Antitumor Activity of Palladium(II) Complexes on DU-145 Cell Line in Vitro

1. Jiang DM, Gupta S, Kitchlu A, Meraz-Munoz A, North SA, Alimohamed NS, Blais N, Sridhar SS. Defining cisplatin eligibility in patients with muscle-invasive bladder cancer. Nat Rev Urol. 2021;18(2):104-14.10.1038/s41585-020-00404-633432181 Search in Google Scholar

2. Hamano H, Ikeda Y, Goda M, Fukushima K, Kishi S, Chuma M, Yamashita M, Niimura T, Takechi K, Imanishi M, Zamami Y, Horinouchi Y, Izawa-Ishizawa Y, Miyamoto L, Ishizawa K, Fujino H, Tamaki T, Aihara KI, Tsuchiya K. Diphenhydramine may be a preventive medicine against cisplatin-induced kidney toxicity. Kidney Int. 2021;99(4):885-99.10.1016/j.kint.2020.10.04133307103 Search in Google Scholar

3. Assi S, Barling M, Al-Hamid A, Cheema E. Exploring the adverse effects of chemotherapeutic agents used in the treatment of cervical and ovarian cancer from the patients’ perspective: a content analysis of the online discussion forums. Eur J Hosp Pharm. 2021;28(Suppl 2):e35-e40.10.1136/ejhpharm-2019-002162864043032349988 Search in Google Scholar

4. Abadi AJ, Mirzaei S, Mahabady MK, Hashemi F, Zabolian A, Hashemi F, Raee P, Aghamiri S, Ashrafizadeh M, Aref AR, Hamblin MR, Hushmandi K, Zarrabi A, Sethi G. Curcumin and its derivatives in cancer therapy: Potentiating antitumor activity of cisplatin and reducing side effects. Phytother Res. 2021. doi: 10.1002/ptr.7305.10.1002/ptr.730534697839 Search in Google Scholar

5. Rottenberg S, Disler C, Perego P. The rediscovery of platinum-based cancer therapy. Nat Rev Cancer. 2021; 21(1):37-50.10.1038/s41568-020-00308-y33128031 Search in Google Scholar

6. Luo Y, Fu Y, Huang Z, Li M. Transition metals and metal complexes in autophagy and diseases. J Cell Physiol. 2021;236(10):7144-58.10.1002/jcp.3035933694161 Search in Google Scholar

7. Gill MR, Vallis KA. Transition metal compounds as cancer radiosensitizers. Chem Soc Rev. 2019; 21;48(2):540-57.10.1039/C8CS00641E Search in Google Scholar

8. Golbaghi G, Castonguay A. Rationally Designed Ruthenium Complexes for Breast Cancer Therapy. Molecules. 2020; 25(2):265.10.3390/molecules25020265702430131936496 Search in Google Scholar

9. Hussain A, AlAjmi MF, Rehman MT, Amir S, Husain FM, Alsalme A, Siddiqui MA, AlKhedhairy AA, Khan RA. Copper(II) complexes as potential anticancer and Nonsteroidal anti-inflammatory agents: In vitro and in vivo studies. Sci Rep. 2019;9(1):5237.10.1038/s41598-019-41063-x643719430918270 Search in Google Scholar

10. Zhang JX, Pan M, Su CY. Synthesis, photophysical properties and in vitro evaluation of a chlorambucil conjugated ruthenium(ii) complex for combined chemophotodynamic therapy against HeLa cells. J Mater Chem B. 2017;5(24):4623-32.10.1039/C7TB00702G Search in Google Scholar

11. Čanović P, Simović AR, Radisavljević S, Bratsos I, Demitri N, Mitrović M, Zelen I, Bugarčić ŽD. Impact of aromaticity on anticancer activity of polypyridyl ruthenium(II) complexes: synthesis, structure, DNA/protein binding, lipophilicity and anticancer activity. J Biol Inorg Chem. 2017;22(7):1007-28.10.1007/s00775-017-1479-728695374 Search in Google Scholar

12. Petrovic M, Popovic S, Baskic D, Todorovic M, Djurdjevic P, Ristic-Fira A, Keta O, Petkovic V, Koricanac L, Stojkovic D, Jevtic V, Trifunovic S, Todorovic D. The Effects of Newly Synthesized Platinum(IV) Complexes on Cytotoxicity and Radiosensitization of Human Tumour Cells In Vitro. Anticancer Res. 2020;40(9):5001-13.10.21873/anticanres.1450332878788 Search in Google Scholar

