Search in Google Scholar

Barjesteh van Waalwijk van Doorn-Khosrovani S, Janssen J, Maas LM, Godschalk RW, Nijhuis JG and Schooten FJ. (2007). Dietary flavonoids induce MLL translocations in primary human CD34+ cells. Carcinogenesis 28: 1703-1709.10.1093/carcin/bgm102Search in Google Scholar

Bhat KPL and Pezzuto JM. (2002). Cancer chemopreventive activity of resveratrol. Ann N Y Acad Sci 957: 210-229.Search in Google Scholar

Birt DF, Hendrich S and Wang WQ. (2001). Dietary agents in cancer prevention: flavonoids and isoflavonoids. Pharmacol Ther 90: 157-177.Search in Google Scholar

Biswal SS, Datta K, Shaw SD, Feng X, Robertson JD and Kehrer JP. (2000). Glutathione oxidation and mitochondrial depolarization as mechanisms of nordihydroguaiaretic acid-induced apoptosis in lipoxygenase-deficient FL5.12 cells. Toxicol Sci 53: 77-83.Search in Google Scholar

Brazier NC, Mitchell AH and Levine MD. (2003). Understanding drug-herb interaction. Pharmacoepidemiol Drug Saf 12: 427-430.Search in Google Scholar

Brown JP. (1980). A review of the genetic effects of naturally occurring flavonoids, anthraquinones and related compounds. Mut Res 75: 243-277.Search in Google Scholar

Byrd JC, Shinn C, Waselenko JK, Fuchs EJ, Lehman TA, Nguyen PL, Flinn IW, Diehl LF, Sausville E and Grever MR. (1998). Flavopiridol induces apoptosis in chronic lymphocytic leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence on functional p53. Blood 92: 3804-3816.Search in Google Scholar

Canivenc-Lavier MC, Bentejac M, Leclerc MH, Siess MH, Latruffe N and Suschetet M. (1996). Differential effects of nonhydroxylated flavonoids as inducers of cytochrome P450 1A and 2B isozymes in rat liver. Toxicol Appl Pharmacol 136: 348-353.Search in Google Scholar

Chung LY, Cheung TC, Kong SK, Fung KP, Choy YM, Chan ZY and Kwok TT. (2001). Induction of apoptosis by green tea catechins in human prostate cancer DU145 cells. Life Sci 68: 1207-1214.Search in Google Scholar

Colalto C. (2010). Herbal interactions on absorption of drugs: Mechanisms of action and clinical risk assessment. Pharmacol Res 62: 207-227.Search in Google Scholar

Cos P, De Bruyne T, Apers S, Vanden Berghe D, Pieters L and Vlietinck AJ. (2003). Phytoestrogens: recent developments. Planta Med 69: 589-599.Search in Google Scholar

Crozier A, Del Rio D and Clifford MN. (2010). Bioavailability of dietary flavonoids and phenolic compounds. Mol Aspects Med 31(6): 446-467.Search in Google Scholar

Csokay B, Prajda N, Weber G and Olah E. (1997). Molecular mechanisms in the antiproliferative action of quercetin. Life Sci 60: 2157-2163.Search in Google Scholar

Cvorovic J, Tramer F, Granzotto M, Candussio L, Decorti G and Passamonti S. (2010). Oxidative stress-based cytotoxicity of delphinidin and cyanidin in colon cancer cells. Arch Biochem Biophys 501: 151-157.Search in Google Scholar

Decker EA. (1997). Phenolics: pro-oxidants or antioxidants? Nutr Rev 55: 396-407.10.1111/j.1753-4887.1997.tb01580.xSearch in Google Scholar

Degli Esposti M. (1998). Inhibitors of NADH-ubiquinone reductase: an over-view. Biochim Biophys Acta 1364: 222-235.Search in Google Scholar

Doostdar H, Burke MD and Mayer RT. (2000). Bioflavonoids: selective substrates and inhibitors for cytochrome P450 CYP1A and CYP1B1. Toxicology 144: 31-38.Search in Google Scholar

Duffy C, Perez K and Partridge A. (2007). Implications of phytoestrogen intake for breast cancer. CA Can J Clin 57: 260-277.Search in Google Scholar

Dunnick JK and Hailey JR. (1992). Toxicity and carcinogenicity studies of quercetin, a natural component of foods. Fundam Appl Toxicol 19: 423-431.Search in Google Scholar

