<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>A series of 1-(2-methyl-4-nitro-imidazol-1-yl)-3-arylaminopropan-2-ones (<bold>2a-e</bold>), 2-methyl-5-nitro-1-{2-[arylmethoxy] ethyl}-1<italic>H</italic>-imidazoles (<bold>5a-d</bold>), and <italic>N</italic>-(3-hydroxyphenyl)-2-(substituted imidazol-1-yl)alkanamides (<bold>8a-e</bold>) were synthesized with the aim to develop novel imidazole analogs with broad-spectrum chemotherapeutic properties. Title compounds were evaluated for their anti-HIV and antibacterial activities.</p></abstract>

A series of 1-(2-methyl-4-nitro-imidazol-1-yl)-3-arylaminopropan-2-ones (2a-e), 2-methyl-5-nitro-1-{2-[arylmethoxy] ethyl}-1H-imidazoles (5a-d), and N-(3-hydroxyphenyl)-2-(substituted imidazol-1-yl)alkanamides (8a-e) were synthesized with the aim to develop novel imidazole analogs with broad-spectrum chemotherapeutic properties. Title compounds were evaluated for their anti-HIV and antibacterial activities.

Synthesis, antibacterial and potential anti-HIV activity of some novel imidazole analogs

Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra Ranchi-835215, Jharkhand, India

Department of Applied Chemistry, Birla Institute of Technology, Mesra Ranchi-835215, Jharkhand, India

Acta Pharmaceutica

A series of 1-(2-methyl-4-nitro-imidazol-1-yl)-3-arylaminopropan-2-ones (2a-e), 2-methyl-5-nitro-1-{2-[arylmethoxy] ethyl}-1H-imidazoles (5a-d), and...

Synthesis, antibacterial and potential anti-HIV activity of some novel imidazole analogs

Data publikacji: 17 cze 2011

Zakres stron: 187 - 201

DOI: https://doi.org/10.2478/v10007-011-0018-2

Słowa kluczowe
imidazol, reverzna transkriptaza, nenukleozidna reverzna transkriptaza, anti-HIV, antibakterijski

This content is open access.

Synthesis, antibacterial and potential anti-HIV activity of some novel imidazole analogs

Data publikacji: 17 cze 2011

Zakres stron: 187 - 201

DOI: https://doi.org/10.2478/v10007-011-0018-2

Słowa kluczoweimidazol, reverzna transkriptaza, nenukleozidna reverzna transkriptaza, anti-HIV, antibakterijski

This content is open access.

Słowa kluczowe
imidazol, reverzna transkriptaza, nenukleozidna reverzna transkriptaza, anti-HIV, antibakterijski