Formulation design and evaluation of a self-microemulsifying drug delivery system of lovastatin

1. G. Suresh, K. Manjunath, V. Venkateswarlu and V. Satyanarayana, Preparation, characterization and in vitro and in vivo evaluation of lovastatin solid lipid nanoparticles, AAPS Pharm. Sci. Tech. 8 (2007) E162-E170; DOI: 10.1208/pt081024.Search in Google Scholar

2. S. K. Singh, P. R. P. Verma and B. Razdan, Development and characterization of a lovastatin loaded self-microemulsifying drug delivery system, Pharm. Dev. Tech. 15 (2010) 469-483; DOI: 10.3109/10837450903286537.10.3109/1083745090328653719793039Search in Google Scholar

3. M. Patel, A. Tekade, S. Gattani and S. Surana, Solubility enhancement of lovastatin by modified locust bean gum using solid dispersion techniques, AAPS Pharm. Sci. Tech. 9 (2008) 1262-1269; DOI: 10.1208/s12249-008-9171-4.10.1208/s12249-008-9171-4262826319115112Search in Google Scholar

4. A. Sule, L. Szente and F. Csempesz, Enhancement of drug solubility in supramolecular and colloidal systems, J. Pharm. Sci. 98 (2009) 484-494; DOI: 10.1002/jps.21437.10.1002/jps.2143718506803Search in Google Scholar

5. S. Kumar, K. Nagpal, S. K. Singh and D. N. Mishra, Improved bioavailability through floating microspheres of lovastatin, DARU J. Pharm. Sci. 19 (2011) 57-64.Search in Google Scholar

6. B. K. Kang, J. S. Lee, S. K. Chon, S. Y. Jeong, S. H. Yuk, G. Khang, H. B. Lee and S. H. Cho, Development of self-microemulsifying drug delivery systems (SMEDDS) for oral bioavailability enhancement of simvastatin in beagle dogs, Int. J. Pharm. 274 (2004) 65-73; DOI: 10.1016/j.ijpharm.2003.12.028.10.1016/j.ijpharm.2003.12.02815072783Search in Google Scholar

7. D. Patel and K. K. Sawant, Oral bioavailability enhancement of acyclovir by self-microemulsifying drug delivery system (SMEDDS), Drug Dev. Ind. Pharm. 33 (2007) 1318-1326; DOI: 10.1080/03639040701385527.10.1080/0363904070138552718097805Search in Google Scholar

8. A. R. Patel and P. R. Vavia, Preparation and in vivo evaluation of SMEDDS (self-microemulsifying drug delivery system) containing fenofibrate, AAPS J. 9 (2007) E344-352; DOI: 10.1208/aapsj0903041.10.1208/aapsj0903041275148618170981Search in Google Scholar

9. A. R. Dixit, S. J. Rajput and S. G. Patel, Preparation and bioavailability assessment of SMEDDS containing valsartan, AAPS Pharm. Sci. Tech. 11 (2010) 314-321; DOI: 10.1208/s12249-010-9385-0.10.1208/s12249-010-9385-0285045020182825Search in Google Scholar

10. United States Pharmacopoeia 33, National Formulary 28, USP Convention, Rockville (MD) 2010.Search in Google Scholar

11. P. E. Schurr, J. R. Schultz and T. M. Parkinson, Triton-induced hyperlipidemia in rats as an animal model for screening hypolipidemic drugs, Lipids 7 (1972) 68-74.10.1007/BF025312725013174Search in Google Scholar

12. International Conference on Harmonization Q1A(R2) Stability Testing Guidelines: Stability Testing of New Drug Substances and Products, ICH 2003.Search in Google Scholar

13. S. X. Cui, S. F. Nie, L. Li, C. G. Wang and W. S. Pan, Preparation and evaluation of self-microemulsifying drug delivery system containing vinpocetine, Drug Dev. Ind. Pharm. 35 (2009) 603-611; DOI: 10.1080/03639040802488089.10.1080/0363904080248808919040178Search in Google Scholar

14. J. Cui, B. Yu, Y. Zhao, W. Zhu, H. Li, H. Lou and G. Zhai, Enhancement of oral absorption of curcumin by self-microemulsifying drug delivery systems, Int. J. Pharm. 371 (2009) 148-155; DOI: 10.1016/j.ijpharm.2008.12.009.10.1016/j.ijpharm.2008.12.00919124065Search in Google Scholar

15. M. J. Patel, N. M. Patel, R. B. Patel and R. P. Patel, Formulation and evaluation of self-microemulsifying drug delivery system of lovastatin, Asian J. Pharm. Sci. 5 (2010) 266-275.Search in Google Scholar

16. Y. G. Bachhav and V. B. Patravale, SMEDDS of glyburide: Formulation, in vitro evaluation and stability studies, AAPS Pharm. Sci. Tech. 10 (2009) 482-487; DOI: 10.1208/s12249-009-9234-1.10.1208/s12249-009-9234-1269079719381824Search in Google Scholar

17. X. Wu, J. Xu, X. Huang and C. Wen, Self-microemulsifying drug delivery system improves curcumin dissolution and bioavailability, Drug Dev. Ind. Pharm. 37 (2011) 15-23; DOI: 10.3109/03639045.2010.489560.10.3109/03639045.2010.48956020738181Search in Google Scholar