Duthie GG, Gardner PT and Kyle JA. (2003). Plant polyphenols: are they the new magic bullet? Proc Nutr Soc 62: 599-603.10.1079/PNS2003275Search in Google Scholar

EMEA Commitee on Herbal Medicinal Products. (2006). Guideline on the assessment of clinical safety and efficacy in the preparation of community herbal monographs for well-estabilished and of community herbal monographs/entries to the community list for traditional herbal medicinal products/substances/preparations. Avaible from: http://www.emea.europa.eu/pdfs/human/hmpc/10461305en.pdfSearch in Google Scholar

Fang N and Casida JE. (1998). Anticancer action of cube insecticide: correlation for rotenoid constituents between inhibition of NADH: ubiquinone oxidoreductase and induced ornithine decarboxylase activities. Proc Natl Acad Sci USA 95: 3380-3384.Search in Google Scholar

Feng R, Ni HM, Wang SY, Tourkova IL, Shurin MR, Harada H and Yin XM. (2007). Cyanidin-3-rutinoside, a natural polyphenol antioxidant, selectively kills leukemic cells by induction of oxidative stress. J Biol Chem 282: 13468-13476.Search in Google Scholar

Ferguson LR and Philpott M. (2008). Nutrition and mutagenesis. Annu Rev Nutr 28: 313-329.Search in Google Scholar

Fischer PM and Lane DP. (2000). Inhibitors of cyclin-dependent kinases as anti-cancer therapeutics. Curr Med Chem 7: 1213-1245.Search in Google Scholar

Formica JV and Regelson W. (1995). Review of the biology of quercetin and related bioflavonoids. Food Chem Toxicol 33: 1061-1080.Search in Google Scholar

Fraga CG, Galleano M, Verstraeten SV and Oteiza PI. (2010). Basic biochemical mechanisms behind the health benefits of polyphenols. Mol Aspects Med 31: 435-445.Search in Google Scholar

Franconi F, Brunelleschi S, Steardo L and Cuomo V. (2007). Gender differences in drug responses. Pharmacol Res 55(2): 81-95.Search in Google Scholar

Fuhr U. (1998). Drug interactions with grapefruit juice. Extent, probablemechanism and clinical relevance. Drug Saf 18(4): 251-272.Search in Google Scholar

Furukawa A, Oikawa S, Murata M, Hiraku Y and Kawanishi S. (2003). (_)-Epigallocatechin gallate causes oxidative damage to isolated and cellular DNA. Biochem Pharmacol 66: 1769-1778.Search in Google Scholar

Galati G and O'Brien PJ. (2004). Potential toxicity of flavonoids and other dietary phenolics: significance for their chemopreventive and anticancer properties. Free Radic Biol Med 37(3): 287-303.Search in Google Scholar

Galati G, Sabzevari O, Wilson JX and O'Brien PJ. (2002). Pro-oxidant activity and cellular effects of the phenoxyl radicals of dietary flavonoids and other polyphenolics. Toxicology 177: 91-104.Search in Google Scholar

Gerwirtz DA. (1991). Does bulk damage to DNA explain the cytostatic and cytotoxic effects of topoisomerase II inhibitors? Biochem Pharmacol 42: 2253-2258.10.1016/0006-2952(91)90227-VSearch in Google Scholar

Ghosh D and Konishi T. (2007). Anthocyanins and anthocyanin-rich extracts: role in diabetes and eye function. Asia Pac J Clin Nutr 16(2): 200-208.Search in Google Scholar

Gill WB. (1988). Effects on human males of in utero exposure to exogenous sex hormones, in Toxicity of hormones in perinatal life (Mori T and Nagasawa H eds) pp. 161-177, CRC, Boca Raton, FL.Search in Google Scholar

Goldstein JC, Waterhouse P, Juin P, Evan GI and Green DR. (2000). The coordinate release of cytochrome c is rapid, complete, and kinetically invariant. Nat Cell Biol 2: 156-162.Search in Google Scholar

Guarrera S, Sacerdote C, Fiorini L, Marsala R, Polidoro S, Gamberini S, Saletta F, Malaveille C, Talaska G, Vineis P and Matullo G. (2007). Expression of DNA repair and metabolic genes in response to a flavonoid-rich diet. Br J Nutr 98: 525-533.Search in Google Scholar

