Preliminary antifungal and cytotoxic evaluation of synthetic cycloalkyl[b]thiophene derivatives with PLS-DA analysis

Z. Puterová, A. Krutošíková and D. Végh, Gewalg reactions: synthesis, properties and applications of substituted 2-aminothiophenes, Arkivoc i (2010) 209-246.Search in Google Scholar

K. Balamurugan, S. Perumal, A. S. K. Reddy, P. Yogeeswari and D. Sriram, A facile domino protocol for the regioselective and discovery of novel 2-amino-5-arylthieno-[2,3-b]thiophenes as anti-mycobacterial agents, Tetrahedron Lett. 50 (2009) 6191-6195; DOI: 10.1016/j.tetlet.2009.08.085.10.1016/j.tetlet.2009.08.085Search in Google Scholar

I. M. I. Fakhr, M. A. A. Radwan, S. El-Batran, M. E. Omar, A. El-Salam and S. M. El-Shenawy, Synthesis and pharmacological evaluation of 2-substituted benzo[b]thiophenes as anti-inflammatory and analgesic agents, Eur. J. Med. Chem. 44 (2009) 1718-1725; DOI: 10.1016/j.ejmech.2008.02.034.10.1016/j.ejmech.2008.02.03418433939Search in Google Scholar

A. M. Isloor, B. Kalluraya and K. S. Pai, Synthesis, characterization and biological activities of some new benzo[b]thiophene derivatives, Eur. J. Med. Chem. 45 (2010) 825-830; DOI: 10.1016/j.ejmech.2009.11.015.10.1016/j.ejmech.2009.11.01519945198Search in Google Scholar

A. E. G. E. Amr, M. H. Sherif, M. G. Assy, M. A. Al-Omar and I. Raga, Antiarrhythmic, serotonin antagonist and antianxiety activities of novel substituted thiophene derivatives synthesized from 2-amino-4,5,6,7-tetrahydro-N-phenylbenzo[b]thiophene-3-carboxamide, Eur. J. Med. Chem. 45 (2010) 5935-5942; DOI: 10.1016/j.ejmech.2010.09.059.10.1016/j.ejmech.2010.09.05920950897Search in Google Scholar

M. Gütschow, L. Kuerschner, U. Neumann, M. Pietsch, R. Löser, N. Koglin and K. Eger, 2-(Diethylamino) thieno[1,3]oxazin-4-ones as stable inhibitors of human leukocyte elastaze, J. Med. Chem. 42 (1999) 5437-5447; DOI: 10.1021/jm991108w.10.1021/jm991108w10639285Search in Google Scholar

A. B. Pinkerton, T. T. Lee, T. Z. Hoffman, Y. Wang, M. Kahraman, T. G. Cook, D. Severance, T. C. Gahman, S. A. Noble, A. K. Shiau and R. I. Davis, Synthesis and SAR of thiophene containing kinesin spindle protein (KSP) inhibitors, Bioorg. Med. Chem. Lett. 17 (2007) 3562-3569; DOI: 10.1016/j.bmcl.2007.04.076.10.1016/j.bmcl.2007.04.07617498954Search in Google Scholar

L. Aurelio, C. Valant, H. Figler, B. L. Flynn, J. Linden, P. M. Sexton, A. Christopoulos and P. J. Scammells, 3- and 6-Substituted 2-amino-4,5,6,7-tethahydrothieno[2,3-c]pyridines as A1 adenosine receptor allosteric modulators and antagonists, Bioorg. Med. Chem. 17 (2009) 7353-7361; DOI: 10.1016/j.bmc.2009.08.024.10.1016/j.bmc.2009.08.024300558619751980Search in Google Scholar

F. J. B. Mendonça Jr., R. G. Lima-Neto, T. B. Oliveira, M. C. A. Lima, I. R. Pitta, S. L. Galdino, R. M. D. Cruz, R. S. A. Araújo and R. P. Neves, Synthesis and evaluation of the antifungal activity of 2-(substituted-amino)-4,5-dialkyl-thiophene-3-carbonitrile derivatives, Lat. Am. J. Pharm. 30 (2011) 1492-1499.Search in Google Scholar