13. Liu G, Pei F, Yang F, Li L, Amin AD, Liu S, Buchan JR, Cho WC. Role of Autophagy and Apoptosis in Non- Small-Cell Lung Cancer. Int J Mol Sci. 2017;18(2):367.10.3390/ijms18020367534390228208579 Search in Google Scholar

14. Soofiyani SR, Hejazi MS, Baradaran B. The role of CIP2A in cancer: A review and update. Biomed Pharmacother. 2017;96:626-33.10.1016/j.biopha.2017.08.14629035828 Search in Google Scholar

15. Kashyap D, Garg VK, Goel N. Intrinsic and extrinsic pathways of apoptosis: Role in cancer development and prognosis. Adv Protein Chem Struct Biol. 2021;125:73-120.10.1016/bs.apcsb.2021.01.00333931145 Search in Google Scholar

16. Kędzierska H, Piekiełko-Witkowska A. Splicing factors of SR and hnRNP families as regulators of apoptosis in cancer. Cancer Lett. 2017;396:53-65.10.1016/j.canlet.2017.03.01328315432 Search in Google Scholar

17. Amidfar M, Karami Z, Kheirabadi GR, Afshar H, Esmaeili A. Expression of Bcl-2 and Bax genes in peripheral blood lymphocytes of depressed and nondepressed individuals. J Res Med Sci. 2019;24:41.10.4103/jrms.JRMS_811_17654077031160908 Search in Google Scholar

18. Bjelogrlić SK, Todorović TR, Kojić M, Senćanski M, Nikolić M, Višnjevac A, Araškov J, Miljković M, Muller CD, Filipović NR. Pd(II) complexes with N-heteroaromatic hydrazone ligands: Anticancer activity, in silico and experimental target identification. J Inorg Biochem. 2019; 199:110758.10.1016/j.jinorgbio.2019.11075831299379 Search in Google Scholar

19. Zafar MN, Butt AM, Chaudhry GE, Perveen F, Nazar MF, Masood S, Dalebrook AF, Mughal EU, Sumrra SH, Sung YY, Muhammad TST, Wright LJ. Pd(II) complexes with chelating N-(1-alkylpyridin-4(1H)-ylidene) amide (PYA) ligands: Synthesis, characterization and evaluation of anticancer activity. J Inorg Biochem. 2021;224:111590.10.1016/j.jinorgbio.2021.11159034507110 Search in Google Scholar

20. Reig M, Bosque R, Font-Bardía M, Calvis C, Messeguer R, Baldomà L, Badía J, Velasco D, López C. A study of the properties, reactivity, and anticancer activity of novel N-methylated-3-thiazolyl or 3-thienyl carbazoles and their Pd(II) and Pt(II) complexes. J Inorg Biochem. 2018;184:134-45.10.1016/j.jinorgbio.2018.03.00829751214 Search in Google Scholar

21. Oliveira CG, Romero-Canelón I, Coverdale JPC, Maia PIS, Clarkson GJ, Deflon VM, Sadler PJ. Novel tetranuclear Pd^II and Pt^II anticancer complexes derived from pyrene thiosemicarbazones. Dalton Trans. 2020;49(28):9595-9604.10.1039/D0DT01133A Search in Google Scholar

22. Kacar O, Cevatemre B, Hatipoglu I, Arda N, Ulukaya E, Yilmaz VT, Acilan C. The role of cell cycle progression for the apoptosis of cancer cells induced by palladium(II)-saccharinate complexes of terpyridine. Bioorg Med Chem. 2017;25(6):1770-77.10.1016/j.bmc.2017.01.03328196706 Search in Google Scholar

23. Plumb JA. Cell sensitivity assays: the MTT assay. Methods Mol Med. 1999;28:25-30.10.1385/1-59259-687-8:25 Search in Google Scholar

24. Ndagi U, Mhlongo N, Soliman ME. Metal complexes in cancer therapy - an update from drug design perspective. Drug Des Devel Ther. 2017;11:599-616.10.2147/DDDT.S119488534441228424538 Search in Google Scholar