Guengerich FP, Shimada T, Yun CH, Yamazaki H, Raney KD, Their R, Coles B and Harris TM. (1994). Interactions of ingested food, beverage, and tobacco components involving human cytochrome P4501A2, 2A6, 2E1, and 3A4 enzymes. Environ Health Perspect 102: 49-53.Search in Google Scholar

Hadi SM, Asad SF, Singh S and Ahmad A. (2000). Putative mechanism for anticancer and apoptosis-inducing properties of plantderived polyphenolic compounds. IUBMB Life 50: 167-171.Search in Google Scholar

Halliwell B. (2007). Dietary polyphenols: good, bad, or indifferent for your health? Cardiovasc Res 73: 341-347.10.1016/j.cardiores.2006.10.004Search in Google Scholar

Halliwell B. (2008). Are polyphenols antioxidants or pro-oxidants? What do we learn from cell culture and in vivo studies? Arch Biochem Biophys 476(2): 107-112.10.1016/j.abb.2008.01.028Search in Google Scholar

Halliwell B. (2009). The wanderings of a free radical. Free Radic Biol Med 46: 531-542.Search in Google Scholar

Hirose M, Fukushima S, Sakata T, Inui M and Ito N. (1983). Effect of quercetin on two-stage carcinogenesis of the rat urinary bladder. Cancer Lett 21: 23-27.Search in Google Scholar

Hodek P, Hanustiak P, Krizkova J, Mikelova R, Krizkova S, Stiborova M, Trnkova L, Horna A, Beklova M and Kizek R. (2006). Toxicological aspects of flavonoid interaction with biomacromolecules. Neuro Endocrinol Lett 27(Suppl 2): 14-17.Search in Google Scholar

Hodek P, Trefil P and Stiborova M. (2002). Flavonoids—potent and versatile biologically active compounds interacting with cytochromes P450. Chem Biol Interact 139: 1-21.Search in Google Scholar

Hou DX, Ose T, Lin S, Harazoro K, Imamura I, Kubo M, Uto T, Terahara N, Yoshimoto M and Fujii M. (2003). Anthocyanidins induce apoptosis in human promyelocytic leukemia cells: structure-activity relationship and mechanisms involved. Int J Oncol 23: 705-712.Search in Google Scholar

Huang YT, Hwang JJ, Lee PP, Ke FC, Huang JH, Huang CJ, Kandaswami C, Middleton EJr and Lee MT. (1999). Effects of luteolin and quercetin, inhibitors of tyrosine kinase, on cell growth and metastasis-associated properties in A431 cells overexpressing epidermal growth factor receptor. Br J Pharmacol 128: 999-1010.Search in Google Scholar

Ibrahim AR and Abul-Hajj YJ. (1990). Aromatase inhibition by flavonoids. J Steroid Biochem Mol Biol 37: 257-260.Search in Google Scholar

Ito N, Hagiwara A, Tamano S, Kagawa M, Shibata MA, Kurata Y and Fukushima S. (1989). Lack of carcinogenicity of quercetin in F334/DuCrj rats. Jpn J Cancer Res 80: 317-325.Search in Google Scholar

Izzo AA and Ernst E. (2001). Interactions between herbal medicines and prescribed drugs: a systematic review. Drugs 61(15): 2163-2175.Search in Google Scholar

Jaganatah IB and Crozier A. (2010). Dietary flavonoids and phenolic compounds, in Plant Phenolics and Human Health (Fraga CG ed), pp. 1-50, John Wiley & Sons Inc., Hoboken, NJ.Search in Google Scholar

Jaganathan SK and Mandal M. (2009). Antiproliferative effects of honey and of its polyphenols: a review. J Biomed Biotechnol 2009: 830616.Search in Google Scholar

Kalt W, Hanneken A, Milbury P and Tremblay F. (2010). Recent research on polyphenolics in vision and eye health. J Agric Food Chem 58: 4001-4007.Search in Google Scholar

Katdare M, Jinno H, Osborne MP and Telang NT. (1999). Negative growth regulation of oncogene-transformed human breast epithelial cells by phytochemicals: role of apoptosis. Ann N Y Acad Sci 889: 247-252.Search in Google Scholar

Kellis JT and Vickery LE. (1984). Inhibition of human estrogen synthetase (aromatase) by flavones. Science 225: 1032-1034.Search in Google Scholar