A. A. Abu-Hashem, M. F. El-Shehry and F. A. Badria, Design and synthesis of novel thiophenecarbohydrazide, thienopyrazole and thienopyrimidine derivatives as antioxidant and antitumor agents, Acta Pharm. 60 (2010) 311-323; DOI: 10.2478/v10007-010-0030-y.10.2478/v10007-010-0030-y21134869Search in Google Scholar

National Committee for Clinical and Laboratory Standards: Method M27-A2, NCCLS, Wayne (PA), Villanova, Pennsylvania, USA, 2002, pp. 1-29.Search in Google Scholar

J. A. Barnett, R. W. Paire and D. Yarrow, Yeasts: Characteristics and Identification, Cambridge University Press, Cambridge 2000.Search in Google Scholar

E. L. Souza, T. L. M. Stamford, E. O. Lima and V. N. Trajano, Effectiveness of Origanum vulgare L. essential oil to inhibit the growth of food spoiling yeasts, Food Control 18 (2007) 409-413; DOI: 10.1016/j.foodcont.2005.11.008.10.1016/j.foodcont.2005.11.008Search in Google Scholar

P. J. Houghton, M. J. Howea, C. C. Lee and G. Steventon, Uses and abuses of in vitro tests in ethnopharmacology: visualizing an elephant, J. Ethnopharmacol. 110 (2007) 391-400; DOI: 10.1016/j.jep.2007.01.032.10.1016/j.jep.2007.01.03217317057Search in Google Scholar

M. R. Boyd and K. D. Paull, Some practical considerations and applications of the national cancer institute in vitro anticancer discovery screen, Drug Develop. Res. 34 (1995) 91-109; DOI: 10.1002/ddr.430340203.10.1002/ddr.430340203Search in Google Scholar

M. Kožurková, D. Sabolová, L. Janovec, J. Mikeš, J. Koval, J. Ungvarský, M. štefanišinová, P. Federočko, P. Kristian and J. Imrich, Cytotoxic activity of proflavinediureas: synthesis, antitumor, evaluation and DNA binding properties of 1',1''-(acridin-3,6-diyl)-3',3''-dialkyldiureas, Bioorg. Med. Chem. 16 (2008) 3976-3984; DOI: 10.1016/j.bmc.2008.01.026.10.1016/j.bmc.2008.01.02618258438Search in Google Scholar

N. L. Allinger, A hydrocarbon force-field utilizing V1 and V2 torsional terms, J. Am. Chem. Soc. 99 (1977) 8127-8134; DOI: 10.1021/ja00467a001.10.1021/ja00467a001Search in Google Scholar

M. J. S. E. Dewar, G. Zoebisch, E. F. Healy and J. J. P. Stewart, AM1: a new general purpose quantum mechanical molecular model, J. Am. Chem. Soc. 107 (1985) 3902-3909; DOI: 10.1021/ja00299a024.10.1021/ja00299a024Search in Google Scholar

N. C. Cohen, Guidebook on Molecular Modeling, in Drug Design, Academic Press, San Diego 1996, p. 361.Search in Google Scholar

http://www.moldiscovery.com/soft_pentacle.phpSearch in Google Scholar

C. A. Boateng, S. V. K. Eyunni, X, Y. Zhu, J. R. Etukala, B. A. Bricker, M. K. Ashfaq, M. R. Jacob, S. I. Khan, L. A. Walker and S. Y. Ablordeppey, Synthesis and evaluation against opportunistic fungal pathogens, Bioorg. Med. Chem. 19 (2011) 458-470; DOI: 10.1016/j.bmc.2010.11.008.10.1016/j.bmc.2010.11.008301441921134759Search in Google Scholar