25. Frezza M, Hindo S, Chen D, et al. Novel metals and metal complexes as platforms for cancer therapy. Curr Pharm Des. 2010;16(16):1813-25.10.2174/138161210791209009375928720337575 Search in Google Scholar

26. Mjos KD, Orvig C. Metallodrugs in medicinal inorganic chemistry. Chem Rev. 2014;114(8):4540-63.10.1021/cr400460s24456146 Search in Google Scholar

27. Hernández W, Paz J, Carrasco F, et al. Synthesis and Characterization of New Palladium(II) Thiosemicarbazone Complexes and Their Cytotoxic Activity against Various Human Tumor Cell Lines. Bioinorg Chem Appl. 2013;2013:524701.10.1155/2013/524701387434124391528 Search in Google Scholar

28. Carreira M, Calvo-Sanjuán R, Sanaú M, Marzo I, Contel M. Organometallic Palladium Complexes with a Water- Soluble Iminophosphorane Ligand as Potential Anticancer Agents. Organometallics. 2012;31(16):5772-81.10.1021/om3006239346659423066172 Search in Google Scholar

29. Plutín AM, Mocelo R, Alvarez A, Ramos R, Castellano EE, Cominetti MR, Graminha AE, Ferreira AG, Batista AA. On the cytotoxic activity of Pd(II) complexes of N,N-disubstituted-N’-acyl thioureas. J Inorg Biochem. 2014;134:76-82.10.1016/j.jinorgbio.2014.01.02224561278 Search in Google Scholar

30. Jan R, Chaudhry GE. Understanding Apoptosis and Apoptotic Pathways Targeted Cancer Therapeutics. Adv Pharm Bull. 2019;9(2):205-18.10.15171/apb.2019.024666411231380246 Search in Google Scholar

31. Laubach V, Kaufmann R, Bernd A, Kippenberger S, Zöller N. Extrinsic or Intrinsic Apoptosis by Curcumin and Light: Still a Mystery. Int J Mol Sci. 2019;20(4):905.10.3390/ijms20040905641284930791477 Search in Google Scholar

32. Kiraz Y, Adan A, Kartal Yandim M, Baran Y. Major apoptotic mechanisms and genes involved in apoptosis. Tumour Biol. 2016;37(7):8471-86.10.1007/s13277-016-5035-927059734 Search in Google Scholar

33. Goelz N, Eekels JJM, Pantic M, Kamber CT, Speer O, Franzoso FD, Schmugge M. Platelets express adaptor proteins of the extrinsic apoptosis pathway and can activate caspase-8. PLoS One. 2021;16(1):e0244848.10.1371/journal.pone.0244848779976833428668 Search in Google Scholar

34. Joksimović N, Janković N, Petronijević J, Baskić D, Popovic S, Todorović D, Zarić M, Klisurić O, Vraneš M, Tot A, Bugarčić Z. Synthesis, Anticancer Evaluation and Synergistic Effects with cisplatin of Novel Palladium Complexes: DNA, BSA Interactions and Molecular Docking Study. Med Chem. 2020;16(1):78-92.10.2174/157340641566619012809573230686264 Search in Google Scholar

35. Espino J, Fernández-Delgado E, Estirado S, de la Cruz-Martinez F, Villa-Carballar S, Viñuelas-Zahínos E, Luna-Giles F, Pariente JA. Synthesis and structure of a new thiazoline-based palladium(II) complex that promotes cytotoxicity and apoptosis of human promyelocytic leukemia HL-60 cells. Sci Rep. 2020;10(1):16745.10.1038/s41598-020-73488-0754217233028870 Search in Google Scholar

36. Keswani, T., Chowdhury, S., Mukherjee, S., & Bhattacharyya, A. Palladium(II) complex induces apoptosis through ROS-mediated mitochondrial pathway in human lung adenocarcinoma cell line (A549). Current Science. 2014;107(10);1711–19. Search in Google Scholar

37. Hadizadeh S, Najafzadeh N, Mazani M, Amani M, Mansouri-Torshizi H, Niapour A. Cytotoxic Effects of Newly Synthesized Palladium(II) Complexes of Diethyldithiocarbamate on Gastrointestinal Cancer Cell Lines. Biochem Res Int. 2014;2014:813457.10.1155/2014/813457413141225147738 Search in Google Scholar