Kim JS, He L and Lemasters JJ. (2003). Mitochondrial permeability transition: a common pathway to necrosis and apoptosis. Biochem Biophys Res Commun 304: 463-470.Search in Google Scholar

Klejdus B, Mikelova R, Petrlova J, Potesil D, Adam V, Stiborova M, Hodek P, Vacek J, Kizek R and Kuban V. (2005). Evaluation of isoflavone aglycon and glycoside distribution in soy plants and soybeans by fast column high-performance liquid chromatography coupled with a diode-array detector. J Agric Food Chem 53: 5848-5852.Search in Google Scholar

Knekt P, Kumpulainen J, Järvinen R, Rissanen H, Heliövaara M, Reunanen A, Hakulinen T and Aromaa A. (2002). Flavonoid intake and risk of chronic diseases. Am J Clin Nutr 76(3): 560-568.Search in Google Scholar

Kohn MC, Walker NJ, Kim AH and Portier CJ. (2001). Physiological modeling of a proposed mechanism of enzyme induction by TCD. Toxicology 162: 193-208.Search in Google Scholar

Kong AN, Yu R, Chen C, Mandlekar S and Primiano T. (2000). Signal transduction events elicited by natural products: role of MAPK and caspase pathways in homeostatic response and induction of apoptosis. Arch Pharm Res 23(1): 1-16.Search in Google Scholar

Kroemer G. (2003). Mitochondrial control of apoptosis: an introduction. Biochem Biophys Res Commun 304: 433-435.Search in Google Scholar

Kuo SM. (1996). Antiproliferative potency of structurally distinct dietary flavonoids on human colon cancer cells. Cancer Lett 110: 41-48.Search in Google Scholar

Lockwood B. (2008). The beneficial effects of soy isoflavones in osteoporosis of the elderly. Elderly Nutr AgroFood Ind Hi-tech 19(5): 38-41.Search in Google Scholar

Makela S, Poutanen M, Kostian ML, Lehtimaki N Strauss L, Santti R and Vihko R. (1998). Inhibition of 17beta-hydroxysteroid oxidoreductase by flavonoids in breast and prostate cancer cells. Proc Soc Exp Biol Med 217(3): 310-316.Search in Google Scholar

Messina M and Wood CE. (2008). Soy isoflavones, estrogen therapy, and breast cancer risk: analysis and commentary. Nutr J 7(1): 17-28.Search in Google Scholar

Messina M, McCaskill-Stevens W and Lampe JW. (2006). Addressing the soy and breast cancer relatioship: review, commentary, and workshop proceedings. J Natl Can Inst 98(18): 1275-1284.Search in Google Scholar

Metodiewa D, Jaiswal AK, Cenas N, Dickancaite E and Segura-Aguilar J. (1999). Quercetin may act as a cytotoxic pro-oxidant after its metabolic activation to semiquinone and quinoidal product. Free Radic Biol Med 26(1-2): 107-116.Search in Google Scholar

Miadokova E. (2009). Isoflavonoids - an overview of their biological activities and potential health benefits. Interdiscip Toxicol 2(4): 211-218.Search in Google Scholar

Middleton E and Kandaswami C. (1994). The impact of plant flavonoids on mammalian biology: implications for immunity, inflammation and cancer, in The flavonoids: advances in research since 1986 (Harborne JB ed) pp. 619-652, Chapman & Hall, London.Search in Google Scholar

Miksicek RJ. (1995). Estrogenic flavonoids: structural requirements for biological activity. Proc Soc Exp Biol Med 208: 44-50.Search in Google Scholar

Miniello VL, Moro GE, Tarantino M, Natile M, Granieri L and Armenio L. (2003). Soy-based formulas and phyto-oestrogens: a safety profile. Acta Paediatr Suppl 91: 93-100.Search in Google Scholar

Morino K, Matsukura N, Kawachi T, Ohgaki H, Sugimura T and Hirono I. (1982). Carcinogenicity test of quercetin and rutin in golden hamsters by oral administration. Carcinogenesis 3: 93-97.Search in Google Scholar

Newbold RR, Banks EP, Bullock B and Jefferson WN. (2001). Uterine adenocarcinoma in mice treated neonatally with genistein. Cancer Res 61(11): 4325-4328.Search in Google Scholar

