Synthesis and evaluation of 2-substituted-6-phenyl-4,5-dihydropyridazin-3(2H)-ones as potent inodilators

S. G. Lee, J. J. Kim, D. H. Kweon, Y. J. Kang, S. D. Cho, S. K. Kim and Y. J. Yoon, Recent progress in pyridazin-3(2H)-ones chemistry, Curr. Med. Chem. 8 (2004) 1463-1480; DOI: 10.2174/1385272043369818.10.2174/1385272043369818Search in Google Scholar

K. Abouzid, M. A. Hakeem, O. Khalil and Y. Maklad, Pyridazinone derivatives: design, synthesis, and in vitro vasorelaxant activity, Bioorg. Med. Chem. 16 (2008) 382-389; DOI: 10.1016/j.bmc.2007.09.03.Search in Google Scholar

K. A. M. Abou-Zeid, K. M. Youssef, M. A. Shaaban, F. A. El-Telbany and S. H. Al-Zanfaly, Synthesis of 6-(4-(substituted-amino)phenyl)-4,5-dihydropyridazin-3(2H)-ones as potential positive inotropic agents, Egypt. J. Pharm. Sci. 38 (1998) 319-331.Search in Google Scholar

T. Wang, Y. Dong, L. C. Wang and Z. Chen, Synthesis and bioactivity of 6-phenyl-4,5-dihydro-3(2H)-pyridazinone derivatives, Arzneimittelforschung 57 (2007) 641-647; DOI: 10.1002/chin. 200808160.Search in Google Scholar

C. V. Curran and A. Ross, 6-Phenyl-4,5-dihydro-3(2H)-pyridazinones. A series of hypotensive agents, J. Med. Chem. 17 (1974) 273-281; DOI: 10.1021/jm 00249a004.Search in Google Scholar

S. Archan and W. Toller, Levosimendan: current status and future prospects, Curr. Opin. Anaesthesiol. 21 (2008) 78-84; DOI: 10.1097/ACO.0b013e3282 f357a5.Search in Google Scholar

R. E. Weishaar, D. C. Kobylarz-Singer, R. P. Steffen and H. R. Kaplan, Subclasses of cyclic AMP-specific phosphodiesterase in left ventricular muscle and their involvement in regulating myocardial contractility, Circ. Res. 61 (1987) 539-547.10.1161/01.RES.61.4.5392820608Search in Google Scholar

F. F. Owings, M. Fox, C. J. Kowalski and N. H. Baine, An enantioselective synthesis of SK&F 93505, a key intermediate for preparing cardiotonic agents, J. Org. Chem. 56 (1991) 1963-1966.10.1021/jo00005a060Search in Google Scholar

B. S. Furniss, A. J. Hannaford, P. W. G. Smith and A. R. Tatchell, Aromatic Compounds, in Vogel's Text Book of Practical Organic Chemistry, 5^th ed. (Ed. A. I. Vogel), Longman Group Ltd, Harlow 1989, pp. 824-1195.Search in Google Scholar

L. G. Sevillano, C. P. Melero, E. Caballero, F. Tomé, L. Lelièvre, K. Geering, G. Crambert, R. Carrón, M. Medarde and A. San Feliciano, Inotropic activity of hydroindenic amidinohydrazones, J. Med. Chem. 45 (2002) 127-136; DOI: 10.1021/jm0109309.10.1021/jm010930911754584Search in Google Scholar

M. Guerrero, P. Puebla, R. Carrón, M. L. Martín and L. San Román, Vasorelaxant effect of new neo-clerodane diterpenoids isolated from Croton schiedeanus, J. Ethnopharmacol. 94 (2004) 185-198; DOI: 10.1016/j.jep. 2004.05.018.Search in Google Scholar

T. Seki, A. Kanada, T. Nakao, M. Shiraiwa, H. Asano, K. Miyazawa, T. Ishimori, N. Minami, K. Shibata and K. Yasuda, Studies on agents with vasodilator and β-blocking activities. V.¹⁾ Synthesis and pharmacological activity of the optical isomers of TZC-5665, Chem. Pharm. Bull. 46 (1998) 84-96.10.1248/cpb.46.849468640Search in Google Scholar

M. Endoh, Basic and clinical characteristics of PDE 3 inhibitors as cardiotonic agents, Cardiovasc. Drugs Ther. 21 (2007) 135-139; DOI: 10.1007/s0557-007-6029-z.Search in Google Scholar