<abstract xmlns="http://www.w3.org/1999/xhtml">The interactions of metal complexes with important biomolecules such as deoxyribonucleic acid (DNA) or bovine serum albumin (BSA) are responsible for their antitumor activity due to different modes of interaction with DNA and their transport through the blood system to cells and tissues via serum albumin. Therefore, the dinuclear palladium(II) complexes, [{Pd(en)Cl}2(μ-1,5- nphe)](NO3)2 (<bold>Pd1</bold>) and [{Pd(1,3-pd)Cl}2(μ-1,5-nphe)](NO3)2 (<bold>Pd2</bold>) (en is ethylenediamine, 1,3-pd is 1,3-propylenediamine and 1,5-nphe is the bridging 1,5-naphthyridine ligand) were synthesized and characterized by different spectroscopic methods. The UV-Vis and fluorescence emission spectroscopy were applied for evaluation of binding modes of <bold>Pd1</bold> and <bold>Pd2</bold> complexes to DNA as well as their interaction with BSA. The emission spectra indicate that the investigated <bold>Pd1</bold> and <bold>Pd2</bold> complexes can displace the ethidium bromide intercalator from DNA/EtBr molecules and act as intercalators showing strong interactions with DNA. The fluorescence intensity showes that <bold>Pd1</bold> and <bold>Pd2</bold> complexes can bind to BSA and then be transported to the cell.</abstract>

The interactions of metal complexes with important biomolecules such as deoxyribonucleic acid (DNA) or bovine serum albumin (BSA) are responsible for their antitumor activity due to different modes of interaction with DNA and their transport through the blood system to cells and tissues via serum albumin. Therefore, the dinuclear palladium(II) complexes, [{Pd(en)Cl}2(μ-1,5- nphe)](NO3)2 (Pd1) and [{Pd(1,3-pd)Cl}2(μ-1,5-nphe)](NO3)2 (Pd2) (en is ethylenediamine, 1,3-pd is 1,3-propylenediamine and 1,5-nphe is the bridging 1,5-naphthyridine ligand) were synthesized and characterized by different spectroscopic methods. The UV-Vis and fluorescence emission spectroscopy were applied for evaluation of binding modes of Pd1 and Pd2 complexes to DNA as well as their interaction with BSA. The emission spectra indicate that the investigated Pd1 and Pd2 complexes can displace the ethidium bromide intercalator from DNA/EtBr molecules and act as intercalators showing strong interactions with DNA. The fluorescence intensity showes that Pd1 and Pd2 complexes can bind to BSA and then be transported to the cell.

DNA-and BSA-Binding Studies of Dinuclear Palladium(II) Complexes with 1,5-Naphtiridine Bridging Ligands

University of Kragujevac, Faculty of Science

Faculty of Medical Sciences, Department of Internal Medicine

University Clinical Center, Clinic for Pulmonology

Faculty of Medical Sciences, Department of Pharmacy

Experimental and Applied Biomedical Research (EABR)

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

The interactions of metal complexes with important biomolecules such as deoxyribonucleic acid (DNA) or bovine serum albumin (BSA) are responsible for their...

DNA-and BSA-Binding Studies of Dinuclear Palladium(II) Complexes with 1,5-Naphtiridine Bridging Ligands

Data publikacji: 22 cze 2021

Zakres stron: -

Otrzymano: 22 sty 2021

Przyjęty: 24 lut 2021

DOI: https://doi.org/10.2478/sjecr-2021-0030

Słowa kluczowe
Dinuclear palladium(II) complexes, 1,5-naphthyridine, DNA, bovine serum albumin (BSA)

© 2021 Snežana Rajković et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

DNA-and BSA-Binding Studies of Dinuclear Palladium(II) Complexes with 1,5-Naphtiridine Bridging Ligands

Data publikacji: 22 cze 2021

Zakres stron: -

Otrzymano: 22 sty 2021

Przyjęty: 24 lut 2021

DOI: https://doi.org/10.2478/sjecr-2021-0030

Słowa kluczoweDinuclear palladium(II) complexes, 1,5-naphthyridine, DNA, bovine serum albumin (BSA)

© 2021 Snežana Rajković et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Słowa kluczowe
Dinuclear palladium(II) complexes, 1,5-naphthyridine, DNA, bovine serum albumin (BSA)