Nutritional Factors in Central Metabolic Regulation

Acosta-Martinez, M., Levine, J.E. (2007). Regulation of Katp channel sub- unit gene expression by hyperglycemia in the mediobasal hypothalamus of female rats. Amer. J. Physiol. Endocrinol. Metab., 292, E1801-E1807.Search in Google Scholar

Benoit, S.C., Kemp, C.J., Elias, C.F., Abplanalp, W., Herman, J.P., Migrenne, S., Lefevre, A., Cruciani-Guglielmacci, C., Magnan, C., Yu, F., Niswensder, K., Irani, B.G., Holland, W.L., Clegg, D.J. (2009). Palmitic acid mediates hypothalamic insulin resistance by altering PKC-theta subcellular localization in rodents. J. Clin. Invest., 119, 2277-2589.10.1172/JCI36714273591719726875Search in Google Scholar

Blouet, C., Jo, Y., Li, X., Schwartz, G.J. (2009). Mediobasal hypothalamic leucine sensing regulates food intake through activation of a hypothala­mus-brainstem circuit. J. Neurosci., 29, 8302-8311.10.1523/JNEUROSCI.1668-09.2009274092319571121Search in Google Scholar

Blouet, C., Schwartz, G.J. (2010). Hypothalamic nutrient sensing in the con­trol of energy homeostasis. Behav. Brain Res., 209, 1-12.10.1016/j.bbr.2009.12.02420035790Search in Google Scholar

Chen, H., Simar, D., Lambert, K., Mercier, J., Morris, M.J. (2008). Maternal and postnatal overnutrition differentially impact appetite regulators and fuel metabolism. Endocrinology, 149, 5348-5356.10.1210/en.2008-058218635655Search in Google Scholar

Cheng, Y., Meng, Q., Xia, T., Wang, C., Li, H., Huang, Z., Chen, S., Xiao, F., Du, Y., Guo, F. (2010). Leucine deprivation decreases fat mass by stimula­tion of lipolysis in white adipose tissue and upregulation of uncoupling protein 1 (UCP1) in brown adipose tissue. Diabetes, 59, 17-25.10.2337/db09-0929279791819833890Search in Google Scholar

Cheng, Y., Zhang, Q., Meng, Q., Xia, T., Huang, Z., Wang, C., Liu, B., Chen, S., Xiao, F., Du, Y., Guo, F. (2011). Leucine deprivation stimulates fat loss via increasing CRH expression in the hypothalamus and activating the sympathetic nervous system. Mol. Endocrinol., 25, 1624-1635.10.1210/me.2011-0028316591121719534Search in Google Scholar

Cummmings, D.E. (2009). Endocrine mechanisms mediating remission of diabetes after gastric bypass surgery. Int. J. Obes. (London), 33 Supp 1, S33-S40.Search in Google Scholar

Drake, A.J., Reynolds, R.M. (2010). Impact of maternal obesity on offspring obesity and cardiometabolic disease risk. Reproduction, 140, 387-398.10.1530/REP-10-007720562299Search in Google Scholar

Figlewicz, D.P. (2003). Adiposity signals and food reward: Expanding the CNS roles of insulin and leptin. Amer. J. Physiol. Regul. Integr. Comp. Physiol., 284, R882-R892.10.1152/ajpregu.00602.200212626355Search in Google Scholar

Lam, T.K. Neuronal regulation of homeostasis by nutrient sensing. Nat. Med., 16, 392-395, 2010.10.1038/nm0410-39220376051Search in Google Scholar

Lam, T.K., Gutierrez-Juarez, R., Pocai, A., Rossetti, L. (2005). Regulation of blood glucose by hypothalamic pyruvate metabolism. Science, 309, 943-947.10.1126/science.111208516081739Search in Google Scholar

Lam, T.K., Schwartz, G.J., Rosetti, L. (2005). Hypothalamic sensing of fatty acids. Nat. Neurosci., 8, 579-584.10.1038/nn1456Search in Google Scholar

Levin, B.E. (2002). Glucosensing neurons: The metabolic sensors of the brain? Diabetes Nutr. Metab., 15, 274-281.Search in Google Scholar

Levin, B.E., Dunn-Meynell, A.A., Routh, V.H. (2002). CNS sensing and regulation of peripheral glucose levels. Int. Rev. Neurobiol., 51, 219-258.10.1016/S0074-7742(02)51007-2Search in Google Scholar

Morton, G.J., Gelling, R.W., Niswender, K.D., Morrison, C.D., Rhodes, C.J., Schwartz, M.W. (2005). Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons. Cell Metab., 2, 411-420.10.1016/j.cmet.2005.10.00916330326Search in Google Scholar

Nair, K.S., Schwartz, R.G., Welle, S. (1992). Leucine as a regulator of whole body and skeletal muscle protein metabolism in humans. Amer. J. Physiol., 263, E928-E934.10.1152/ajpendo.1992.263.5.E9281443126Search in Google Scholar

Obici, S., Zhang, B.B., Karkanias, G., Rossetti, L. (2002). Hypothalamic insulin signaling is required for inhibition of glucose production. Nat. Med., 8, 1376-1382.10.1038/nm1202-79812426561Search in Google Scholar

Pillot, B., Duraffourd, C., Begeot, M., Joly, A., Luquet, S., Houberdon, I., Naville, D., Vigier, M., Gautier-Stein, A., Magnan, C., Mithieux, G. (2011). Role of hypothalamic melanocortin system in adaptation of food intake to food protein increase in mice. PLoS ONE 6, e19107.10.1371/journal.pone.0019107308134221544212Search in Google Scholar

Rasoamanana, R., Darcel, N., Fromentin, G., Tome, D. (2012). Nutrient sensing and signalling by the gut. Proc. Nutr. Soc., 27, 1-10.10.1017/S002966511200011022453062Search in Google Scholar

Ross, R., Wang, P.Y., Chari, M., Lam, C.K., Caspi, L., Ono, H., Muse, E.D., Li, X., Gutierrez-Juarez, R., Light, P.E., Schwartz, G.J., Rossetti, L., Lam, T.K. (2008). Hypothalamic protein kinase C regulates glucose production. Diabetes, 57, 2061-2065.10.2337/db08-0206249469418511848Search in Google Scholar

Rother, E., Konner, A.C., Bruning, J.C. (2008). Neurocircuits integrating hormone and nutrient signaling in control of glucose metabolism. Amer. J. Physiol. Endocrinol. Metab., 294, E810-E816.10.1152/ajpendo.00685.200718285523Search in Google Scholar

Zheng, H., Lenard, N., Shin, A., Berthoud, H.R. (2009). Appetite control and energy balance regulation in the modern world: Reward-driven brain over­rides repletion signals. Int. J. Obes. (London), 33, S8-S13.10.1038/ijo.2009.65283817819528982Search in Google Scholar