Ni H, Simile C, and Hardy AM. (2002). Utilization of complementary and alternative medicine by United States adults: results from the 1999 national health interview survey. Med Care 40: 353-358.Search in Google Scholar

Omiecinski CJ, Remmel RP and Hosagrahara VP. (1999). Concise review of the cytochrome P450s and their roles in toxicology. Toxicol Sci 48: 151-156.Search in Google Scholar

Oyama Y, Noguchi S, Nakata M, Okada Y, Yamazaki Y, Funai M, Chikahisa L and Kanemaru K. (1999). Exposure of rat thymocytes to hydrogen peroxide increases annexin V binding to membranes: inhibitory actions of deferoxamine and quercetin. Eur J Pharmacol 384: 47-52.Search in Google Scholar

Pamukcu AM, Yalciner S, Hatcher JF and Bryan GT. (1980). Quercetin, a rat intestinal and bladder carcinogen present in bracken fern (Pteridium aquilinum). Cancer Res 40: 3468-3472.Search in Google Scholar

Panes J, Gerritsen ME, Anderson DC, Miyasaka M and Granger DN. (1996). Apigenin inhibits tumor necrosis factor-induced intercellular adhesion molecule-1 upregulation in vivo. Microcirculation 3: 279-286.Search in Google Scholar

Paschka AG, Butler R and Young CY. (1998). Induction of apoptosis in prostate cancer cell lines by the green tea component, (_)-epigallocatechin-3-gallate. Cancer Lett 130(1-2): 1-7.Search in Google Scholar

Patil BS, Jayaprakasha GK, Chidambara Murthy KN and Vikram A. (2009). Bioactive compounds: historical perspectives, opportunities, and challenges. J Agric Food Chem 57(18): 8142-8160.Search in Google Scholar

Rahman A, Shahabuddin A, Hadi SM and Parish JH. (1990). Complexes involving quercetin, DNA and Cu(II). Carcinogenesis 11(11): 2001-2003.Search in Google Scholar

Rhone M and Basu A. (2008). Phytochemicals and age-related eye diseases. Nutr Rev 66(8): 465-472.Search in Google Scholar

Rietjens IM, Boersma MG, van der Woude H, Jeurissen SM, Schutte ME and Alink GM. (2005). Flavonoids and alkenylbenzenes: mechanisms of mutagenic action and carcinogenic risk. Mutat Res 574(1-2): 124-138.Search in Google Scholar

Rietjens IM, Huseiny WA, Boersma MG. (2011). Flavonoids and alkenylbenzenes: New concepts in bioactivation studies. Chem Biol Interact 190(1-2): 87-95.Search in Google Scholar

Rietjens IM, Slob W, Galli C and Silano V. (2008). Risk assessment of botanical preparations intended for use in food and food supplements: emerging issues. Toxicol Lett 180(2): 131-136.Search in Google Scholar

Rong Y, Yang EB, Zhang K and Mack P. (2000). Quercetin-induced apoptosis in the monoblastoid cell line U937 in vitro and the regulation of heat shock proteins expression. Anticancer Res 20: 4339-4345.Search in Google Scholar

Ross JA. (1998). Maternal diet and infant leukemia: a role for DNA topoisomerase II inhibitors? Int J Cancer 11: 26-28.10.1002/(SICI)1097-0215(1998)78:11+<26::AID-IJC8>3.0.CO;2-MSearch in Google Scholar

Ross JA and Kasum CM. (2002). Dietary flavonoids: bioavailability, metabolic effects, and safety. Annu Rev Nutr 22: 19-34.Search in Google Scholar

Ross JA, Potter JD and Robison LL. (1994). Infant leukemia, topoisomerase II inhibitors, and the MLL gene. J Natl Cancer Inst 86: 1678-1680.Search in Google Scholar

Russo M, Palumbo R, Tedesco I, Mazzarella G, Russo P, Iacomino G and Russo GL. (1999). Quercetin and anti-CD95(Fas/ Apo1) enhance apoptosis in HPBALL cell line. FEBS Lett 462: 322-328.Search in Google Scholar

Rzymowska J, Gawron A, Pawlikowska-Pawlega B, Jakubowicz-Gil J and Wojcierowski J. (1999). The effect of quercetin on induction of apoptosis. Fol Histochem Cytobiol 37: 125-126.Search in Google Scholar

