<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Mesenchymal stem cells (MSCs) are multipotent stem cells with numerous features potentially useful in various pathologies. It has been shown that MSCs have regenerative potential due to modulation of immune system response, inflammation diminishing, trans differentiation into various types of cells, proangiogenetic and anti fibrotic influence. Besides all of these traits, MSCs posses anti viral capacity and have been further employed in clinical trails since last year. Here, we revised immunomodulatory, biological and antiviral traits of MSCs, but also pathogenesis of Covid-19 and it’s impact on immune system. Conspicuously, there is a growing number of studies examining effect of MSCs in patients suffering from Covid-19 pneumonia and ARDS. Since MSCs are in theory capable of healing lung injury and inflammation, here we discuss hypothesis, pros and cons of MSCs treatment in Covid-19 patients. Finally, we debate if MSCs based therapy can be promising tool for Covid-19 lung pathologies.</p>
</abstract>

Mesenchymal stem cells (MSCs) are multipotent stem cells with numerous features potentially useful in various pathologies. It has been shown that MSCs have regenerative potential due to modulation of immune system response, inflammation diminishing, trans differentiation into various types of cells, proangiogenetic and anti fibrotic influence. Besides all of these traits, MSCs posses anti viral capacity and have been further employed in clinical trails since last year. Here, we revised immunomodulatory, biological and antiviral traits of MSCs, but also pathogenesis of Covid-19 and it’s impact on immune system. Conspicuously, there is a growing number of studies examining effect of MSCs in patients suffering from Covid-19 pneumonia and ARDS. Since MSCs are in theory capable of healing lung injury and inflammation, here we discuss hypothesis, pros and cons of MSCs treatment in Covid-19 patients. Finally, we debate if MSCs based therapy can be promising tool for Covid-19 lung pathologies.

Mesenchymal Stem Cells Versus Covid-19. Can They Win the Battle?

University of Kragujevac, Faculty of Medical Sciences

Experimental and Applied Biomedical Research (EABR)

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Mesenchymal Stem Cells Versus Covid-19. Can They Win the Battle?"}

Mesenchymal stem cells (MSCs) are multipotent stem cells with numerous features potentially useful in various pathologies. It has been shown that MSCs have...

Mesenchymal Stem Cells Versus Covid-19. Can They Win the Battle?

Data publikacji: 09 gru 2021

Zakres stron: -

Otrzymano: 23 mar 2021

Przyjęty: 03 kwi 2021

DOI: https://doi.org/10.2478/sjecr-2021-0024

Słowa kluczowe
mesenchymal stem cells, inflammation, covid-19, pneumonia, ARDS

© 2021 Amra Ramovic Hamzagic et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Mesenchymal Stem Cells Versus Covid-19. Can They Win the Battle?

Data publikacji: 09 gru 2021

Zakres stron: -

Otrzymano: 23 mar 2021

Przyjęty: 03 kwi 2021

DOI: https://doi.org/10.2478/sjecr-2021-0024

Słowa kluczowemesenchymal stem cells, inflammation, covid-19, pneumonia, ARDS

© 2021 Amra Ramovic Hamzagic et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Słowa kluczowe
mesenchymal stem cells, inflammation, covid-19, pneumonia, ARDS