<abstract xmlns="http://www.w3.org/1999/xhtml"><p> When detection times for psychoactive drugs in oral fluid are reported, they are most often based on therapeutic doses administered in clinical studies. Repeated ingestions of high doses, as seen after drug abuse, are however likely to cause positive samples for extended time periods. Findings of drugs of abuse in oral fluid might lead to negative sanctions, and the knowledge of detection times of these drugs are important to ensure correct interpretation. The aim of this study was to investigate the detection times of opioids in oral fluid. 25 patients with a history of heavy drug abuse admitted to a detoxification ward were included. Oral fluid and urine were collected daily and, if the patient gave consent, a blood sample was drawn during the first five days after admission. Morphine, codeine and/or 6-monoacetyl morphine (6-MAM) were found in oral fluid and/or urine from 20 patients. The maximum detection times in oral fluid for codeine, morphine and 6-MAM were 1, 3 and 8 days, respectively. Positive oral fluid samples were interspersed with negative samples, mainly for concentrations around cut off. Elimination curves for methadone in oral fluid were found for two subjects, and the detection times were 5 and 8 days. Oral fluid is likely to become a good method for detection of drug abuse in the future</p></abstract>

When detection times for psychoactive drugs in oral fluid are reported, they are most often based on therapeutic doses administered in clinical studies. Repeated ingestions of high doses, as seen after drug abuse, are however likely to cause positive samples for extended time periods. Findings of drugs of abuse in oral fluid might lead to negative sanctions, and the knowledge of detection times of these drugs are important to ensure correct interpretation. The aim of this study was to investigate the detection times of opioids in oral fluid. 25 patients with a history of heavy drug abuse admitted to a detoxification ward were included. Oral fluid and urine were collected daily and, if the patient gave consent, a blood sample was drawn during the first five days after admission. Morphine, codeine and/or 6-monoacetyl morphine (6-MAM) were found in oral fluid and/or urine from 20 patients. The maximum detection times in oral fluid for codeine, morphine and 6-MAM were 1, 3 and 8 days, respectively. Positive oral fluid samples were interspersed with negative samples, mainly for concentrations around cut off. Elimination curves for methadone in oral fluid were found for two subjects, and the detection times were 5 and 8 days. Oral fluid is likely to become a good method for detection of drug abuse in the future

Very long Detection Times after High and repeated intake of Heroin and Methadone, measured in Oral Fluid

Norwegian Institute of Public Health, Division of Forensic Medicine and Drug Abuse Research, PO 4404, Nydalen, N-0403 Oslo, Norway

Emergency Department for Addictive Disorders, Oslo University Hospital, HF, Aker, PO 4959 Nydalen, N-0424 Oslo, Norway

Scandinavian Journal of Forensic Science

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

When detection times for psychoactive drugs in oral fluid are reported, they are most often based on therapeutic doses administered in clinical studies....

Very long Detection Times after High and repeated intake of Heroin and Methadone, measured in Oral Fluid

Data publikacji: 03 mar 2015

Zakres stron: 34 - 41

DOI: https://doi.org/10.2478/sjfs-2014-0004

Słowa kluczowe
Oral fluid, opioid, detection time, heroin, methadone

© Danish Society of Forensic Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Very long Detection Times after High and repeated intake of Heroin and Methadone, measured in Oral Fluid

Data publikacji: 03 mar 2015

Zakres stron: 34 - 41

DOI: https://doi.org/10.2478/sjfs-2014-0004

Słowa kluczoweOral fluid, opioid, detection time, heroin, methadone

© Danish Society of Forensic Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Słowa kluczowe
Oral fluid, opioid, detection time, heroin, methadone