Sakihama Y, Cohen MF, Grace SC and Yamasaki H. (2002). Plant phenolic antioxidant and pro-oxidant activities: phenolics-induced oxidative damage mediated by metals in plants. Toxicology 177: 67-80.Search in Google Scholar

Scalbert A and Williamson G. (2000). Dietary intake and bioavailability of polyphenols. J Nutr 130: 2073S-2085S.Search in Google Scholar

Schewe T, Steffen Y and Sies H. (2008). How do dietary flavanols improve vascular function? A position paper. Arch Biochem Biophys 476(2): 102-106.Search in Google Scholar

Schilter B, Andersson C, Anton R, Constable A, Kleiner J, O'Brien J, Renwick AG, Korver O, Smit F and Walker R. (2003). Guidance for the safety assessment of botanicals and botanical preparations for use in food and food supplements. Food Chem Toxicol 41(12): 1625-1649.Search in Google Scholar

Schroeter H, Spencer JP, Rice-Evans C and Williams RJ. (2001). Flavonoids protect neurons from oxidized low-density-lipoprotein-induced apoptosis involving c-Jun N-terminal kinase (JNK), c-Jun and caspase-3. Biochem J 358: 547-557.Search in Google Scholar

So FV, Guthrie N, Chambers AF, Moussa M and Carroll KK. (1996). Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus juices. Nutr Cancer 26: 167-181.Search in Google Scholar

Soriani M, Rice-Evans C and Tyrrell RM. (1998). Modulation of the UVA activation of haem oxygenase, collagenase and cyclooxygenase gene expression by (_)-epigallocatechin in human skin cells. FEBS Lett 439: 253-257.Search in Google Scholar

Spencer JP, Rice-Evans C and Williams RJ. (2003a). Modulation of pro-survival Akt/protein kinase B and ERK1/2 signaling cascades by quercetin and its in vivo metabolites underlie their action on neuronal viability. J Biol Chem 278(37): 34783-34793.10.1074/jbc.M305063200Search in Google Scholar

Spencer JP, Kuhnle GG, Williams RJ and Rice-Evans C. (2003b). Intracellular metabolism and bioactivity of quercetin and its in vivo metabolites. Biochem J 372: 173-181.10.1042/bj20021972Search in Google Scholar

Steiner C, Peters WH, Gallagher EP, Magee P, Rowland I and Pool-Zobel BL. (2007). Genistein protects human mammary epithelial cells from benzo(a) pyrene-7,8-dihydrodiol-9,10-epoxide and 4-hydroxy-2-nonenal genotoxicity by modulating the glutathione/glutathione S-transferase system. Carcinogenesis 28: 738-748.Search in Google Scholar

Strick R, Strissel PL, Borgers S, Smith SL and Rowley JD. (2000). Dietary bioflavonoids induce cleavage in the MLL gene and may contribute to infant leukemia. Proc Natl Acad Sci USA 97: 4794-4795.Search in Google Scholar

Surh YJ, Hurh YJ, Kang JY, Lee E, Kong G and Lee SJ. (1999). Resveratrol, an antioxidant present in red wine, induces apoptosis in human promyelocytic leukemia (HL-60) cells. Cancer Lett 140: 1-10.Search in Google Scholar

Syed DN, Afaq F, Sarfaraz S, Khan N, Kedlaya R, Setaluri V and Mukhtar H. (2008). Delphinidin inhibits cell proliferation and invasion via modulation of Met receptor phosphorylation. Toxicol Appl Pharmacol 231(1): 52-60.Search in Google Scholar

Takamura-Enya T, Ishihara J, Tahara S, Goto S, Totsuka T, Sugimura T and Wakabayashi K. (2003). Analysis of estrogenic activity of foodstuffs and cigarette smoke condensates using a yeast estrogen screening method. Food Chem Toxicol 41: 543-550.Search in Google Scholar

Talavera S, Felgines C, Texier O, Besson C, Gil-Izquierdo A, Lamaison JL and Remesy C. (2005). Anthocyanin metabolism in rats and their distribution to digestive area, kidney, and brain. J Agric Food Chem 53: 3902-3908.Search in Google Scholar

Tang DG and Porter AT. (1996). Apoptosis: a current molecular analysis. Pathol Oncol Res 2: 117-131.Search in Google Scholar

