Changes In Liver and Brain Cytochrome P450 after Multiple Cocaine Administration, Alone and in Combination with Nifedipine

Filip M, Frankowska M, Zaniewska M, Golda A, Przegalinski E. The serotonergic system and its role in cocaine addiction. Pharmacol Rep 2005;57:685-700.Search in Google Scholar

Sun L, Lau CE. Simultaneous pharmacokinetic modeling of cocaine and its metabolites, norcocaine and benzoylecgonine, after intravenous and oral administration in rats. Drug Metab Dispos 2001;29:1183-9.Search in Google Scholar

Arinc E, Bozcaarmutlu A. Catalyzation of cocaine N-demethylation by cytochromes P4502B, P4503A, and P4502D in fish liver. J Biochem Mol Toxicol 2003;17:169-76.10.1002/jbt.10075Search in Google Scholar

Liu XQ, Ren YL, Qian ZY, Wang GJ. Enzyme kinetics and inhibition of nimodipine metabolism in human liver microsomes. Acta Pharmacol Sin 2000;21:690-4.Search in Google Scholar

Vetulani J. Calcium and voltage-dependent calcium channels. Kismos 1997;46:491-505.Search in Google Scholar

etulani J. Drug addiction. Part III. Pharmacotherapy of addiction. Pol J Pharmacol 2001;53:415-35.Search in Google Scholar

Vitcheva V, Mitcheva M. Effects of Nifedipine on behavioral and biochemical parameters in rats after multiple morphine administration. Methods Find Exp Clin Pharmacol 2004;26:631-4.10.1358/mf.2004.26.8.863729Search in Google Scholar

Council of Europe. European Convention for the Protection of Vertebrate Animals used for Experimental and other Scientific Purposes. CETS No. 123, 1991. [displayed 30 May 2007] Available at http://conventions.coe.int/Treaty/Commun/QueVoulezVous.asp?NT=123&CM=1&CL=ENGSearch in Google Scholar

Antkiewicz-Michaluk L, Romanska I, Vetulani J. Ca²⁺ channel blockade prevents lysergic acid diethylamide-induced changes in dopamine and serotonin metabolism. Eur J Pharmacol 1997;332:9-14.10.1016/S0014-2999(97)01025-XSearch in Google Scholar

Itzhak Y, Ali SF, Martin JL, Black MD, Huang PL. Resistance of neuronal nitric oxide synthase-deficient mice to cocaine-induced locomotor sensitization. Psychopharmacol 1998;140:378-86.10.1007/s002130050779Search in Google Scholar

Bhagwat SV, Boyd MR, Ravindranath V. Rat brain cytochrome P 450. Reassessment of monooxygenase activities and cytochrome P450 levels. Drug Metab Disps 1995;23:651-4.Search in Google Scholar

Guengerich FP. Microsomal enzymes involved in toxicology. Analysis and separation. In: Heis AW, editor. Principals and Methods of Toxicology. New York (NY): Raven Press; 1987. p. 609-634.Search in Google Scholar

Omura T, Sato R. The carbon-monoxide-binding pigment of liver microsomes. J Biol Chem 1964;239:2370-85.10.1016/S0021-9258(20)82244-3Search in Google Scholar

Lowry OH. Protein measurement with the Folin phenol reagent. J Biol Chem 1951;193:265-75.10.1016/S0021-9258(19)52451-6Search in Google Scholar

Antkiewicz-Michaluk L, Michaluk J, Romanska I, Vetulani J. Reduction of morphine dependence and potenciation of analgesia by co-administration of nifedipin. Biopharmacol 1993;111:457-67.Search in Google Scholar

Watson WP, Little JJ. Effects of dihydropiridines on the components of the ethanol withdrawal syndrome: possible evidence for involvement of potassium, as well as calcium? Alcohol Clin Exp Res 1997;21:409-16.10.1111/j.1530-0277.1997.tb03784.xSearch in Google Scholar

Haward LA, Sellers EM, Tyndale RF. The role of pharmacogenetically - variable cytochrome P450 in drug abuse and dependence. Pharmacogenomics 2002;3:185-99.10.1517/14622416.3.2.185Search in Google Scholar

Koleva MR, Stoychev TS. Effect of nifedipine, verapamil and diltiazem on the enzyme-inducing activity of phenobarbital and beta-naphthoflavone. Gen Pharmacol 1995;26:225-8.10.1016/0306-3623(94)E0044-MSearch in Google Scholar

Kastelova A, Koleva M, Staneva-Stoytcheva D. Changes in rat liver monooxygenase activities after administration of atenolol, nifedipine and diltiazem alone and in combination. Methods Find Exp Clin Pharmacol. 2000;22:627-31.10.1358/mf.2000.22.8.80227411256234Search in Google Scholar

Shuster L, Garhart C, Powers J, Grunfeld Y, Kanel G. Hepatotoxicity of cocaine. NIDA Res Monogr 1988;88:250-75.Search in Google Scholar

Powers JF, Shuster L. Subacute cocaine treatment changes expression of mouse liver cytochrome P450 isoforms. Pharmacology 1999;58:87-100.10.1159/000028271Search in Google Scholar

Pasanen M, Pellinen P, Stenback F, Juvonen RO, Raunio H, Pelkonen O. The role of CYP enzymes in cocaineinduced liver damage. Arch Toxicol 1995;69:287-90.10.1007/s002040050172Search in Google Scholar

Nabeshima T, Fontenit J, Ho IK. Effect of chronic administration of phenobarbital or morphine on the brain micrisomal cytochrome P450 system. Biochem Pharmacol 1981;30:1142-5.10.1016/0006-2952(81)90456-1Search in Google Scholar