Tang W and Stearns RA. (2001). Heterotropic cooperativity of cytochrome P450 3A4 and potential drug - drug interactions. Curr Drug Metab 2: 185-198.Search in Google Scholar

Tassaneeyakul W, Birkett DJ, Veronese ME, McManus ME, Tukey RH, Quattrochi LC, Gelboin HV and Miners JO. (1993). Specificity of substrate and inhibitor probes for human cytochromes P450 1A1 and 1A2. J Pharmacol Exp Ther 265: 401-407.Search in Google Scholar

Terada T and Inui K. (2007). Gene expression and regulation of drug transporter in the intestine and kidney. Biochem Pharmacol 73: 440-449.Search in Google Scholar

Ueda S, Nakamura H, Masutani H, Sasada T, Takabayashi A, Yamaoka Y and Yodoi J. (2001). Baicalin induces apoptosis via mitochondrial pathway as pro-oxidant. Mol Pharmacol 38: 781-791.Search in Google Scholar

van der Woude H, Gliszczynska-Swiglo A, Struijs K, Smeets A, Alink GM and Rietjens IM. (2003). Biphasic modulation of cell proliferation by quercetin at concentrations physiologically relevant in humans. Cancer Lett 200: 41-47.Search in Google Scholar

Walle T, Vincent TS and Walle UK. (2003). Evidence of covalent binding of the dietary flavonoid quercetin to DNA and protein in human intestinal and hepatic cells. Biochem Pharmacol 65: 1603-1610.Search in Google Scholar

Waller CL and McKinney JD. (1995). Three-dimensional quantitative structure-activity relationships of dioxins and dioxin-like compounds: model validation and Ah receptor characterization. Chem Res Toxicol 8: 847-858.Search in Google Scholar

Wang IK, Lin-Shiau SY and Lin JK. (1999). Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells. Eur J Cancer 35: 1517-1525.Search in Google Scholar

Wang LS and Stoner GD. (2008). Anthocyanins and their role in cancer prevention. Cancer Lett 269: 281-290.Search in Google Scholar

Wang Y, Gho WM, Chan FL, Chen S and Leung LK. (2008). The red clover (Trifolium pratense) isoflavone biochanin A inhibits aromatase activity and expression. Brit J Nutr 99: 303-310.Search in Google Scholar

Wei YQ, Zhao X, Kariya Y, Fukata H, Teshigawara K and Uchida A. (1994). Induction of apoptosis by quercetin: involvement of heat shock protein. Cancer Res 54: 4952-4957.Search in Google Scholar

Wenzel U, Kuntz S, Brendel MD and Daniel H. (2000). Dietary flavone is a potent apoptosis inducer in human colon carcinoma cells. Cancer Res 60: 3823-3831.Search in Google Scholar

Williams RJ, Spencer JP and Rice-Evans C. (2004). Flavonoids: antioxidants or signalling molecules? Free Radic Biol Med 36(7): 838-849.10.1016/j.freeradbiomed.2004.01.001Search in Google Scholar

Woodward G, Kroon P, Cassidy A and Kay C. (2009). Anthocyanin stability and recovery: implications for the analysis of clinical and experimental samples. J Agric Food Chem 57: 5271-5278.Search in Google Scholar

Yamanaka A, Oda O and Nagao S. (1997). Green tea catechins such as (_)-epicatechin and (_)-epigallocatechin accelerate Cu2+-induced low density lipoprotein oxidation in propagation phase. FEBS Lett 401: 230-234.Search in Google Scholar

Yang GY, Liao J, Kim K, Yurkow EJ and Yang CS. (1998). Inhibition of growth and induction of apoptosis in human cancer cell lines by tea polyphenols. Carcinogenesis 19: 611-616.Search in Google Scholar

You L, Sar M, Bartolucci EJ, McIntyre BS and Sriperumbudur R. (2002). Modulation of mammary gland development in prepubertal male rats exposed to genistein and methoxychlor. Toxicol Sci 66: 216-225.Search in Google Scholar

Ziberna L, Lunder M, Moze S, Vanzo A, Tramer F, Passamonti S and Drevensek G. (2010). Acute cardioprotective and cardiotoxic effects of bilberry anthocyanins in ischemia-reperfusion injury: beyond concentration-dependent antioxidant activity. Cardiovasc Toxicol 10(4): 283-94.Search in Google Scholar

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